Bennett MI, Kaasa S, Barke A, et al. The IASP classification of chronic pain for ICD-11: chronic cancer-related pain. Pain. 2019;160(1):38–44. https://doi.org/10.1097/j.pain.0000000000001363.

Article  PubMed  Google Scholar 

Wang WL, Hao YH, Pang X, Tang YL. Cancer pain: molecular mechanisms and management. Mol Biomed. 2025;6(1):45. https://doi.org/10.1186/s43556-025-00289-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruano A, García-Torres F, Gálvez-Lara M, Moriana JA. Psychological and Non-Pharmacologic Treatments for Pain in Cancer Patients: A Systematic Review and Meta-Analysis. J Pain Symptom Manage. 2022;63(5):e505–20. https://doi.org/10.1016/j.jpainsymman.2021.12.021.

Article  PubMed  Google Scholar 

Snijders RAH, Brom L, Theunissen M, van den Beuken-van Everdingen MHJ. Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis. Cancers (Basel). 2023;15(3). https://doi.org/10.3390/cancers15030591.

Anekar AA, Hendrix JM, Cascella M. WHO Analgesic Ladder. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2025. StatPearls Publishing LLC. 2025.

Sanders JJ, Temin S, Ghoshal A, et al. Palliative Care for Patients With Cancer: ASCO Guideline Update. J Clin Oncol. 2024;42(19):2336–57. https://doi.org/10.1200/jco.24.00542.

Article  PubMed  Google Scholar 

Swarm RA, Youngwerth JM, Agne JL, et al. Adult Cancer Pain, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025;23(7). https://doi.org/10.6004/jnccn.2025.0032.

Geyer T, Le NS, Groissenberger I, Jutz F, Tschurlovich L, Kreye G. Systemic Anticancer Treatment Near the End of Life: a Narrative Literature Review. Curr Treat Options Oncol. 2023;24(10):1328–50. https://doi.org/10.1007/s11864-023-01115-x.

Article  PubMed  PubMed Central  Google Scholar 

Wu X, Qin F, Zhang Q, et al. Immunotherapy improved cancer related pain management in patients with advanced Hepato-Pancreatic Biliary Cancers: A propensity score-matched (PSM) analysis. Front Oncol. 2022;12:914591. https://doi.org/10.3389/fonc.2022.914591.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, Curigliano G, Yonemori K, et al. Patient-reported outcomes with trastuzumab deruxtecan in hormone receptor-positive, HER2-low or HER2-ultralow metastatic breast cancer: results from the randomized DESTINY-Breast06 trial. ESMO Open. 2025;10(5):105082. https://doi.org/10.1016/j.esmoop.2025.105082.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mansoor W, Joo S, Norquist JM, et al. Health-related quality-of-life analysis from KEYNOTE-590: pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer. Oncologist. 2024;29(10):e1324–35. https://doi.org/10.1093/oncolo/oyae087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spencer KL, van der Velden JM, Wong E, et al. Systematic Review of the Role of Stereotactic Radiotherapy for Bone Metastases. J Natl Cancer Inst. 2019;111(10):1023–32. https://doi.org/10.1093/jnci/djz101.

Article  PubMed  PubMed Central  Google Scholar 

Iannalfi A, Riva G, Ciccone L, Orlandi E. The role of particle radiotherapy in the treatment of skull base tumors. Front Oncol. 2023;13:1161752. https://doi.org/10.3389/fonc.2023.1161752.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Jiang W, Liao X, Wang D. Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions. Front Oncol. 2024;14:1421067. https://doi.org/10.3389/fonc.2024.1421067.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crews KR, Monte AA, Huddart R, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021;110(4):888–96. https://doi.org/10.1002/cpt.2149.

Article  CAS  PubMed  PubMed Central  Google Scholar 

George B, Minello C, Allano G, et al. Opioids in cancer-related pain: current situation and outlook. Support Care Cancer. 2019;27(8):3105–18. https://doi.org/10.1007/s00520-019-04828-8.

Article  PubMed  Google Scholar 

Mercadante S. Intravenous morphine for management of cancer pain. Lancet Oncol. 2010;11(5):484–9. https://doi.org/10.1016/s1470-2045(09)70350-x.

