Prevalence and associated factors of metabolic dysfunction-associated steatotic liver disease in Taiwan, 2001–2021

Qiu S, Cai J, Yang Z, He X, Xing Z, Zu J, et al. Trends in hepatocellular carcinoma mortality rates in the US and projections through 2040. JAMA Netw Open. 2024;7(11): e2445525

Article  PubMed  PubMed Central  Google Scholar 

Terrault NA, Francoz C, Berenguer M, Charlton M, Heimbach J. Liver transplantation 2023: status report, current and future challenges. Clin Gastroenterol Hepatol. 2023;21(8):2150–2166

Article  CAS  PubMed  Google Scholar 

Alqahtani SA, Chan WK, Yu ML. Hepatic outcomes of nonalcoholic fatty liver disease including cirrhosis and hepatocellular carcinoma. Clin Liver Dis. 2023;27(2):211–223

Article  PubMed  Google Scholar 

Wong VW, Ekstedt M, Wong GL, Hagstrom H. Changing epidemiology, global trends and implications for outcomes of NAFLD. J Hepatol. 2023;79(3):842–852

Article  PubMed  Google Scholar 

Younossi ZM, Blissett D, Blissett R, Henry L, Stepanova M, Younossi Y, et al. The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe. Hepatology. 2016;64(5):1577–1586

Article  PubMed  Google Scholar 

Chen YT, Chen TI, Yin SC, Huang CW, Huang JF, Lu SN, et al. Prevalence, proportions of elevated liver enzyme levels, and long-term cardiometabolic mortality of patients with metabolic dysfunction-associated steatotic liver disease. J Gastroenterol Hepatol. 2024;39(9):1939–1949

Article  CAS  PubMed  Google Scholar 

Huang JF, Tsai PC, Yeh ML, Huang CF, Huang CI, Hsieh MH, et al. Risk stratification of non-alcoholic fatty liver disease across body mass index in a community basis. J Formos Med Assoc. 2020;119(1 Pt 1):89–96

Article  PubMed  Google Scholar 

Younossi ZM, Zelber-Sagi S, Kuglemas C, Lazarus JV, Paik A, de Avila L, et al. Association of food insecurity with MASLD prevalence and liver-related mortality. J Hepatol. 2025;82(2):203–210

Article  CAS  PubMed  Google Scholar 

Ji H, Cheng S, Heart-Liver Axis Research C. Sex differences in prevalence and prognosis of steatotic liver disease phenotypes: biological sex matters. J Hepatol. 2024;80(2):e68–e69

Article  PubMed  Google Scholar 

Georgieva M, Xenodochidis C, Krasteva N. Old age as a risk factor for liver diseases: modern therapeutic approaches. Exp Gerontol. 2023;184: 112334

Article  CAS  PubMed  Google Scholar 

Paik JM, Duong S, Zelber-Sagi S, Lazarus JV, Henry L, Younossi ZM. Food insecurity, low household income, and low education level increase the risk of having metabolic dysfunction-associated fatty liver disease among adolescents in the United States. Am J Gastroenterol. 2024;119(6):1089–1101

Article  CAS  PubMed  Google Scholar 

Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966–1986

Article  PubMed  PubMed Central  Google Scholar 

Stefan N, Schulze MB. Metabolic health and cardiometabolic risk clusters: implications for prediction, prevention, and treatment. Lancet Diabetes Endocrinol. 2023;11(6):426–440

Article  CAS  PubMed  Google Scholar 

Dabbah S, Ben Yakov G, Kaufmann MI, Cohen-Ezra O, Likhter M, Davidov Y, et al. Predictors of advanced liver fibrosis and the performance of fibrosis scores: lean compared to non-lean metabolic dysfunction-associated steatotic liver disease (MASLD) patients. Minerva Gastroenterol (Torino). 2024;70(3):322–331

PubMed  Google Scholar 

Dong R, Tian T, Luo Z, Chang D, Xue H, Qu S, et al. Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease. Nutr Metab Cardiovasc Dis. 2024. https://doi.org/10.1016/j.numecd.2024.103797

Article  PubMed  Google Scholar 

Shih CI, Wu KT, Hsieh MH, Yang JF, Chen YY, Tsai WL, et al. Severity of fatty liver is highly correlated with the risk of hypertension and diabetes: a cross-sectional and longitudinal cohort study. Hepatol Int. 2024;18(1):138–154

Article  PubMed  Google Scholar 

Feng YA, Chen CY, Chen TT, Kuo PH, Hsu YH, Yang HI, et al. Taiwan biobank: a rich biomedical research database of the Taiwanese population. Cell Genom. 2022;2(11): 100197

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu X, Tsai SP, Tsao CK, Chiu ML, Tsai MK, Lu PJ, et al. Cohort profile: the Taiwan MJ cohort: half a million Chinese with repeated health surveillance data. Int J Epidemiol. 2017;46(6):1744-g

Article  Google Scholar 

Rosenberg PS, Check DP, Anderson WF. A web tool for age-period-cohort analysis of cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev. 2014;23(11):2296–2302

Article  PubMed  PubMed Central  Google Scholar 

Kan C, Zhang K, Wang Y, Zhang X, Liu C, Ma Y, et al. Global burden and future trends of metabolic dysfunction-associated steatotic liver disease: 1990–2021 to 2045. Ann Hepatol. 2025;30(2): 101898

Article  PubMed  Google Scholar 

Tobari M, Hashimoto E. Characteristic features of nonalcoholic fatty liver disease in Japan with a focus on the roles of age, sex and body mass index. Gut Liver. 2020;14(5):537–545

Article  PubMed  PubMed Central  Google Scholar 

Alnimer Y, Alnimer T. Prediction of liver steatosis and fibrosis based on clinical variables using a large national survey database. Can J Gastroenterol Hepatol. 2023;2023:1791500

Article  PubMed  PubMed Central  Google Scholar 

He QJ, Li YF, Zhao LT, Lin CT, Yu CY, Wang D. Recent advances in age-related metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol. 2024;30(7):652–662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng G, Targher G, Byrne CD, Yilmaz Y, Wai-Sun Wong V, Adithya Lesmana CR, et al. Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP Rep. 2025;7(3): 101271

Article  PubMed  Google Scholar 

Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15(1):11–20

Article  PubMed  Google Scholar 

Lonardo A, Nascimbeni F, Ballestri S, Fairweather D, Win S, Than TA, et al. Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps. Hepatology. 2019;70(4):1457–1469

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yip TC, Vilar-Gomez E, Petta S, Yilmaz Y, Wong GL, Adams LA, et al. Geographical similarity and differences in the burden and genetic predisposition of NAFLD. Hepatology. 2023;77(4):1404–1427

Article  PubMed  Google Scholar 

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