Zika Virus: Challenges and Advances on an Ongoing Threat

Dick GW, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46(5):509–20.

Article  PubMed  Google Scholar 

Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360(24):2536–43.

Article  PubMed  Google Scholar 

Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014;20(6):1085–6.

Article  PubMed  PubMed Central  Google Scholar 

Hennessey M, Fischer M, Staples JE. Zika Virus Spreads to New Areas - Region of the Americas, May 2015-January 2016. MMWR Morb Mortal Wkly Rep. 2016;65(3):55–8.

Article  PubMed  Google Scholar 

Fauci AS, Morens DM. Zika Virus in the Americas–Yet Another Arbovirus Threat. N Engl J Med. 2016;374(7):601–4.

Article  PubMed  Google Scholar 

Russell K, Oliver SE, Lewis L, Barfield WD, Cragan J, Meaney-Delman D, et al. Update: Interim Guidance for the Evaluation and Management of Infants with Possible Congenital Zika Virus Infection - United States, August 2016. MMWR Morb Mortal Wkly Rep. 2016;65(33):870–8.

Article  PubMed  Google Scholar 

Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB. Phylogeny of the genus Flavivirus. J Virol. 1998;72(1):73–83.

Article  PubMed  PubMed Central  Google Scholar 

Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18(3):411–5.

Article  PubMed  Google Scholar 

Liu ZY, Shi WF, Qin CF. The evolution of Zika virus from Asia to the Americas. Nat Rev Microbiol. 2019;17(3):131–9.

Article  PubMed  Google Scholar 

World Health Oganization. Countries and territories with current or previous Zika virus transmission: World Health Organization. 2023 [Available from: https://www.who.int/publications/m/item/countries-and-territories-with-current-or-previous-zika-virus-transmission

Pan American Health Organization. Zika: data and analysis 2026 [Available from: https://www.paho.org/en/arbo-portal/zika-data-and-analysis

McCain K, Vicco A, Morgenstern C, Rawson T, Naidoo TM, Bhatia S, et al. A systematic review and meta-analysis of Zika virus epidemiology. Nat Health. 2026;1(3):355–67.

Article  PubMed  PubMed Central  Google Scholar 

Husaini DC, Herbert AA, Rivera MZ, Nunez J, Coc A, Chiroma JH, Orisakwe OE. Beyond the epidemic curve: a critical systematic review of the structural, ecological, and viral determinants sustaining Chikungunya and Zika viruses in Latin America and the Caribbean. Ther Adv Infect Dis. 2026;13:20499361261438240.

PubMed  PubMed Central  Google Scholar 

Franca GV, Schuler-Faccini L, Oliveira WK, Henriques CM, Carmo EH, Pedi VD, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet. 2016;388(10047):891–7.

Article  PubMed  Google Scholar 

Moore CA, Staples JE, Dobyns WB, Pessoa A, Ventura CV, Fonseca EB, et al. Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians. JAMA Pediatr. 2017;171(3):288–95.

Article  PubMed  PubMed Central  Google Scholar 

Musso D, Ko AI, Baud D. Zika Virus Infection - After the Pandemic. N Engl J Med. 2019;381(15):1444–57.

Article  PubMed  Google Scholar 

Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD. Congenital Zika syndrome: A systematic review. PLoS ONE. 2020;15(12):e0242367.

Article  PubMed  PubMed Central  Google Scholar 

Brasil P, Nielsen-Saines K, Guaraldo L, Fuller T, Lopes Moreira ME. A decade later, what have we learned from the Zika epidemic in children with intrauterine exposure? Lancet. 2025;406(10500):295–306.

Article  PubMed  PubMed Central  Google Scholar 

Devakumar D, Bamford A, Ferreira MU, Broad J, Rosch RE, Groce N, et al. Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management. Lancet Infect Dis. 2018;18(1):e1–13.

Article  PubMed  Google Scholar 

Persaud M, Martinez-Lopez A, Buffone C, Porcelli SA, Diaz-Griffero F. Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH. Virology. 2018;518:301–12.

