WHO, Hepatitis B. 2024; https://www.who.int/news-room/fact-sheets/detail/hepatitis-b

World Health Organization. Global hepatitis report 2024: action for access in low- and middle-income countries. Geneva, 2024.

Chen J, Jia J, Zhuang H, Zhang W, Yang JM, Tanwandee T, et al. Assessing pricing and affordability of HBV treatment in Asia-Pacific region: a barrier to elimination. Hepatol Int. 2025;19(2):349–357

Article  PubMed  PubMed Central  Google Scholar 

Duan M, Xiao H, Shi M, Xie Y, Zhao P, Li S, et al. Significant liver histological change is common in HBeAg-positive chronic hepatitis B with normal ALT. BMC Infect Dis. 2024;24(1):723

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kennedy PT, Allweiss L, Bertoletti A, Cornberg M, Gehring AJ, Guidotti LG, et al. Scientific and medical evidence informing expansion of hepatitis B treatment guidelines. Lancet Gastroenterol Hepatol. 2025;10(10):941–951

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gill US, Appleby VJ, Lens S. ‘What is new in hepatitis B’. Frontline Gastroenterology 2026;17:161–171

Chen J, Lau G. HBV “Viral Elimination” in the Asia-Pacific region: current status and challenges. Clin Liver Dis (Hoboken). 2024;23(1): e0132

PubMed  PubMed Central  Google Scholar 

Lok AS, Heathcote EJ, Hoofnagle JH. Management of hepatitis B: 2000--summary of a workshop. Gastroenterology. 2001;120(7):1828–1853

Article  CAS  PubMed  Google Scholar 

de Franchis R, Hadengue A, Lau G, Lavanchy D, Lok A, McIntyre N, et al. EASL International on Hepatitis B. 13-14 September, 2002 Geneva, Switzerland. Switzerland Consensus statement (long version). J Hepatol. 2003;39(Suppl 1):S3–S25

PubMed  Google Scholar 

Liaw YF, Leung N, Kao JH, Piratvisuth T, Gane E, Han KH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int. 2008;2(3):263–83

Article  PubMed  PubMed Central  Google Scholar 

Liaw YF, Kao JH, Piratvisuth T, Chan HL, Chien RN, Liu CJ, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int. 2012;6(3):531–61

Article  PubMed  Google Scholar 

Sarin S, Kumar M, Lau GK, Abbas Z, Chan HL, Chen CJ, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int. 2016;10(1):1–98

Article  CAS  PubMed  Google Scholar 

Liaw YF, Leung N, Guan R, Lau GK, Merican I, Asian-Pacific Consensus Working Parties on Hepatitis B. Asian-Pacific consensus statement on the management of chronic Hepatitis B: an update. J Gastroenterol Hepatol. 2003;18(3):239–245

Article  PubMed  Google Scholar 

Liaw YF, Leung N, Guan R, Lau GK, Merican I, McCaughan G, et al. Gane E Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update. Liver Int. 2005;25(3):472–89

Article  PubMed  Google Scholar 

Liaw YF, Sung JJ, Chow WC, Farrell G, Lee CZ, Yuen H, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004;351(15):1521–31

Article  CAS  PubMed  Google Scholar 

Lau G, Carman W, Locarnini S, Okuda K, Lu ZM, Williams R. Lam S Treatment of chronic hepatitis B virus infection: an Asia-Pacific perspective. J Gastroenterol Hepatol. 1999;14(1):3–12

Article  CAS  PubMed  Google Scholar 

Chen GF, Wang C, Lau G. Treatment of chronic hepatitis B infection-2017. Liver Int. 2017;37(Suppl 1):59–66

Article  CAS  PubMed  Google Scholar 

Roade L, Riveiro-Barciela M, Esteban R, Buti M. Long-term efficacy and safety of nucleos(t)ides analogues in patients with chronic hepatitis B. Ther Adv Infect Dis. 2021;8: 2049936120985954

