New oral anticoagulants and hepatocellular carcinoma among patients with HBV, HCV, and alcoholic liver diseases: a nationwide cohort study

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–263

PubMed  Google Scholar 

Health Promotion Administration MoHaW, Taiwan Cancer registry annual report, 2022, Taiwan. 2024. p. 40–1.

Liao SH, Chen CL, Hsu CY, Chien KL, Kao JH, Chen PJ, et al. Long-term effectiveness of population-wide multifaceted interventions for hepatocellular carcinoma in Taiwan. J Hepatol. 2021;75(1):132–141

Article  PubMed  Google Scholar 

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):6

Article  PubMed  Google Scholar 

Hagström H, Thiele M, Sharma R, Simon TG, Roelstraete B, Söderling J, et al. Risk of cancer in biopsy-proven alcohol-related liver disease: a population-based cohort study of 3410 persons. Clin Gastroenterol Hepatol. 2022;20(4):918–29.e8

Article  PubMed  Google Scholar 

Lin CW, Lin CC, Mo LR, Chang CY, Perng DS, Hsu CC, et al. Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis. J Hepatol. 2013;58(4):730–735

Article  CAS  PubMed  Google Scholar 

Polpichai N, Saowapa S, Danpanichkul P, Chan SY, Sierra L, Blagoie J, et al. Beyond the liver: a comprehensive review of strategies to prevent hepatocellular carcinoma. J Clin Med. 2024;13(22):6770

Article  CAS  PubMed  PubMed Central  Google Scholar 

Unruh D, Horbinski C. Beyond thrombosis: the impact of tissue factor signaling in cancer. J Hematol Oncol. 2020;13(1):93

Article  PubMed  PubMed Central  Google Scholar 

Aleksandrowicz K, Hempel D, Polityńska B, Wojtukiewicz AM, Honn KV, Tang DG, et al. The complex role of thrombin in cancer and metastasis: focus on interactions with the immune system. Semin Thromb Hemost. 2024;50(3):462–473

Article  CAS  PubMed  Google Scholar 

Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, et al. Warfarin blocks gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. Cancer Res. 2015;75(18):3699–3705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Z, Ling LR, Ng M, Matlub L, Mehta K, Linus RA, et al. The effect of anticoagulants on oral squamous cell carcinoma: a systematic review. J Oral Pathol Med. 2021;50(1):118–121

Article  PubMed  Google Scholar 

Al-Azzawi HMA, Hamza SA, Lin Z, Paolini R, McCullough M, Yap T, et al. Potential effects of anticoagulants in preclinical mice models of oral cancer: a systematic review. Oral Dis. 2024;30(3):962–965

Article  PubMed  Google Scholar 

Haaland GS, Falk RS, Straume O, Lorens JB. Association of warfarin use with lower overall cancer incidence among patients older than 50 years. JAMA Intern Med. 2017;177(12):1774–1780

Article  PubMed  PubMed Central  Google Scholar 

Najidh S, Versteeg HH, Buijs JT. A systematic review on the effects of direct oral anticoagulants on cancer growth and metastasis in animal models. Thromb Res. 2020;187:18–27

Article  CAS  PubMed  Google Scholar 

Buijs JT, Laghmani EH, van den Akker RFP, Tieken C, Vletter EM, van der Molen KM, et al. The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice. J Thromb Haemost. 2019;17(6):951–963

Article  PubMed  PubMed Central  Google Scholar 

Featherby S, Xiao YP, Ettelaie C, Nikitenko LL, Greenman J, Maraveyas A. Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Sci Rep. 2019;9(1):6272

Article  PubMed  PubMed Central  Google Scholar 

O’Leary JG, Greenberg CS, Patton HM, Caldwell SH. AGA clinical practice update: coagulation in cirrhosis. Gastroenterology. 2019;157(1):34-43.e1

