Romagnani P, Agarwal R, Chan JCN, Levin A, Kalyesubula R, Karam S, Nangaku M, Rodríguez-Iturbe B, Anders HJ. Chronic kidney disease. Nat Rev Dis Primers. 2025;11(1):8. https://doi.org/10.1038/s41572-024-00589-9.
Kung CW, Chou YH. Acute kidney disease: an overview of the epidemiology, pathophysiology, and management. Kidney Res Clin Pract. 2023;42(6):686–99. https://doi.org/10.23876/j.krcp.23.001.
Article PubMed PubMed Central Google Scholar
2019 GBD. Global Burden of Disease Study: CKD metrics. Lancet. 2020;395(10225):709–33. https://doi.org/10.1016/S0140-6736(20)30566-5.
2019 GBD. DALYs and mortality for CKD. Lancet. 2020;395(10225):709–33. https://doi.org/10.1016/S0140-6736(20)30566-5.
Qin K, Qing J, Wang Q, Li Y. Epidemiological shifts in chronic kidney disease: a 30-year global and regional assessment. BMC Public Health. 2024;24(1):3519. https://doi.org/10.1186/s12889-024-21065-9.
Article PubMed PubMed Central Google Scholar
Zhang H, Sun SC. NF-κB in inflammation and renal diseases. Cell Biosci. 2015;5:63. https://doi.org/10.1186/s13578-015-0056-4.
Article CAS PubMed PubMed Central Google Scholar
Rende U, Guller A, Goldys EM, Pollock C, Saad S. Diagnostic and prognostic biomarkers for tubulointerstitial fibrosis. J Physiol. 2023;601(14):2801–26. https://doi.org/10.1113/jp284289.
Article CAS PubMed Google Scholar
Wen Y, Zhang X, Wei L, Wu M, Cheng Y, Zheng H, Shen A, Fu C, Ali F, Long L, Lu Y. Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis. Front Pharmacol. 2023;14:1082281. https://doi.org/10.3389/fphar.2023.108228.
Article CAS PubMed PubMed Central Google Scholar
Kamel WA, Haghi M, Khosroshahi HT, Dehghan G. The association of RAGE gene polymorphisms with inflammatory and oxidative stress markers in diabetic kidney disease patients. Mol Biol Rep. 2025;52(1):759. https://doi.org/10.1007/s11033-025-10846-z.
Article CAS PubMed Google Scholar
Wang W, Hu Y, Ding N, Wei J, Li C. Role of SIRT1 in kidney diseases: A mechanistic overview. Int Urol Nephrol. 2024;56(2):215–28. https://doi.org/10.1007/s11255-024-04162-x.
Wang J, Zhong J, Yang HC, Fogo AB. Cross-talk from tubules to glomeruli. Toxicol Pathol. 2018;46(5):456–68. https://doi.org/10.1177/0192623318796784.
Wang YN, Wu X, Shan QY, Yang Q, Yu XY, Yang JH, Miao H, Cao G, Zhao YY. Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease. Acta Pharmacol Sin. 2025;46(11):2975–88. https://doi.org/10.1038/s41401-025-01476-z.
Article CAS PubMed PubMed Central Google Scholar
Zhao BR, Hu XR, Wang WD, Zhou Y. Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies. Acta Pharmacol Sin. 2025;46(6):1539–55. https://doi.org/10.1038/s41401-025-01476-z.
Article CAS PubMed PubMed Central Google Scholar
Jiang CH, Zhang SJ, Li P, Miao H, Zhao YY. Natural products targeting TGF-β/Smad signaling in renal fibrosis: Multiomics-based novel molecular mechanisms and therapeutic strategies. Phytomedicine. 2025;148:157496. https://doi.org/10.1016/j.phymed.2025.157496.
Article CAS PubMed Google Scholar
Zhao H, Zhao T, Li P. Gut microbiota-derived metabolites: a new perspective of traditional Chinese medicine against diabetic kidney disease. Integr Med Nephrol Androl. 2024;11(2):e23–00024. https://doi.org/10.1097/IMNA-D-23-00024.
Zhong X, Jia J, Tan R, Wang L. Hederagenin improves adriamycin-induced nephropathy by inhibiting the JAK/STAT signaling pathway. Integr Med Nephrol Androl. 2024;11(2):e22–00016. https://doi.org/10.1097/IMNA-D-22-00016.
Wang YN, Li XJ, Wang WF, Zou L, Miao H, Zhao YY. Geniposidic Acid Attenuates Chronic Tubulointerstitial Nephropathy Through Regulation of the NF-ƙB/Nrf2 Pathway Via Aryl Hydrocarbon Receptor Signaling. Phytother Res. 2024;38(11):5441–57. https://doi.org/10.1002/ptr.8324.
