WHO Report on Cancer: setting priorities, investing wisely and providing care for all 2020, World Health Organization.
Stewart, B. W. & Wild, C. P. (2014) World Cancer Report 2014, International Agency for Research on Cancer, Lyon.
Nurgali, K. et al. Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae? Front. Pharmacol. 9, 245 (2018).
Article PubMed PubMed Central Google Scholar
Cancer Research Institute 2020, Cancer vaccines: preventive, therapeutic, personalised.
Zepp, F. Principles of vaccination. Vaccine Design: Methods and Protocols: Volume 1: Vaccines for Human Diseases (S. Thomas), 57–84 (Springer, 2016).
Lin, C. L. & Kao, J. H. Hepatitis B: immunization and impact on natural history and cancer incidence. Gastroenterol. Clin. North Am. 49, 201–214 (2020).
Markowitz, L. E. & Unger, E. R. Human papillomavirus vaccination. N. Engl. J. Med. 388, 1790–1798 (2023).
Article PubMed PubMed Central Google Scholar
Ahrends, T. et al. CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness. Immunity 47, 848–861.e5 (2017).
Article CAS PubMed Google Scholar
Wang, H. & Mooney, D. J. Biomaterial-assisted targeted modulation of immune cells in cancer treatment. Nat. Mater. 17, 761–772 (2018).
Article CAS PubMed Google Scholar
Hollingsworth, R. E. & Jansen, K. Turning the corner on therapeutic cancer vaccines. npj Vaccines. 4, 1–10 (2019).
Barnes, T. A. & Amir, E. HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer. Br. J. Cancer 117, 451–460 (2017).
Article CAS PubMed PubMed Central Google Scholar
Soysal, S. D. et al. Role of the tumor microenvironment in breast cancer. Pathobiology 82, 142–152 (2015).
Article CAS PubMed Google Scholar
Purcell, A. et al. More than one reason to rethink the use of peptides in vaccine design. Nat. Rev. Drug Discov. 6, 404–414 (2007).
Article CAS PubMed Google Scholar
Oyarzun, P. & Kobe, B. Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. Int. J. Immunogenet. 42, 313–321 (2015).
Article CAS PubMed Google Scholar
Slingluff, C. L. Jr The present and future of peptide vaccines for cancer: single or multiple, long or short, alone or in combination? Cancer J. 17, 343–350 (2011).
Article CAS PubMed PubMed Central Google Scholar
Tanaka, Y., et al. TAS0314, a novel multi-epitope long peptide vaccine, showed synergistic antitumor immunity with PD-1/PD-L1 blockade in HLA-A*2402 mice. Sci. Rep. 12, 6082 (2020).
Bijker, M. S. et al. CD8+ CTL priming by exact peptide epitopes in incomplete Freund’s adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity. J. Immunol. 179, 5033–5040 (2007).
Article CAS PubMed Google Scholar
Rabu, C., et al. Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells. Oncoimmunology 8, e1560919 (2019).
Article PubMed PubMed Central Google Scholar
Skwarczynski, M. & Toth, I. Peptide-based synthetic vaccines. Chem. Sci. 7, 842–854 (2016).
Article CAS PubMed Google Scholar
Sidney, J. et al. HLA class I supertypes: a revised and updated classification. BMC Immunol. 9, 1 (2008).
Article PubMed PubMed Central Google Scholar
Liu, J. et al. Recent advances in mRNA vaccine technology. Curr. Opin. Immunol. 65, 14–20 (2020).
Stephens, A.J. et al. Beyond just peptide antigens: the complex world of peptide-based cancer vaccines. Front. Immunol. 12, 696791 (2021).
Article CAS PubMed PubMed Central Google Scholar
Wang, Y.S. et al. mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications. J. Biomed. Sci. 30, 84 (2023).
Article CAS PubMed PubMed Central Google Scholar
Xie, C. et al. The advances of adjuvants in mRNA vaccines. npj Vaccines 8, 162 (2023).
Article PubMed PubMed Central Google Scholar
Rojas, L. A. et al. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature 618, 144–150 (2023).
Article CAS PubMed PubMed Central Google Scholar
Weber, J. S. et al. Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study. Lancet 403, 632–644 (2024).
Article CAS PubMed Google Scholar
Barbier, A. J. et al. The clinical progress of mRNA vaccines and immunotherapies. Nat. Biotechnol. 40, 840–854 (2022).
Article CAS PubMed Google Scholar
Pardi, N. et al. Recent advances in mRNA vaccine technology. Curr. Opin. Immunol. 65, 14–20 (2020).
Article CAS PubMed Google Scholar
Li, Y., et al. mRNA vaccine in cancer therapy: current advance and future outlook. CTM 13, e1384 (2023)
CAS PubMed PubMed Central Google Scholar
Kenoosh, H. A., et al. Recent advances in mRNA-based vaccine for cancer therapy; bench to bedside. Cell Biochem. Funct. 42, e3954 (2024).
Article CAS PubMed Google Scholar
Woldemeskel, B. A., et al. CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses. J. Clin. Investig. 132, e156083 (2022).
Heitmann, J. S. et al. A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature 601, 617–622 (2022).
Article CAS PubMed Google Scholar
Tandler, C. et al. Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults. IJID 139, 69–77 (2024).
Kalita, P. & Tripathi, T. Methodological advances in the design of peptide-based vaccines. Drug Discov. Today 27, 1367–1380 (2022).
Article CAS PubMed Google Scholar
Sckisel, G. D. et al. Out-of-sequence signal 3 paralyses primary CD4+ T-cell-dependent immunity. Immunity 43, 240–250 (2015).
Article CAS PubMed PubMed Central Google Scholar
Fukaya, T. et al. Analysis of DC functions using CD205-DTR knock-in mice. Dendritic Cell Protocols. Methods in Molecular Biology Segura, E. (eds), 291–308 (Springer, 2016).
Geng, J. et al. Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP). PLoS Pathog. 14, e1007171 (2018).
Article PubMed PubMed Central Google Scholar
den Brok, M. H. et al. Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation. Nat. Commun. 7, 13324 (2016).
Ahrends, T. et al. CD4+ T cell help create memory CD8+ T cells with innate and help-independent recall capacities. Nat. Commun. 10, 5531 (2019).
Ferris, S. T. et al. cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity. Nature 584, 624–629 (2020).
Noubade, R. et al. Beyond cDC1: emerging roles of DC crosstalk in cancer immunity. Front. Immunol. 10, 1014 (2019).
Comments (0)