Reynolds de Sousa T, Ribeiro M, Novais F. Assessment of Innovative Pharmacological Targets in Schizophrenia. Curr Treat Options Psychiatry. 2024;11(3):203–17.
Szkultecka-Dębek M, Walczak J, Augustyńska J, Miernik K, Stelmachowski J, Pieniążek I, Obrzut G, Pogroszewska A, Paulić G, Damir M, Antolić S. Epidemiology and treatment guidelines of negative symptoms in schizo-phrenia in central and eastern Europe: a literature review. Clin Pract Epidemiol mental health: CP EMH. 2015;11:158.
Article PubMed PubMed Central Google Scholar
Jarab A, Al-Qerem W, Khdour A, Awadallah H, Mimi Y, Khdour M. Novel pharmaceutical treatment approaches for schizophrenia: a systematic literature review. Eur J Clin Pharmacol 2025;14:1–7.
Hall J. Schizophrenia–new treatments soon. Br J Psychiatry. 2025;226(3):127–8.
Anwar A, Mustafa AM, Abdou K, Rabie A, El-Shiekh M, El-Dessouki RA. A comprehensive review on schizophrenia: epidemiology, pathogenesis, diagnosis, conventional treatments, and proposed natural compounds used for management. Naunyn-Schmiedeberg’s Archives of Pharmacology. Jun. 2025;13:1–25.
Yang H, Sun W, Yang M, Li J, Zhang J, Zhang X. Variations to plasma H2O2 levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology. Schizophrenia. 2024;10(1):45.
Article PubMed PubMed Central Google Scholar
Zhang K, Zou L, Cai Y. Progress in the study of oxidative stress damage in patients with schizophrenia: challenges and opportunities. Front Psychiatry. 2025;16:1505397.
Article PubMed PubMed Central Google Scholar
Herniman SE, Wood SJ, Khandaker G, Dazzan P, Pariante CM, Barnes NM, Krynicki CR, Nikkheslat N, Vincent RC, Roberts A, Giordano A. Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial. Translational psychiatry. 2023;13(1):297.
Article CAS PubMed PubMed Central Google Scholar
Lv H, Guo M, Guo C, He K. The interrelationships between cytokines and schizophrenia: a systematic review. Int J Mol Sci. 2024;25(15):8477.
Article CAS PubMed PubMed Central Google Scholar
Dash UC, Bhol NK, Swain SK, Samal RR, Nayak PK, Raina V, et al. Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications. Acta Pharm Sin B. 2025;15(1):15–34.
Article CAS PubMed Google Scholar
Morén C, Treder N, Martínez-Pinteño A, Rodríguez N, Arbelo N, Madero S, Gómez M, Mas S, Gassó P, Parellada E. Systematic review of the therapeutic role of apoptotic inhibitors in neurodegeneration and their potential use in schizophrenia. Antioxidants. 2022;11(11):2275.
Article PubMed PubMed Central Google Scholar
Saint-Georges Z, MacDonald J, Al-Khalili R, Hamati R, Solmi M, Keshavan MS, Tuominen L, Guimond S. Cholinergic system in schizophrenia: A systematic review and meta-analysis. Mol Psychiatry. 2025;20:1–5.
Metz CN, Brines M, Pavlov VA. Bridging cholinergic signalling and inflammation in schizophrenia. Schizophrenia. 2024;10(1):51.
Article PubMed PubMed Central Google Scholar
Shaju A, Mishra A, Mohapatra D, Srinivasan A, Maiti R. Efficacy and safety of cholinergic modulators in patients with schizophrenia: meta-analysis of randomised controlled trials. Br J Psychiatry. 2025;2:1–1.
Benvenutti R, Gallas-Lopes M, Marcon M, Reschke CR, Herrmann AP, Piato A. Glutamate NMDA receptor antagonists with relevance to schizophrenia: a review of zebrafish behavioral studies. Curr Neuropharmacol. 2022;20(3):494–509.
Article CAS PubMed PubMed Central Google Scholar
Moghaddam AH, Estalkhi FM, Jelodar SK, Hasan TA, Farhadi-Pahnedari S, Karimian M. Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: focusing on oxidative stress status. IBRO Neurosci Rep. 2024;16:182–9.
Phensy A, Driskill C, Lindquist K, Guo L, Jeevakumar V, Fowler B, Du H, Kroener S. Antioxidant treatment in male mice prevents mitochondrial and synaptic changes in an NMDA receptor dysfunction model of schizophrenia. ENeuro. 2017;4(4).
Uruaka CI, Ben-Azu B, Omeiza NA, Chidebe EO, Ajayi AM, Lemii CB, Nonju TI, Georgewill UO, Georgewill OA. Inhibition of oxidative stress, neuroinflammatory cytokines, and protein expressions contributes to the antipsychotic effects of geraniol in mice with ketamine-induced schizophrenia. J Neuroimmune Pharmacol. 2025;20(1):1–23.
