Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, Matsuoka N, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Nakao K (2000) Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 105:1243–1252
Article CAS PubMed PubMed Central Google Scholar
American P, Association, [APA] (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th Edn. American Psychiatric Publishing, Arlington, VA
Antel J, Tan S, Grabler M, Ludwig C, Lohkemper D, Brandenburg T, Barth N, Hinney A, Libuda L, Remy M, Milos G, Hebebrand J (2022) Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism. Eur Child Adolesc Psychiatry 31:1573–1579
Arnold S, Wiese A, Zaid S, Correll CU, Jaite C (2022) Lifetime prevalence and clinical correlates of nonsuicidal self-injury in youth inpatients with eating disorders: a retrospective chart review. Child Adolesc Psychiatry Ment Health 16:17
Article PubMed PubMed Central Google Scholar
Ballauff A, Ziegler A, Emons G, Sturm G, Blum WF, Remschmidt H, Hebebrand J (1999) Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain. Mol Psychiatry 4:71–75
Article CAS PubMed Google Scholar
Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W (1997) Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 82:2904–2910
Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P (2018) Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy. Endocrine 60:479–489
Article CAS PubMed PubMed Central Google Scholar
Burns J, Shank C, Ganigara M, Saldanha N, Dhar A (2021) Cardiac complications of malnutrition in adolescent patients: A narrative review of contemporary literature. Ann Pediatr Cardiol 14:501–506
Button KS, Kounali D, Thomas L, Wiles NJ, Peters TJ, Welton NJ, Ades AE, Lewis G (2015) Minimal clinically important difference on the Beck depression Inventory–II according to the patient’s perspective. Psychol Med 45:3269–3279
Article CAS PubMed PubMed Central Google Scholar
Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG (2001) Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension 37:936–942
Article CAS PubMed Google Scholar
Drakes DH, Fawcett EJ, Rose JP, Carter-Major JC, Fawcett JM (2021) Comorbid obsessive-compulsive disorder in individuals with eating disorders: an epidemiological meta-analysis. J Psychiatr Res 141:176–191
EMA (2018) MYALEPTA-SUMMARY OF PRODUCT CHARACTERISTICS. In: https://www.ema.europa.eu/en/documents/product-information/myalepta-epar-product-information_en.pdf
Exner C, Hebebrand J, Remschmidt H, Wewetzer C, Ziegler A, Herpertz S, Schweiger U, Blum WF, Preibisch G, Heldmaier G, Klingenspor M (2000) Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry 5:476–481
Article CAS PubMed Google Scholar
FDA (2014) E.A. RESEARCH. In: Administration FD (ed) SUMMARY REVIEW for regulatory action; myalept; application number 125390Orig1s000. ed)FDA, Silver Spring, MD
Focker M, Timmesfeld N, Scherag S, Buhren K, Langkamp M, Dempfle A, Sheridan EM, de Zwaan M, Fleischhaker C, Herzog W, Egberts K, Zipfel S, Herpertz-Dahlmann B, Hebebrand J (2011) Screening for anorexia nervosa via measurement of serum leptin levels. J Neural Transm (Vienna) 118:571–578
Article CAS PubMed Google Scholar
Föcker M, Antel J, Grasemann C, Führer D, Timmesfeld N, Öztürk D, Peters T, Hinney A, Hebebrand J, Libuda L (2018) Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol. BMC Psychiatry 18:57
Article PubMed PubMed Central Google Scholar
Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311–1314
Article CAS PubMed Google Scholar
Gradl-Dietsch G, Bell R, Tschöpe F, Milos G, Wabitsch M, Antel J, Hebebrand J (2022) Rapid emergence of appetite and hunger resulting in weight gain and improvement of eating disorder symptomatology during and after short-term off-label metreleptin treatment of a patient with anorexia nervosa; in revision. Obesity Facts
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C (2021) Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metab 33:1155–1170e1110
Article CAS PubMed PubMed Central Google Scholar
Haque Z, Lakho GR, Nafees M, Shahid KU, Mazahir I (2006) Serum leptin levels correlation with high blood pressure in adult females. J Coll Physicians Surg Pak 16:450–454
Hautzinger M, Keller F, Kühner C (2006) BDI-II. Beck depressions inventar revision-Manual. Harcourt Test Services, Frankfurt, Germany
Hebebrand J, Bulik CM (2011) Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal. Int J Eat Disord 44:665–678
Hebebrand J, van der Heyden J, Devos R, Kopp W, Herpertz S, Remschmidt H, Herzog W (1995) Plasma concentrations of obese protein in anorexia nervosa. Lancet 346:1624–1625
Article CAS PubMed Google Scholar
Hebebrand J, Blum WF, Barth N, Coners H, Englaro P, Juul A, Ziegler A, Warnke A, Rascher W, Remschmidt H (1997) Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration. Mol Psychiatry 2:330–334
Article CAS PubMed Google Scholar
Hebebrand J, Milos G, Wabitsch M, Teufel M, Fuhrer D, Buhlmeier J, Libuda L, Ludwig C, Antel J (2019) Clinical trials required to assess potential benefits and side effects of treatment of patients with anorexia nervosa with Recombinant human leptin. Front Psychol 10:769
Article PubMed PubMed Central Google Scholar
Hebebrand J, Hildebrandt T, Schlögl H, Seitz J, Denecke S, Vieira D, Gradl-Dietsch G, Peters T, Antel J, Lau D, Fulton S (2022) The role of hypoleptinemia in the psychological and behavioral adaptation to starvation: implications for anorexia nervosa. Neurosci Biobehav Rev 141:104807
Hebebrand J, Hinney A, Antel J (2023) Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa? Nat Rev Endocrinol 19:435–436
Hebebrand J, Antel J, von Piechowski L, Kiewert C, Stüve B, Gradl-Dietsch G (2023) Case report: rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes. Front Psychiatry 14:1267495
Article PubMed PubMed Central Google Scholar
Hebebrand J, Plieger M, Milos G, Peters T, Hinney A, Antel J (2024) Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations. Eur Eat Disord Rev 32:557–574
Hebebrand J, Antel J, Peters T (2024) Case report: clinical improvements observed in first off-label metreleptin treatment of a patient with atypical anorexia nervosa. Eur Child Adolesc Psychiatry 33:2267–2272
Hebebrand J, Gradl-Dietsch G, Peters T, Correll CU, Haas V (2024) The diagnosis and treatment of anorexia nervosa in childhood and adolescence. Dtsch Arztebl Int 121:164–174
PubMed PubMed Central Google Scholar
Keller F, Grieb J, Ernst M, Sprober N, Fegert JM, Kolch M (2011) [Children’s depression rating Scale-Revised (CDRS-R): development of a German version and psychometric properties in a clinical sample]. Z Kinder Jugendpsychiatr Psychother 39:179–185
Keys A, Brozek J, Henschel A, Mickelsen O, Taylor HL (1950) The biology of human starvation (2 volumes). University of Minnesota Press
Kopp W, Blum WF, von Prittwitz S, Ziegler A, Lubbert H, Emons G, Herzog W, Herpertz S, Deter HC, Remschmidt H, Hebebrand J (1997) Low leptin levels predict amenorrhea in underweight and eating disordered females. Mol Psychiatry 2:335–340
Article CAS PubMed Google Scholar
Kounali D
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