Tracing the pathways: how inflammatory cytokines and blood metabolites drive intervertebral disc degeneration

Knezevic NN, Candido KD, Vlaeyen JWS, Van Zundert J, Cohen SP (2021) Low back pain. The Lancet 398:78–92. https://doi.org/10.1016/s0140-6736(21)00733-9

Article  Google Scholar 

Li Z, Chen X, Xu D, Li S, Chan MTV, Wu WKK (2019) Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. https://doi.org/10.1111/cpr.12704

Article  PubMed  PubMed Central  Google Scholar 

Wang F, Cai F, Shi R, Wang XH, Wu XT (2016) Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthr Cartil 24:398–408. https://doi.org/10.1016/j.joca.2015.09.019

Article  CAS  Google Scholar 

Risbud MV, Shapiro IM (2014) Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 10:44–56. https://doi.org/10.1038/nrrheum.2013.160

Article  CAS  PubMed  Google Scholar 

Luo J, Yang Y, Wang X, Chang X, Fu S (2022) Role of pyroptosis in intervertebral disc degeneration and its therapeutic implications. Biomolecules. https://doi.org/10.3390/biom12121804

Article  PubMed  PubMed Central  Google Scholar 

Stirling A, Worthington T, Rafiq M, Lambert PA, Elliott TSJ (2001) Association between sciatica and Propionibacterium acnes. The Lancet 357:2024–2025. https://doi.org/10.1016/s0140-6736(00)05109-6

Article  CAS  Google Scholar 

Wu X, Liu C, Yang S, Shen N, Wang Y, Zhu Y, Guo Z, Yang S-y, Xing D, Li H, Guo Z, Chen B, Xiang H, Gebicki J (2021) Glycine-serine-threonine metabolic axis delays intervertebral disc degeneration through antioxidant effects: an imaging and metabonomics study. Oxid Med Cell Longev 2021:1–33. https://doi.org/10.1155/2021/5579736

Article  CAS  Google Scholar 

Zhang Y, Liu L, Qi Y, Lou J, Chen Y, Liu C, Li H, Chang X, Hu Z, Li Y, Zhang Y, Feng C, Zhou Y, Zhai Y, Li C (2024) Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt. Cell Mol Life Sci. https://doi.org/10.1007/s00018-023-05094-y

Article  PubMed  PubMed Central  Google Scholar 

Sekula P, Del Greco MF, Pattaro C, Köttgen A (2016) Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol 27:3253–3265. https://doi.org/10.1681/asn.2016010098

Article  PubMed  PubMed Central  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, Langenberg C, Golub RM, Loder EW, Gallo V, Tybjaerg-Hansen A, Davey Smith G, Egger M, Richards JB (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomization. Jama. https://doi.org/10.1001/jama.2021.18236

Article  PubMed  Google Scholar 

Ahola-Olli AV, Wurtz P, Havulinna AS, Aalto K, Pitkanen N, Lehtimaki T, Kahonen M, Lyytikainen LP, Raitoharju E, Seppala I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT (2017) Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am J Hum Genet 100:40–50. https://doi.org/10.1016/j.ajhg.2016.11.007

Article  CAS  PubMed  Google Scholar 

Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH, Yoshiji S, Willett JDS, Su CY, Raina P, Greenwood CMT, Farjoun Y, Forgetta V, Langenberg C, Zhou S, Ohlsson C, Richards JB (2023) Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nat Genet 55:44–53. https://doi.org/10.1038/s41588-022-01270-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Rämö J, Kiiskinen T, Heyne HO, Veerapen K, Rüeger S, Lemmelä S, Zhou W, Ruotsalainen S, Pärn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setälä K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen C-Y, Dada OA, Ding Z, Ehm MG, Eklund K, Färkkilä M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman ÅK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen J-N, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kähönen M, Kajanne R, Kallio L, Kälviäinen R, Kaprio J, Kerimov N, Kettunen J, Kilpeläinen E, Kilpi T, Klinger K, Kosma V-M, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Mägi R, Mäkelä J, Mäkitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T, Mozaffari SV, Niemi MEK, Niemi M et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508–518. https://doi.org/10.1038/s41586-022-05473-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40:755–764. https://doi.org/10.1093/ije/dyr036

Article  PubMed  Google Scholar 

Sanderson E (2021) Multivariable Mendelian randomization and mediation. Cold Spring Harbor Perspect Med. https://doi.org/10.1101/cshperspect.a038984

Article  Google Scholar 

Burgess S, Daniel RM, Butterworth AS, Thompson SG (2014) Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways. Int J Epidemiol 44:484–495. https://doi.org/10.1093/ije/dyu176

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG (2015) Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol 181:251–260. https://doi.org/10.1093/aje/kwu283

Article  PubMed  PubMed Central  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, Timpson NJ, Higgins JPT, Dimou N, Langenberg C, Loder EW, Golub RM, Egger M, Davey Smith G, Richards JB (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ. https://doi.org/10.1136/bmj.n2233

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693–698. https://doi.org/10.1038/s41588-018-0099-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440–9445. https://doi.org/10.1073/pnas.1530509100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kepler CK, Markova DZ, Dibra F, Yadia S, Vaccaro AR, Risbud M, Albert TJ, Anderson DG (2013) Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs. Spine 38:873–880. https://doi.org/10.1097/BRS.Ob013e318285ae08

Article  PubMed  Google Scholar 

Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L, Bullock R, Isaacs RE, Brown C, Richardson WJ (2010) Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum 62:1974–1982. https://doi.org/10.1002/art.27444

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou X, Shen Y, Sun M, Zhang B, Dai J, Chen D, Liu Z (2022) Effect of regulating macrophage polarization phenotype on intervertebral disc degeneration. Immun Inflamm Dis. https://doi.org/10.1002/iid3.714

Article  PubMed  PubMed Central  Google Scholar 

Chu C-Q, Wittmer S, Dalton DK (2000) Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 192:123–128. https://doi.org/10.1084/jem.192.1.123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karli P, Martle V, Bossens K, Summerfield A, Doherr MG, Turner P, Vandevelde M, Forterre F, Henke D (2014) Dominance of chemokine ligand 2 and matrix metalloproteinase-2 and -9 and suppression of pro-inflammatory cytokines in the epidural compartment after intervertebral disc extrusion in a canine model. Spine J 14:2976–2984. https://doi.org/10.1016/j.spinee.2014.05.021

Article  PubMed 

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