Article  PubMed  Google Scholar 

Hsieh CY, Su CC, Shao SC, Sung SF, Lin SJ, Kao Yang YH, et al. Taiwan’s national health insurance research database: past and future. Clin Epidemiol. 2019;11:349–358

Article  PubMed  PubMed Central  Google Scholar 

Tsan YT, Lee CH, Ho WC, Lin MH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis C virus infection. J Clin Oncol. 2013;31(12):1514–1521

Article  PubMed  Google Scholar 

Shen YC, Hsu HC, Lin TM, Chang YS, Hu LF, Chen LF, et al. H1-Antihistamines reduce the risk of hepatocellular carcinoma in patients with hepatitis B virus, hepatitis C virus, or dual hepatitis B virus-hepatitis C virus infection. J Clin Oncol. 2022;40(11):1206–1219

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu CY, Ho HJ, Wu CY, Chen YJ, Lee TY, Hsu YC, et al. Association between proton pump inhibitor use and mortality in patients with hepatocellular carcinoma receiving tyrosine kinase inhibitor. Gut. 2020;70(8):1598–1599

Article  Google Scholar 

Johnson ES, Bartman BA, Briesacher BA, Fleming NS, Gerhard T, Kornegay CJ, et al. The incident user design in comparative effectiveness research. Pharmacoepidemiol Drug Saf. 2013;22(1):1–6

Article  PubMed  Google Scholar 

Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. J Clin Oncol. 2009;27(29):4834–4838

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castle J, Blower E, Bundred NJ, Harvey JR, Thachil J, Marshall A, et al. Rivaroxaban compared to no treatment in ER-negative stage I-III early breast cancer patients (the TIP Trial): study protocol for a phase II preoperative window-of-opportunity study design randomised controlled trial. Trials. 2020;21(1):749

Article  CAS  PubMed  PubMed Central  Google Scholar 

DeFeo K, Hayes C, Chernick M, Ryn JV, Gilmour SK. Use of dabigatran etexilate to reduce breast cancer progression. Cancer Biol Ther. 2010;10(10):1001–1008

Article  CAS  PubMed  Google Scholar 

Graf C, Wilgenbus P, Pagel S, Pott J, Marini F, Reyda S, et al. Myeloid cell-synthesized coagulation factor X dampens antitumor immunity. Sci Immunol. 2019;4(39):eaaw8405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiramoto K, Akita N, Nishioka J, Suzuki K. Edoxaban, a factor Xa-specific direct oral anticoagulant, significantly suppresses Tumor growth in colorectal cancer Colon26-inoculated BALB/c Mice. TH Open. 2023;7(1):e1–e13

Article  PubMed  PubMed Central  Google Scholar 

Rees PA, Castle J, Clouston HW, Lamb R, Singh U, Duff SE, et al. The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer. Cancer Med. 2023;12(16):1714–17192

Article  Google Scholar 

Airola C, Pallozzi M, Cerrito L, Santopaolo F, Stella L, Gasbarrini A, et al. Microvascular thrombosis and liver fibrosis progression: mechanisms and clinical applications. Cells. 2023;12(13):1712

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zanetto A, Campello E, Bulato C, Gavasso S, Saggiorato G, Shalaby S, et al. More pronounced hypercoagulable state and hypofibrinolysis in patients with cirrhosis with versus without HCC. Hepatol Commun. 2021;5(12):1987–2000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zanetto A, Campello E, Pelizzaro F, Farinati F, Burra P, Simioni P, et al. Haemostatic alterations in patients with cirrhosis and hepatocellular carcinoma: laboratory evidence and clinical implications. Liver Int. 2022;42(6):1229–1240

Article  CAS  PubMed  Google Scholar 

Lee KC, Hsu WF, Hsieh YC, Chan CC, Yang YY, Huang YH, et al. Dabigatran reduces liver fibrosis in Thioacetamide-injured rats. Dig Dis Sci. 2019;64(1):102–112

Article  CAS 

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