CAS  PubMed  PubMed Central  Google Scholar 

Lim SG, Baumert TF, Boni C, Gane E, Levrero M, Lok AS, et al. The scientific basis of combination therapy for chronic hepatitis B functional cure. Nat Rev Gastroenterol Hepatol. 2023;20(4):238–53

Article  CAS  PubMed  Google Scholar 

Sandmann L. Toward functional cure of hepatitis B: Is combination therapy the key? J Hepatol. 2025;83(1):271–272

Article  PubMed  Google Scholar 

Eslam M, Fan JG, Yu ML, Wong VW, Cua IH, Liu CJ, et al. The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease. Hepatol Int. 2025;19(2):261–301

Article  PubMed  Google Scholar 

Wong GL, Hui VW, Yip TC, Liang LY, Zhang X, Tse YK, et al. Universal HBV vaccination dramatically reduces the prevalence of HBV infection and incidence of hepatocellular carcinoma. Aliment Pharmacol Ther. 2022;56(5):869–77

Article  CAS  PubMed  Google Scholar 

Lau GK, Lai CL, Wu PC. The natural history of chronic hepatitis B infection. Hong Kong Med J. 1997;3(3):283–288

PubMed  Google Scholar 

Jeng WJ, Papatheodoridis GV, Lok ASF. Hepatitis B. Lancet. 2023;401(10381):1039–1052

Article  CAS  PubMed  Google Scholar 

World Health Organization. Hepatitis B vaccines: WHO position paper - July 2017. Wkly Epidemiol Rec. 2017;92(27):369–392

Google Scholar 

FitzSimons D, Hendrickx G, Vorsters A, Van Damme P. Hepatitis B vaccination: a completed schedule enough to control HBV lifelong? Vaccine. 2013;31(4):584–590 (Milan, Italy, 17-18 November 2011.)

Article  PubMed  Google Scholar 

Di Lello FA, Martinez AP, Flichman DM. Insights into induction of the immune response by the hepatitis B vaccine. World J Gastroenterol. 2022;28(31):4249–4262

Article  CAS  PubMed  PubMed Central  Google Scholar 

McMahon BJ, Dentinger CM, Bruden D, Zanis C, Peters H, Hurlburt D, et al. Antibody levels and protection after hepatitis B vaccine: results of a 22-year follow-up study and response to a booster dose. J Infect Dis. 2009;200(9):1390–6

Article  CAS  PubMed  Google Scholar 

Bello N, Hudu SA, Alshrari AS, Imam MU, Jimoh AO. Overview of Hepatitis B vaccine non-response and associated B cell amnesia: a scoping review. Pathogens. 2024;13(7):554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chancharoenthana W, Traitanon O, Leelahavanichkul A, Ronco C. Optimizing hepatitis B vaccination in chronic kidney disease: a comprehensive scoping review of strategies across CKD stages, dialysis, and transplant populations. Ren Fail. 2025;47(1): 2541873

Article  PubMed  PubMed Central  Google Scholar 

Catherine FX, Piroth L. Hepatitis B virus vaccination in HIV-infected people: a review. Hum Vaccin Immunother. 2017;13(6):1–10

Article  PubMed  PubMed Central  Google Scholar 

Beltrami EM, Williams IT, Shapiro CN, Chamberland ME. Risk and management of blood-borne infections in health care workers. Clin Microbiol Rev. 2000;13(3):385–407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schillie S, Murphy TV, Fenlon N, Ko S, Ward JW. Update: shortened interval for postvaccination serologic testing of infants born to Hepatitis B-infected mothers. MMWR Morb Mortal Wkly Rep. 2015;64(39):1118–1120

Article  PubMed  Google Scholar 

Hou J, Cui F, Ding Y, Dou X, Duan Z, Han G, et al. Management algorithm for interrupting mother-to-child transmission of hepatitis B Virus. Clin Gastroenterol Hepatol. 2019;17(10):1929–36.e1

Article  PubMed  Google Scholar 

Nelson NP, Jamieson DJ, Murphy TV. Prevention of perinatal Hepatitis B virus transmission. J Pediatr Infect Dis Soc. 2014;3(Suppl 1(Suppl 1)):S7–S12

Article