Dalsgaard S, Thorsteinsson E, Trabjerg BB, Schullehner J, Plana-Ripoll O, Brikell I et al (2020) Incidence rates and cumulative incidences of the full spectrum of diagnosed mental disorders in childhood and adolescence. JAMA Psychiat 77(2):155
Keyes KM, Platt JM (2024) Annual research review: sex, gender, and internalizing conditions among adolescents in the 21st century – trends, causes, consequences. Child Psychol Psychiatry 65(4):384–407
McElroy E, Shevlin M, Murphy J, McBride O (2018) Co-occurring internalizing and externalizing psychopathology in childhood and adolescence: a network approach. Eur Child Adolesc Psychiatry 27(11):1449–1457
Menon V (2011) Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn Sci 15(10):483–506
Xia CH, Ma Z, Ciric R, Gu S, Betzel RF, Kaczkurkin AN et al (2018) Linked dimensions of psychopathology and connectivity in functional brain networks. Nat Commun 9(1):3003
Article PubMed PubMed Central Google Scholar
MacSweeney N, Toenders YJ, Tamnes CK (2025) Neuroimaging insights into adolescent depression risk and development. Nat. Mental Health 3:772–779. https://doi.org/10.1038/s44220-025-00453-z
Lynch CJ, Gunning FM, Liston C (2020) Causes and consequences of diagnostic heterogeneity in depression: paths to discovering novel biological depression subtypes. Biol Psychiatry 88(1):83–94
Article CAS PubMed Google Scholar
Rice F, Riglin L, Lomax T, Souter E, Potter R, Smith DJ et al (2019) Adolescent and adult differences in major depression symptom profiles. J Affect Disord 243:175–181
Article CAS PubMed Google Scholar
Feczko E, Miranda-Dominguez O, Marr M, Graham AM, Nigg JT, Fair DA (2019) The heterogeneity problem: approaches to identify psychiatric subtypes. Trends Cogn Sci 23(7):584–601
Article PubMed PubMed Central Google Scholar
Segal A, Tiego J, Parkes L, Holmes AJ, Marquand AF, Fornito A (2025) Embracing variability in the search for biological mechanisms of psychiatric illness. Trends Cogn Sci 29(1):85–99
Borsboom D (2017) A network theory of mental disorders. World Psychiatry 16(1):5–13
Article PubMed PubMed Central Google Scholar
Blanken TF, Bathelt J, Deserno MK, Voge L, Borsboom D, Douw L (2021) Connecting brain and behavior in clinical neuroscience: a network approach. Neurosci Biobehav Rev 1(130):81–90
Park HJ, Friston K (2013) Structural and functional brain networks: from connections to cognition. Science 342(6158):1238411
Sporns O (2013) Structure and function of complex brain networks. Dialogues Clin Neurosci 15(3):247–262
Article PubMed PubMed Central Google Scholar
Gordon EM, Laumann TO, Adeyemo B, Huckins JF, Kelley WM, Petersen SE (2016) Generation and evaluation of a cortical area parcellation from resting-state correlations. Cereb Cortex 26(1):288–303
Power JD, Cohen AL, Nelson SM, Wig GS, Barnes KA, Church JA et al (2011) Functional network organization of the human brain. Neuron 72(4):665–678
Article CAS PubMed PubMed Central Google Scholar
Ho TC, Connolly CG, HenjeBlom E, LeWinn KZ, Strigo IA, Paulus MP et al (2015) Emotion-dependent functional connectivity of the default mode network in adolescent depression. Biol Psychiatry 78(9):635–646
Kaiser RH, Andrews-Hanna JR, Wager TD, Pizzagalli DA (2015) Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiat 72(6):603
Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H et al (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27(9):2349–2356
Article CAS PubMed PubMed Central Google Scholar
Sridharan D, Levitin DJ, Menon V (2008) A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A 105(34):12569–12574
Article CAS PubMed PubMed Central Google Scholar
Lynch CJ, Elbau IG, Ng T, Ayaz A, Zhu S, Wolk D, Liston C (2024) Frontostriatal salience network expansion in individuals in depression. Nature 633(8030):624–633. https://doi.org/10.1038/s41586-024-07805-2
Article CAS PubMed PubMed Central Google Scholar
Geng H, Li X, Chen J, Li X, Gu R (2016) Decreased intra- and inter-salience network functional connectivity is related to trait anxiety in adolescents. Front Behav Neurosci [Internet]. [cited 2024 Sep 26];9. Available from: http://journal.frontiersin.org/Article/10.3389/fnbeh.2015.00350/abstract
Markett S, Montag C, Melchers M, Weber B, Reuter M (2016) Anxious personality and functional efficiency of the insular-opercular network: a graph-analytic approach to resting-state fMRI. Cogn Affect Behav Neurosci 16(6):1039–1049
Xu J, Van Dam NT, Feng C, Luo Y, Ai H, Gu R et al (2019) Anxious brain networks: a coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety. Neurosci Biobehav Rev 96:21–30
Satterthwaite TD, Wolf DH, Ruparel K, Erus G, Elliott MA, Eickhoff SB et al (2013) Heterogeneous impact of motion on fundamental patterns of developmental changes in functional connectivity during youth. Neuroimage 83:45–57
Article PubMed PubMed Central Google Scholar
Bertocci MA, Afriyie-Agyemang Y, Rozovsky R, Iyengar S, Stiffler R, Aslam HA et al (2023) Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples. Mol Psychiatry 28(3):1046–1056
Sacchet MD, Ho TC, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK et al (2016) Large-scale hypoconnectivity between resting-state functional networks in unmedicated adolescent major depressive disorder. Neuropsychopharmacol 41(12):2951–2960
Fried EI, Van Borkulo CD, Cramer AOJ, Boschloo L, Schoevers RA, Borsboom D (2017) Mental disorders as networks of problems: a review of recent insights. Soc Psychiatry Psychiatr Epidemiol 52(1):1–10
Fornito A, Zalesky A, Breakspear M (2015) The connectomics of brain disorders. Nat Rev Neurosci 16(3):159–172
Article CAS PubMed Google Scholar
Insel TR, Cuthbert BN (2015) Brain disorders? Precisely. Science 348(6234):499–500
Article CAS PubMed Google Scholar
Borsboom D, Deserno MK, Rhemtulla M, Epskamp S, Fried EI, McNally RJ et al (2021) Network analysis of multivariate data in psychological science. Nature Reviews Methods Primers 1(1):58
Bassett DS, Xia CH, Satterthwaite TD (2018) Understanding the emergence of neuropsychiatric disorders with network neuroscience. Biol Psychiatry: Cogn Neurosci Neuroimaging 3(9):742–753
PubMed PubMed Central Google Scholar
Beard C, Millner AJ, Forgeard MJC, Fried EI, Hsu KJ, Treadway MT et al (2016) Network analysis of depression and anxiety symptom relationships in a psychiatric sample. Psychol Med 46(16):3359–3369
Article CAS PubMed PubMed Central Google Scholar
Aksnes ER, Birkeland MS, Ebrahimi OV, Bekkhus M, Ferschmann L, Beck D, Tamnes CK (2025) Developme ntal dynamics of symptoms of emotional problems in childhood and adolescence: A longitudinal network analysis. Jcpp Advances e70079. https://doi.org/10.1002/jcv2.70079
Funkhouser CJ, Chacko AA, Correa KA, Kaiser AJE, Shankman SA (2021) Unique longitudinal relationships between symptoms of psychopathology in youth: a cross‐lagged panel network analysis in the ABCD
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