Priya V. WHO world malaria report 2024. Lancet Microbe. 2024;6(4):101073.

Google Scholar 

Roy S, Chancey R, Cantey P, Straily A, Trypanosomiasis, African. CDC Yellow Book. 2024. Available at: https://wwwnc.cdc.gov/travel/yellowbook/2024/infectious-diseases/trypanosomiasis-african.

World Health Organization. Leishmaniasis. 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/leishmaniasis.

Maloueki U, Mbomba ID, Ndimbo KSP. Screening phytochimique et activités antiplasmodiales comparées de quelques plantes consommées par les bonobos (Pan paniscus) de la station de Lui-Kotale, R.D. Congo. Ann Afr Med. 2015;6:64.

Google Scholar 

Dize D, Tali MBT, Ngansop CAN, Keumoe R, Madiesse Kemgne EA, Yamthe LRT, Tsouh Fokou PV, Pone Kamdem B, Hata K. Fekam Boyom F. Target-based 6–5 fused ring heterocyclic scaffolds display broad antiparasitic potency in vitro. Future Pharmacol. 2024;4(1):188–98. https://doi.org/10.3390/futurepharmacol4010013.

Article  Google Scholar 

Ortiz JE, Piñeiro M, Kaiser M, Mäser P, Bastida J, Feresin GE. Anti-trypanosomatid and antiplasmodial activities of alkaloids from Hippeastrum species. Chem Biodivers. 2025;22(8):e202500015. https://doi.org/10.1002/cbdv.202500015.

Article  CAS  PubMed  Google Scholar 

Boyom FF, Tsouh FVP, Tchokouaha YRL, Mfopa NA, Kemgne ME, Mbacham FW, Tsamo ET, Zollo APH, Gut J, Rosenthal PJ. Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol. 2011;134:717–24.

Article  PubMed  Google Scholar 

Mao EY, Page SW, Sleebs BE, Gancheva MR, Wilson DW. A review of natural products as a source of next-generation drugs against apicomplexan parasites. NPJ Antimicrob Resist. 2025;3(1):51. https://doi.org/10.1038/s44259-025-00119-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nureye D, Assefa S, Nedi T, Engidawork E. Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evid Based Complement Alternat Med. 2018;2018:9217835. https://doi.org/10.1155/2018/9217835.

Article  PubMed  PubMed Central  Google Scholar 

Maroyi A, Thonn. Gardenia ternifolia Schum. &. (Rubiaceae): Review of medicinal uses, phytochemistry and biological activities. Inter J Res Pharm Sci. 2020;11:5876–85. . https://doi.org/10.26452/ijrps.v11i4.3238.

Article  CAS  Google Scholar 

Nguetsa Sakou D, Galani Tietcheu BR. Protective effects of leaf aqueous extracts from Gardenia ternifolia Schumach. on alcoholic liver disease in Wistar rats. J Ayurveda Integr Med. 2024;15(1):100851. https://doi.org/10.1016/j.jaim.2023.100851.

Article  PubMed  PubMed Central  Google Scholar 

Agbodjento E, Klotoé JR, Dramane G, Dougnon TV, Ategbo JM. Gardenia ternifolia Schumach. & Thonn.: revue sur les aspects ethnobotanique, ethnopharmacologique, phytochimique et toxicologique. Int J Biol Chem Sci. 2018;12(6):2922–32.

Article  CAS  Google Scholar 

Nyemb JN, Tchuenguem RT, Venditti A, Tchinda AT, Henoumont C, Talla E, Iqbal SLJ. Antimicrobial and α-glucosidase inhibitory activities of chemical constituents from Gardenia aqualla (Rubiaceae). Nat Prod Res. 2022;36(24):6369–74. n10.1080/14786419.2022.2031187.

Article  CAS  PubMed  Google Scholar 

Nyemb JN, Magnibou LM, Talla E, Tchinda AT, Tchuenguem RT, Henoumont C, Mbafor JT. Lipids constituents from Gardenia aqualla stapf & hutch. Open Chem. 2018;16(1):371–6.

Article  CAS  Google Scholar 

Nyemb JN, Bayiha Ba Njock G, Demissie TB, Ombito JO, Ejaz SA, Attaullah HM, Henoumont C, Laurent S, Tchinda AT, Talla E, Iriti M. Bioactive constituents from Gardenia aqualla (Rubiaceae) stem bark as promising antibacterial agents: In vitro and in silico insights. Microb Pathog. 2026;210:108182.