Article CAS PubMed Google Scholar
Wang Y, Bai M, Wang X, Peng Z, Cai C, Xi J, Yan C, Luo J, Li X. Gastrodin: a comprehensive pharmacological review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(6):3781–802. https://doi.org/10.1007/s00210-023-02920-9.
Article CAS PubMed Google Scholar
Shi Z, Zhang Y, Xiao Y, Shi Z, Wei X, Wang B, Yuan Y, Li P. The protective effects of gastrodin on neurological disorders: an update and future perspectives. Front Pharmacol. 2024;15:1494277. https://doi.org/10.3389/fphar.2024.1494277.
Article CAS PubMed PubMed Central Google Scholar
Huang L, Shao M, Zhu Y. Gastrodin inhibits high glucose-induced inflammation, oxidative stress and apoptosis in podocytes by activating the AMPK/Nrf2 signaling pathway. Exp Ther Med. 2022;23(2):168. https://doi.org/10.3892/etm.2021.11091.
Article CAS PubMed Google Scholar
Ding H, Wang WX, Liang QD, Tang CF, Xu TD, Miao ZA, Han BX, Kong LD. Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation. Int J Biol Sci. 2026;22(3):1162. https://doi.org/10.7150/ijbs.120307.
Article PubMed PubMed Central Google Scholar
Arab HH, Althobaiti MM, Alharthi AS, Almalki EO, Alsoubie SS, Qattan JM, Almalki SA, Ashour AM, Eid AH. Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway. Pharmaceuticals. 2024;17(12):1690. https://doi.org/10.3390/ph17121690.
Article CAS PubMed PubMed Central Google Scholar
Orji OU, Awoke NJ, Uti DE, Obasi OD, Aja PM, Nwamaka EN, Umoru GU, Ogbu PN, Udoudoh MP, Alum EU, Ogbu CO. The Therapeutic Role of Gastrodin in Combating Insulin Resistance, Inflammation, and Oxidative Stress Induced by Bisphenol-A. Nat Prod Commun. 2024;19(12). https://doi.org/10.1177/1934578X241310096.
Zuo HJ, Wang PX, Ren XQ, Shi HL, Shi JS, Guo T, Wan C, Li JJ. Gastrodin regulates PI3K/AKT-Sirt3 signaling pathway and proinflammatory mediators in activated microglia. Mol Neurobiol. 2024;61(5):2728–44. https://doi.org/10.1007/s12035-023-03743-8.
Article CAS PubMed Google Scholar
Jun L, Zhong-Liang W, Hui-Xian W. Pharmacokinetic Study of Gastrodin in Injection. Pharm J Chin People’s Lib Army. 2006;22:391–3.
Ju XH, Shi Y, Liu N, Guo DM, Cui X. Determination and pharmacokinetics of gastrodin in human plasma by HPLC coupled with photodiode array detector. J Chromatogr B. 2010;878(22):1982–6. https://doi.org/10.1016/j.jchromb.2010.05.034.
Jia Y, Li X, Xie H, Shen J, Luo J, Wang J, Wang KD, Liu Q, Kong L. Analysis and pharmacokinetics studies of gastrodin and p-hydroxybenzyl alcohol in dogs using ultra-fast liquid chromatography–tandem mass spectrometry method. J Pharm Biomed Anal. 2014;99:83–8. https://doi.org/10.1016/j.jpba.2014.07.004.
Article CAS PubMed Google Scholar
Wang Q, Chen G, Zeng S. Pharmacokinetics of Gastrodin in rat plasma and CSF after in and iv. Int J Pharm. 2007;341(1–2):20–5. https://doi.org/10.1016/j.ijpharm.2007.03.041.
Article CAS PubMed Google Scholar
Jiang L, Dai J, Huang Z, Du Q, Lin J, Wang Y. Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. J Chromatogr B. 2013;915:8–12. https://doi.org/10.1016/j.jchromb.2012.12.011.
Liu N, Zhang ZX, Ma JG, Zhang ZJ, Tian Y. Studies on pharmacokinetics and tissue distribution of gastrodin in rats. Chin J Pharm Anal. 2015;35(8):1369–76.
Nepal MR, Jeong KS, Kim GH, Cha DH, Kang MJ, Kim JS, Kim JH, Jeong TC. Role of intestinal microbiota in metabolism of gastrodin in vitro and in vivo. Metabolites. 2019;9(4):69. https://doi.org/10.3390/metabo9040069.
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