Goldblum JR, Weiss SW, Folpe AL. Enzinger and Weiss’s soft tissue tumors E-Book. Elsevier Health Sciences; 2013.
Arifi S, Belbaraka R, Rahhali R, Ismaili N. Treatment of Adult Soft Tissue Sarcomas: An Overview. Rare Cancers Ther. 2015;3(1):69–87.
Article PubMed PubMed Central Google Scholar
Bleloch JS, Ballim RD, Kimani S, Parkes J, Panieri E, Willmer T, et al. Managing sarcoma: where have we come from and where are we going? Ther Adv Med Oncol. 2017;9(10):637–59.
Article CAS PubMed PubMed Central Google Scholar
Hansen T, Katenkamp K, Brodhun M, Katenkamp D. Low-grade fibrosarcoma–report on 39 not otherwise specified cases and comparison with defined low-grade fibrosarcoma types. Histopathology. 2006;49(2):152–60.
Article CAS PubMed Google Scholar
Tan MC, Brennan MF, Kuk D, Agaram NP, Antonescu CR, Qin LX, et al. Histology-based classification predicts pattern of recurrence and improves risk stratification in primary retroperitoneal sarcoma. Ann Surg. 2016;263(3):593–600.
Article PubMed PubMed Central Google Scholar
von Mehren M, Kane JM, Agulnik M, Bui MM, Carr-Ascher J, Choy E, et al. Soft Tissue Sarcoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022;20(7):815–33.
Seddon B, Strauss SJ, Whelan J, Leahy M, Woll PJ, Cowie F, et al. Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial. Lancet Oncol. 2017;18(10):1397–410.
Article CAS PubMed PubMed Central Google Scholar
Tap WD, Wagner AJ, Schöffski P, Martin-Broto J, Krarup-Hansen A, Ganjoo KN, et al. Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial. JAMA. 2020;323(13):1266–76.
Article CAS PubMed PubMed Central Google Scholar
Coindre JM, Terrier P, Bui NB, Bonichon F, Collin F, Le Doussal V, et al. Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol. 1996;14(3):869–77.
Article CAS PubMed Google Scholar
Italiano A, Mathoulin-Pelissier S, Cesne AL, Terrier P, Bonvalot S, Collin F, et al. Trends in survival for patients with metastatic soft-tissue sarcoma. Cancer. 2011;117(5):1049–54.
Meyer M, Seetharam M. First-Line Therapy for Metastatic Soft Tissue Sarcoma. Curr Treat Options Oncol. 2019;20(1):6.
Carbonnaux M, Brahmi M, Schiffler C, Meeus P, Sunyach MP, Bouhamama A, et al. Very long-term survivors among patients with metastatic soft tissue sarcoma. Cancer Med. 2019;8(4):1368–78.
Article CAS PubMed PubMed Central Google Scholar
Coley WB. II. Contribution to the Knowledge of Sarcoma. Ann Surg. 1891;14(3):199–220.
Article CAS PubMed PubMed Central Google Scholar
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol. 2017;18(11):1493–501.
Article CAS PubMed PubMed Central Google Scholar
Groisberg R, Hong DS, Behrang A, Hess K, Janku F, Piha-Paul S, et al. Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials. J Immunother Cancer. 2017;5(1):100.
Article PubMed PubMed Central Google Scholar
Burgess MA, Bolejack V, Schuetze S, Tine BAV, Attia S, Riedel RF, et al. Clinical activity of pembrolizumab (P) in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated/pleomorphic liposarcoma (LPS): Final results of SARC028 expansion cohorts. J Clin Oncol. 2019;37(15suppl):11015.
Petitprez F, de Reyniès A, Keung EZ, Chen TW, Sun CM, Calderaro J, et al. B cells are associated with survival and immunotherapy response in sarcoma. Nature. 2020;577(7791):556–60.
Article CAS PubMed Google Scholar
Italiano A, Bellera C, D’Angelo S. PD1/PD-L1 targeting in advanced soft-tissue sarcomas: a pooled analysis of phase II trials. J Hematol Oncol. 2020;13(1):55.
Article CAS PubMed PubMed Central Google Scholar
Wood GE, Meyer C, Petitprez F, D’Angelo SP. Immunotherapy in Sarcoma: Current Data and Promising Strategies. Am Soc Clin Oncol Educ Book. 2024;44(3):e432234.
Cao Y, Wang W, Xu H, Yi H, Gao Y, Wan M, et al. Efficacy of immune checkpoint inhibitors in the treatment of soft tissue sarcoma: A systematic review and meta-analysis of clinical trials. Int Immunopharmacol. 2025;148:114070.
Article CAS PubMed Google Scholar
Kallen ME, Hornick JL. The 2020 WHO Classification: What’s New in Soft Tissue Tumor Pathology? Am J Surg Pathol. 2021;45(1):e1–23.
Deng J, Zeng W, Kong W, Shi Y, Mou X. The study of sarcoma microenvironment heterogeneity associated with prognosis based on an immunogenomic landscape analysis. Front Bioeng Biotechnol. 2020;8:1003.
Article PubMed PubMed Central Google Scholar
Subramanian A, Nemat-Gorgani N, Ellis-Caleo TJ, van Sears IDGP, Somani TJ. Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy. Nat Cancer. 2024;5(4):642–58.
Article CAS PubMed PubMed Central Google Scholar
Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L. Macrophages and Metabolism in the Tumor Microenvironment. Cell Metab. 2019;30(1):36–50.
Article CAS PubMed Google Scholar
Kloosterman DJ, Akkari L. Macrophages at the interface of the co-evolving cancer ecosystem. Cell. 2023;186(8):1627–51.
Article CAS PubMed Google Scholar
Pittet MJ, Michielin O, Migliorini D. Clinical relevance of tumour-associated macrophages. Nat Rev Clin Oncol. 2022;19(6):402–21.
Kather JN, Hörner C, Weis CA, Aung T, Vokuhl C, Weiss C, et al. CD163 + immune cell infiltrates and presence of CD54 + microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma. Sci Rep. 2019;9(1):9211.
Article PubMed PubMed Central Google Scholar
Smolle MA, Herbsthofer L, Goda M, Granegger B, Brcic I, Bergovec M, et al. Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma. Oncoimmunology. 2021;10(1):1896658.
Article PubMed PubMed Central Google Scholar
Hu C, Chen B, Huang Z, Liu C, Ye L, Wang C, et al. Comprehensive profiling of immune-related genes in soft tissue sarcoma patients. J Transl Med. 2020;18(1):337.
Article CAS PubMed PubMed Central Google Scholar
D’Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, et al. Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol. 2018;19(3):416–26.
Article PubMed PubMed Central Google Scholar
Klaver Y, Rijnders M, Oostvogels A, Wijers R, Smid M, Grünhagen D, et al. Differential quantities of immune checkpoint-expressing CD8 t cells in soft tissue sarcoma subtypes. J Immunother Cancer. 2020. https://doi.org/10.1136/jitc-2019-000271.
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