Article  CAS  PubMed  Google Scholar 

Bernard D, Hassana Y, Djaouda M, Mathieu M, Romeo WB, Benoît K, Wahab AT. Antibacterial effects of a new triterpenoid saponin from roots of Gardenia ternifolia Schumach. Results Chem. 2022;4:100366. Thonn (Rubiaceae.

Article  CAS  Google Scholar 

Kara M, Haoudi N, Tahiri NEH, Rhebbar FZ, Mernissi RE, Assouguem A, Slali H, Bahhou J. Chemical profiling, antioxidant and antimicrobial activities, and in silico evaluation of Gardenia jasminoides essential oil. Plants. 2025;14(7):1055. https://doi.org/10.3390/plants14071055.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ngalemo CB, Tchiengang Tchoua GL, Bony FN, Tsawo BG, Mbopi PY, et al. Polyphenolic and flavonoids contents and antibacterial activity of hydro-ethanolic and aqueous extract of fresh leaves of Gardenia aqualla. Int J Pharm Chem. 2023;8(6):75–81. https://doi.org/10.11648/j.ijpc.20220806.12.

Article  CAS  Google Scholar 

Tachado SD, Gerold P, Schwarz R, Novakovic S, McConville M, Schofield L. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc Natl Acad Sci. 1997;94(8):4022–7. https://doi.org/10.1073/pnas.94.8.4022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majumder HK, de Souza W, Chang KP. Target Identification and Intervention Strategies against Kinetoplastid Protozoan Parasites. Mol Biol Int. 2011;2011:185413. https://doi.org/10.4061/2011/185413.

Article  PubMed  PubMed Central  Google Scholar 

Trager W, Jensen JB. Human malaria parasites in continuous culture. Science. 1976;193:673–5.

Article  CAS  PubMed  Google Scholar 

Lambros C, Vanderberg JP. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979;65:418–20.

Article  CAS  PubMed  Google Scholar 

Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob Agents Chemother. 2004;48:1803–6. https://doi.org/10.1128/AAC.48.5.1803.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siqueira-Neto JL, Song OR, Oh H, Sohn JH, Yang G, et al. Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. PLoS Negl Trop Dis. 2010;4(5):e675. https://doi.org/10.1371/journal.pntd.0000675.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowling T, Mercer L, Don R, Jacobs R, Nare B. Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis. Int J Parasitol Drugs Drug Resist. 2012;2:262–70.

Article  PubMed  PubMed Central  Google Scholar 

Jansen O, Angenot L, Tits M, Nicolas JP, De Mol P, Nikiema JB, Frederich M. Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties. J Ethnopharmacol. 2010;130(1):143–50.

Article  PubMed  Google Scholar 

El Tahir A, Satti GMH, Khalid SA. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell. J Ethnopharmacol. 1999;64:227–33.

Article  PubMed  Google Scholar 

Suksamrarn A, Tanachatchairatana T, Kanokmedhakul S. Antiplasmodial triterpenes from twigs of Gardenia saxatilis. J Ethnopharmacol. 2003;88:275–7.

Article  CAS  PubMed  Google Scholar 

Sülsen VP, Cazorla SI, Frank FM, Redko FC, Anesini CA, Coussio JD, Malchiodi EL, Martino VS, Mischietti LV. Trypanocidal and leishmanicidal activities of flavonoids from Argentine medicinal plants. Am J Trop Med Hyg. 2007;77:654–9.

Article  PubMed  Google Scholar 

Grecco Sdos S, Felix MJ, Lago JH, Pinto GE, Tempone AG, Romoff P, Ferreira JMP, Sartorelli P. Anti-trypanosomal phenolic derivatives from Baccharis uncinella. Nat Prod Commun. 2014;9:171–3.

PubMed  Google Scholar 

Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med. 2016;7(3):360–6. https://doi.org/10.1016/j.jtcme.2016.11.003.

Article  PubMed  PubMed Central  Google Scholar 

Mansourabadi AM, Sadeghi HM, Razavi N, Rezvani E. Anti-inflammatory and analgesic properties of salvigenin, a Salvia officinalis flavonoid extract. Adv Herb Med. 2015;1:31–41.

CAS  Google Scholar 

Mansourizadeh F, Houri Sepehri, Khoee S, Farimani MM, Delphi L, Tousi MS. Designing salvigenin-loaded mPEG-b-PLGA@Fe₃O₄ nanoparticles for enhanced anti-cancer effects on breast cancer ce