Ishola IO, Ben-Azu B, Adebayo OA, Ajayi AM, Omorodion IL, Edje KE, et al. Prevention and reversal of ketamine-induced experimental psychosis in mice by the neuroactive flavonoid, hesperidin: the role of oxidative and cholinergic mechanisms. Brain Res Bull. 2021;177:239–51.
Article CAS PubMed Google Scholar
Saxena B. Eugenol as Neuro-Phytomedicine: Recent Trends Pertaining to the Treatment of Neurological Disorders. NeuroPhytomedicine. Jan. 2024;29:187–204.
Tripathy NS, Sahoo L, Paikray SK, Dilnawaz F. Eugenol: the phytocompound’s potential biological applications. BioNanoScience. 2024;14(4):4044–55.
Parween N, Jabeen A, Prasad B. Eugenol-a review of a versatile molecule with remarkable pharmacological properties. J Adv Sci Res. 2021;12(02):8–12.
Barboza JN, da Silva Maia Bezerra Filho C, Silva RO, Medeiros JV, de Sousa DP. An overview on the anti-inflammatory potential and antioxidant profile of eugenol. Oxid Med Cell Longev. 2018;2018(1):3957262.
Article PubMed PubMed Central Google Scholar
Kakkar A, Singh H, Anand A, Chopra H, Mishra AK. Neuroprotective Effects of Eugenol in Alzheimer’s Disease: Mitigating Oxidative Stress, Inflammation and Amyloid Plaques. Curr Pharm Design. 2025.
Irie Y. Effects of eugenol on the central nervous system: its possible application to treatment of Alzheimer’s disease, depression, and Parkinson’s disease. Curr Bioact Compd. 2006;2(1):57–66.
Sargsyan T, Simonyan HM, Stepanyan L, Tsaturyan A, Vicidomini C, Pastore R, Guerra G, Roviello GN. Neuroprotective Properties of Clove (Syzygium aromaticum): State of the Art and Future Pharmaceutical Applications for Alzheimer’s Disease. Biomolecules. 2025;15(3):452.
Article CAS PubMed PubMed Central Google Scholar
Vora U, Vyas VK, Wal P, Saxena B. Effects of eugenol on the behavioral and pathological progression in the MPTP-induced Parkinson’s disease mouse model. Drug Discov Ther. 2022;16(4):154–63.
Article CAS PubMed Google Scholar
Horka P, Langova V, Hubeny J, Vales K, Chrtkova I, Horacek J. Open field test for the assessment of anxiety-like behavior in Gnathonemus petersii fish. Front Behav Neurosci. 2024;17:1280608.
Article PubMed PubMed Central Google Scholar
Oyovwi MO, Ben-Azu B, Edesiri TP, Victor E, Rotu RA, Ozegbe QE, Nwangwa EK, Atuadu V, Adebayo OG. Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: the implications for neuroendopathobiological changes during chemotherapy. Biomed Pharmacother. 2021;142:112022.
Article CAS PubMed Google Scholar
Kim DG, Gonzales EL, Kim S, Kim Y, Adil KJ, Jeon SJ, et al. Social interaction test in home cage as a novel and ethological measure of social behavior in mice. Exp Neurobiol. 2019;28(2):247.
Article PubMed PubMed Central Google Scholar
Hassanzadeh-Taheri M, Ahmadi-Zohan A, Mohammadifard M, Hosseini M. Rosmarinic acid attenuates lipopolysaccharide-induced neuroinflammation and cognitive impairment in rats. J Chem Neuroanat. 2021;117(1):102008.
Article CAS PubMed Google Scholar
Onyekweli CC, Ben-Azu B, Nwangwa EK, Oyovwi OM. Potential effects of epigallocatechin-gallate against high-fat diet-induced memory decline andtesticular abnormalities in male wistar rats. J Appl Sci Environ Manage. 2024;28(10):3079–95.
Tesi EP, Ben-Azu B, Mega OO, Mordi J, Knowledge OO, Awele ED, Rotu RA, Emojevwe V, Adebayo OG, Eneni OA. Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways. J Food Biochem. 2022;46(4):e14071.
Article CAS PubMed Google Scholar
Oyovwi MO, Ben-Azu B, Falajiki FY, Onome OB, Rotu RA, Rotu RA, Oyeleke AA, Okwute GP, Moke EG. D-ribose-L-cysteine exhibits restorative neurobehavioral functions through modulation of neurochemical activities and inhibition oxido-inflammatory perturbations in rats exposed to polychlorinated biphenyl. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(2):931–45.
Article CAS PubMed Google Scholar
Oyovwi MO, Ugwuishi EW, Udi OA, Atere AD, Rotu AR, Odokuma EI, et al. Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1,/mTOR/Atg-7, and Cx-43/NOX-1 levels. European Journal of Medicinal Chemistry Reports. 2025;13(1):100243.
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