Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis

Schultz MJ, van Meenen DM, Bos LD. COVID-19-related acute respiratory distress syndrome: lessons learned during the pandemic. Lancet Respir Med. 2022;10:1108–10.

Article  PubMed  PubMed Central  Google Scholar 

O’Reilly S. Pulmonary fibrosis in COVID-19: mechanisms, consequences and targets. QJM. 2023;116:750–4.

Article  PubMed  Google Scholar 

Bos LDJ, Ware LB. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022;400:1145–56.

Article  PubMed  Google Scholar 

Koudstaal T, Funke-Chambour M, Kreuter M, Molyneaux PL, Wijsenbeek MS. Pulmonary fibrosis: from pathogenesis to clinical decision-making. Trends Mol Med. 2023;29:1076–87.

Article  CAS  PubMed  Google Scholar 

Silva MJA, Ribeiro LR, Gouveia MIM, Marcelino BDR, Santos CSD, Lima KVB, Lima L. Hyperinflammatory response in COVID-19: a systematic review. Viruses. 2023;15:553.

Burn GL, Foti A, Marsman G, Patel DF, Zychlinsky A. The neutrophil. Immunity. 2021;54:1377–91.

Article  CAS  PubMed  Google Scholar 

Galani IE, Andreakos E. Neutrophils in viral infections: current concepts and caveats. J Leukoc Biol. 2015;98:557–64.

Article  CAS  PubMed  Google Scholar 

Mutua V, Gershwin LJ. A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics. Clin Rev Allergy Immunol. 2021;61:194–211.

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Dominguez-Diaz C, Varela-Trinidad GU, Munoz-Sanchez G, Solorzano-Castanedo K, Avila-Arrezola KE, Iniguez-Gutierrez L, Delgado-Rizo V, Fafutis-Morris M. To trap a pathogen: neutrophil extracellular traps and their role in mucosal epithelial and skin diseases. Cells. 2021;10:1469.

Liew PX, Kubes P. The neutrophil’s role during health and disease. Physiol Rev. 2019;99:1223–48.

Article  CAS  PubMed  Google Scholar 

Herrero-Cervera A, Soehnlein O, Kenne E. Neutrophils in chronic inflammatory diseases. Cell Mol Immunol. 2022;19:177–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prozan L, Shusterman E, Ablin J, Mitelpunkt A, Weiss-Meilik A, Adler A, Choshen G, Kehat O. Prognostic value of neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection. Sci Rep. 2021;11:21519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hazeldine J, Lord JM. Neutrophils and COVID-19: active participants and rational therapeutic targets. Front Immunol. 2021;12:680134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, Rafailidis P, Ntinopoulou M, Sertaridou E, Tsironidou V, Tsigalou C, et al. Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. J Clin Invest. 2020;130:6151–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pastorek M, Dubrava M, Celec P. On the origin of neutrophil extracellular traps in COVID-19. Front Immunol. 2022;13:821007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Zhang K, Zhang Y, Gu Z, Huang C. Neutrophils in COVID-19: recent insights and advances. Virol J. 2023;20:169.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, et al. Patients with COVID-19: in the dark-NETs of neutrophils. Cell Death Differ. 2021;28:3125–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schulte-Schrepping J, Reusch N, Paclik D, Bassler K, Schlickeiser S, Zhang B, Kramer B, Krammer T, Brumhard S, Bonaguro L, et al. Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell. 2020;182:1419–40.e23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aschenbrenner AC, Mouktaroudi M, Kramer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Bassler K, et al. Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med. 2021;13:7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, et al. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Adv. 2021;5:1164–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, et al. Circulating markers of angiogenesis and endotheliopathy in COVID-19. Pulm Circ. 2020;10:2045894020966547.

Article  PubMed  PubMed Central  Google Scholar 

Synolaki E, Papadopoulos V, Divolis G, Tsahouridou O, Gavriilidis E, Loli G, Gavriil A, Tsigalou C, Tziolos NR, Sertaridou E, et al. The Activin/Follistatin axis is severely deregulated in COVID-19 and independently associated with in-hospital mortality. J Infect Dis. 2021;223:1544–54.

Article  CAS  PubMed  Google Scholar 

Mei Q, Liu Z, Zuo H, Yang Z, Qu J. Idiopathic pulmonary fibrosis: an update on pathogenesis. Front Pharmacol. 2021;12:797292.

Article  CAS  PubMed  Google Scholar 

Podolanczuk AJ, Thomson CC, Remy-Jardin M, Richeldi L, Martinez FJ, Kolb M, Raghu G. Idiopathic pulmonary fibrosis: state of the art for 2023. Eur Respir J. 2023;61:2200957.

Obayashi Y, Yamadori I, Fujita J, Yoshinouchi T, Ueda N, Takahara J. The role of neutrophils in the pathogenesis of idiopathic pulmonary fibrosis. Chest. 1997;112:1338–43.

Article  CAS  PubMed  Google Scholar 

Achaiah A, Rathnapala A, Pereira A, Bothwell H, Dwivedi K, Barker R, Iotchkova V, Benamore R, Hoyles RK, Ho LP. Neutrophil lymphocyte ratio as an indicator for disease progression in idiopathic pulmonary fibrosis. BMJ Open Respir Res. 2022;9:e001202.

Huang E, Peng N, Xiao F, Hu D, Wang X, Lu L. The roles of immune cells in the pathogenesis of fibrosis. Int J Mol Sci. 2020;21:5203.

Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM. Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. J Leukoc Biol. 2015;98:143–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2018;198:e44–68.

Article  PubMed  Google Scholar 

Gavriilidis E, Divolis G, Natsi AM, Kafalis N, Kogias D, Antoniadou C, Synolaki E, Pavlos E, Koutsi MA, Didaskalou S, et al. Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn’s disease through IFNalpha pathway. Front Immunol. 2024;15:1447608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitroulis I, Chrysanthopoulou A, Divolis G, Ioannidis C, Ntinopoulou M, Tasis A, Konstantinidis T, Antoniadou C, Soteriou N, Lallas G, et al. A gene expression map of host immune response in human brucellosis. Front Immunol. 2022;13:951232.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Divolis G, Stavropoulos A, Manioudaki M, Apostolidou A, Doulou A, Gavriil A, Dafnis I, Chroni A, Mummery C, Xilouri M, Sideras P. Activation of both transforming growth factor-beta and bone morphogenetic protein signalling pathways upon traumatic brain injury restrains pro-inflammatory and boosts tissue reparatory responses of reactive astrocytes and microglia. Brain Commun. 2019;1:fcz028.

Article  PubMed 

Comments (0)

No login
gif