Article  PubMed  PubMed Central  Google Scholar 

Sanami S, Banihashemian SZ, Amirpour S, Alibabaei F, Babaeizad A, Yousefi M, Eslami M. Neuroteratogenic mechanisms of Zika virus (ZIKV) infection: Insights into fetal brain development disruption and congenital Zika syndrome: A systematic review. Mol Aspects Med. 2025;106:101418.

Article  PubMed  Google Scholar 

Chen X, Wang Y, Xu Z, Cheng ML, Ma QQ, Li RT, et al. Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1. Nat Commun. 2023;14(1):1134.

Article  PubMed  PubMed Central  Google Scholar 

Han X, Du J, Li W, Yang S, Sun H, Wang G, Cong H. Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development. Front Cell Infect Microbiol. 2026;16:1754465.

Article  PubMed  PubMed Central  Google Scholar 

Cle M, Desmetz C, Barthelemy J, Martin MF, Constant O, Maarifi G et al. Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier. mBio. 2020;11(4).

Quincozes-Santos A, Bobermin LD, Costa NLF, Thomaz NK, Almeida RRS, Beys-da-Silva WO, et al. The role of glial cells in Zika virus-induced neurodegeneration. Glia. 2023;71(8):1791–803.

Article  PubMed  Google Scholar 

Rubio-Hernandez EI, Comas-Garcia M, Coronado-Ipina MA, Colunga-Saucedo M, Gonzalez Sanchez HM, Castillo CG. Astrocytes derived from neural progenitor cells are susceptible to Zika virus infection. PLoS ONE. 2023;18(3):e0283429.

Article  PubMed  PubMed Central  Google Scholar 

Cranston JS, Tiene SF, Nielsen-Saines K, Vasconcelos Z, Pone MV, Pone S, et al. Association Between Antenatal Exposure to Zika Virus and Anatomical and Neurodevelopmental Abnormalities in Children. JAMA Netw Open. 2020;3(7):e209303.

Article  PubMed  PubMed Central  Google Scholar 

Brasil P, Pereira JP Jr., Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro. N Engl J Med. 2016;375(24):2321–34.

Article  PubMed  PubMed Central  Google Scholar 

Pessoa A, van der Linden V, Yeargin-Allsopp M, Carvalho M, Ribeiro EM, Van Naarden Braun K, et al. Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. Pediatrics. 2018;141(Suppl 2):S167–79.

Article  PubMed  Google Scholar 

Carvalho A, Brites C, Mochida G, Ventura P, Fernandes A, Lage ML, et al. Clinical and neurodevelopmental features in children with cerebral palsy and probable congenital Zika. Brain Dev. 2019;41(7):587–94.

Article  PubMed  Google Scholar 

van der Linden H Jr., Carvalho MD, van der Linden V, Lacerda KM, Pessoa A, Carneiro ML, et al. Epilepsy Profile in Infants with Congenital Zika Virus Infection. N Engl J Med. 2018;379(9):891–2.

Article  PubMed  Google Scholar 

Carvalho M, Ximenes RAA, Montarroyos UR, da Silva PFS, Andrade-Valenca LPA, Eickmann SH, et al. Early epilepsy in children with Zika-related microcephaly in a cohort in Recife, Brazil: Characteristics, electroencephalographic findings, and treatment response. Epilepsia. 2020;61(3):509–18.

Article  PubMed  PubMed Central  Google Scholar 

Blackmon K, Waechter R, Landon B, Noel T, Macpherson C, Donald T, et al. Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure. PLoS Negl Trop Dis. 2020;14(11):e0008874.

Article  PubMed  PubMed Central  Google Scholar 

Maia CQ, Lima WG, Nizer W, Ferreira JMS. Epilepsy in children with Congenital Zika Syndrome: A systematic review and meta-analysis. Epilepsia. 2021;62(5):1193–207.

Article  PubMed  Google Scholar 

Tedde JGG, Cerqueira-Silva T, Carroll O, Rodrigues LC, Teixeira MG, Clemente NS, et al. Prenatal Exposure to Zika Virus and Risk of Epilepsy-Related Hospitalization During Early Childhood. JAMA Pediatr. 2026;180(2):171–8.

Article  PubMed

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