Article  CAS  PubMed  Google Scholar 

Formenti P, Umbrello M, Pignataro M, et al. Managing Severe Cancer Pain with Oxycodone/Naloxone Treatment: A Literature Review Update. J Pers Med. 2024;14(5). https://doi.org/10.3390/jpm14050483.

Wang DD, Ma TT, Zhu HD, Peng CB. Transdermal fentanyl for cancer pain: Trial sequential analysis of 3406 patients from 35 randomized controlled trials. J Cancer Res Ther. 2018;14(Supplement):S14–21. https://doi.org/10.4103/0973-1482.171368.

Article  PubMed  Google Scholar 

Coates S, Lazarus P, Hydrocodone. Oxycodone, and Morphine Metabolism and Drug-Drug Interactions. J Pharmacol Exp Ther. 2023;387(2):150–69. https://doi.org/10.1124/jpet.123.001651.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao YJ, Hou W, Kong XY, et al. Hydromorphone for cancer pain. Cochrane Database Syst Rev. 2016;10(10):Cd011108. https://doi.org/10.1002/14651858.CD011108.pub2.

Article  PubMed  PubMed Central  Google Scholar 

Reddy A, Haider A, Arthur J, et al. Levorphanol as a Second Line Opioid in Cancer Patients Presenting to an Outpatient Supportive Care Center: An Open-label Study. J Pain Symptom Manage. 2023;65(6):e683–90. https://doi.org/10.1016/j.jpainsymman.2023.01.013.

Article  PubMed  Google Scholar 

Liu MZ, Ma J, Li JD, et al. A Comparison of the Clinical Effectiveness Between Low-Dose Strong Opioids and Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Mild Cancer Pain: A Randomized Trial. J Pain Res. 2021;14:3411–9. https://doi.org/10.2147/jpr.S322893.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leiva-Vásquez O, Letelier LM, Rojas L, et al. Is Acetaminophen Beneficial in Patients With Cancer Pain Who are on Strong Opioids? A Randomized Controlled Trial. J Pain Symptom Manage. 2023;66(3):183–e921. https://doi.org/10.1016/j.jpainsymman.2023.05.002.

Article  PubMed  Google Scholar 

Page AJ, Spencer K, Mulvey MR, Laird BJ, Bennett MI. Non-steroidal anti-inflammatory drugs (NSAIDs) in cancer pain: A database analysis to determine recruitment feasibility for a clinical trial. Palliat Med. 2022;36(9):1440–5. https://doi.org/10.1177/02692163221122263.

Article  PubMed  PubMed Central  Google Scholar 

Szeto CC, Sugano K, Wang JG, APAGE/APLAR/APSDE, et al. Gut. 2020;69(4):617–29. https://doi.org/10.1136/gutjnl-2019-319300. /APSH/APSN/PoA recommendations.

Article  CAS  PubMed  Google Scholar 

Bally M, Dendukuri N, Rich B, et al. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ. 2017;357:j1909. https://doi.org/10.1136/bmj.j1909.

Article  PubMed  PubMed Central  Google Scholar 

Sohi G, Lao N, Caraceni A, et al. Nonopioid drug combinations for cancer pain: a systematic review. Pain Rep. 2022;7(2):e995. https://doi.org/10.1097/pr9.0000000000000995.

Article  PubMed  Google Scholar 

Bao H, Wu Z, Wang Q, et al. The efficacy of gabapentin combined with opioids for neuropathic cancer pain: a meta-analysis. Transl Cancer Res. 2021;10(2):637–44. https://doi.org/10.21037/tcr-20-2692.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sugimoto M, Takagi T, Suzuki R, et al. Mirogabalin vs pregabalin for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients. BMC Cancer. 2021;21(1):1319. https://doi.org/10.1186/s12885-021-09069-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulvey MR, Paley CA, Schuberth A, et al. Neuropathic Pain in Cancer: What Are the Current Guidelines? Curr Treat Options Oncol. 2024;25(9):1193–202. https://doi.org/10.1007/s11864-024-01248-7.