Miao L, et al. Current status and future trends of the global burden of MASLD. Trends Endocrinol Metab. 2024;35(8):697–707

Article  CAS  PubMed  Google Scholar 

Rinella ME, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023;79(6):1542–1556

Article  CAS  PubMed  Google Scholar 

European Association for the Study of the, L., D. European Association for the Study of, and O. European Association for the Study of, EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol, 2024. 81(3): p. 492–542.

Targher G, Byrne CD, Tilg H. MASLD: a systemic metabolic disorder with cardiovascular and malignant complications. Gut. 2024;73(4):691–702

Article  CAS  PubMed  Google Scholar 

Loomba R, Friedman SL, Shulman GI. Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell. 2021;184(10):2537–2564

Article  CAS  PubMed  PubMed Central  Google Scholar 

Younossi ZM, et al. Lifestyle interventions in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2023;20(11):708–722

Article  CAS  PubMed  Google Scholar 

Chen VL, et al. Resmetirom therapy for metabolic dysfunction-associated steatotic liver disease: October 2024 updates to AASLD Practice Guidance. Hepatology. 2025;81(1):312–320

Article  PubMed  Google Scholar 

Loomba R, et al. Semaglutide 2.4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial. The Lancet Gastroenterology & Hepatology. 2023;8(6):511–522

Article  CAS  Google Scholar 

Liu W, et al. SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8(+) T cell activation. Cell Metab. 2024;36(11):2489

Article  CAS  PubMed  Google Scholar 

Azzu V, et al. Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease. Gastroenterology. 2020;158(7):1899–1912

Article  CAS  PubMed  Google Scholar 

Huttasch M, Roden M, Kahl S. Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? Metabolism. 2024;157: 155937

Article  CAS  PubMed  Google Scholar 

Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023;78(5):1048–1062

Article  CAS  PubMed  Google Scholar 

Huang N, et al. Novel insight into perirenal adipose tissue: A neglected adipose depot linking cardiovascular and chronic kidney disease. World J Diabetes. 2020;11(4):115–125

Article  PubMed  PubMed Central  Google Scholar 

Li P, et al. Perirenal adipose afferent nerves sustain pathological high blood pressure in rats. Nat Commun. 2022;13(1):3130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen H, et al. Perirenal Adipose Tissue and Hypertension: Observational and Genetic Analyses. Hypertension. 2025;82(11):1809–1821

Article  CAS  PubMed  Google Scholar 

Sakers A, et al. Adipose-tissue plasticity in health and disease. Cell. 2022;185(3):419–446

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourin P, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013;15(6):641–648

Article  PubMed  PubMed Central  Google Scholar 

Nahmgoong H, et al. Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics. Cell Metab. 2022;34(3):458-472 e6

Article  CAS  PubMed  Google Scholar 

Divoux A, et al. Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing. Am J Physiol Cell Physiol. 2024;326(4):C1248–C1261

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lecoutre S, et al. Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health. Nat Rev Endocrinol. 2025;21(5):272–288

Article  CAS  PubMed  Google Scholar 

Qin Y, et al. An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity. Adv Sci (Weinh). 2023;10(20): e2207334

Article  PubMed  PubMed Central  Google Scholar 

Louwen F, et al. Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells. Obes Rev. 2018;19(7):888–904

Article  CAS  PubMed  Google Scholar 

Eirin A, et al. Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changes. Cell Death Dis. 2024;15(6):387

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, et al. Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells. Diabetes. 2022;71(2):321–328

Article  CAS  PubMed  Google Scholar 

Zhao H, et al. Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue. Diabetes. 2018;67(2):235–247

Article  CAS  PubMed  Google Scholar 

Zhang Q, et al. ADSCs-exo attenuates hepatic ischemia-reperfusion injury after hepatectomy by inhibiting endoplasmic reticulum stress and inflammation. J Cell Physiol. 2023;238(3):659–669

Article  CAS  PubMed  Google Scholar 

Wu B, et al. ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. Stem Cell Res Ther. 2022;13(1):494

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinte LC, et al. Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature. 2024;636(8042):457–465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walewska A, et al. Mesenchymal stem cells under epigenetic control - the role of epigenetic machinery in fate decision and functional properties. Cell Death Dis. 2023;14(11):720

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie S, et al. Aging and obesity prime the methylome and transcriptome of adipose stem cells for disease and dysfunction. FASEB J. 2023;37(3): e22785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bunnell BA, et al. Adipose-derived stem cells: isolation, expansion and differentiation. Methods. 2008;45(2):115–120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peta KT, Pepper MS, Ambele MA. Isolation and Characterization of Mouse Adipose-Derived Stromal/Stem Cells. Methods Mol Biol. 2025;2938:119–123