Association of left atrial strain and fibrin clot properties in patients with heart failure and severe mitral regurgitation undergoing transcatheter edge-to-edge repair

Karaban K, Słupik D, Reda A, Gajewska M, Rolek B, Borovac JA et al (2024) Coagulation disorders and thrombotic complications in heart failure with preserved ejection fraction. Curr Probl Cardiol 49:102127

Article  PubMed  Google Scholar 

Siniarski A, Gąsecka A, Borovac JA, Papakonstantinou PE, Bongiovanni D, Ehrlinder H et al (2023) Blood coagulation disorders in heart failure: from basic science to clinical perspectives. J Card Fail 29:517–526

Article  PubMed  Google Scholar 

Lin AY, Dinatolo E, Metra M, Sbolli M, Dasseni N, Butler J et al (2021) Thromboembolism in heart failure patients in sinus rhythm. JACC Heart Fail 9:243–253

Article  CAS  PubMed  Google Scholar 

Mebazaa A, Spiro TE, Büller HR, Haskell L, Hu D, Hull R et al (2014) Predicting the risk of venous thromboembolism in patients hospitalized with heart failure. Circulation 130:410–418

Article  CAS  PubMed  Google Scholar 

Fanola CL, Norby FL, Shah AM, Chang PP, Lutsey PL, Rosamond WD et al (2020) Incident heart failure and long-term risk for venous thromboembolism. J Am Coll Cardiol 75:148–158

Article  PubMed  PubMed Central  Google Scholar 

Palka I, Nessler J, Nessler B, Piwowarska W, Tracz W, Undas A (2010) Altered fibrin clot properties in patients with chronic heart failure and sinus rhythm: a novel prothrombotic mechanism. Heart 96:1114–1118

Article  CAS  PubMed  Google Scholar 

Goldhaber SZ (2020) Venous thromboembolism in heart failure patients. J Am Coll Cardiol 75:159–162

Article  PubMed  Google Scholar 

Goyal A, Aggarwal P, Shrivastava A, Pandit BN, Mukhopadhyay S, Yusuf J et al Effect of Mitral Regurgitation on Systemic Coagulation Activity in Rheumatic Heart Disease as Assessed by D-dimer Levels. Cureus [Internet]. 2021 [cited 2025 Jun 8]; Available from: https://www.cureus.com/articles/69765-effect-of-mitral-regurgitation-on-systemic-coagulation-activity-in-rheumatic-heart-disease-as-assessed-by-d-dimer-levels

Okhota S, Melnikov I, Avtaeva Y, Kozlov S, Gabbasov Z (2020) Shear stress-induced activation of von Willebrand factor and cardiovascular pathology. Int J Mol Sci 21:7804

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kupczyńska K, Mandoli GE, Cameli M, Kasprzak JD (2021) Left atrial strain — a current clinical perspective. Kardiol Pol 79:955–964

Article  PubMed  Google Scholar 

Sugimoto T, Bandera F, Generati G, Alfonzetti E, Barletta M, Losito M et al (2020) Left atrial dynamics during exercise in mitral regurgitation of primary and secondary origin. JACC Cardiovasc Imaging 13:25–40

Article  PubMed  Google Scholar 

Mandoli GE, Pastore MC, Benfari G, Bisleri G, Maccherini M, Lisi G et al (2021) Left atrial strain as a pre-operative prognostic marker for patients with severe mitral regurgitation. Int J Cardiol 324:139–145

Article  PubMed  Google Scholar 

Siniarski A, Baker SR, Stępień K, Woźniak A, Ariëns R, Gajos G Left atrium size and volume is associated with fibrin clot ultrastructure in patients with acute myocardial infarction. Pol Arch Intern Med [Internet]. 2023 [cited 2024 Mar 4]; Available from: https://www.mp.pl/paim/issue/article/16625

Pagnesi M, Moroni F, Beneduce A, Giannini F, Colombo A, Weisz G et al (2019) Thrombotic risk and antithrombotic strategies after transcatheter mitral valve replacement. JACC Cardiovasc Interv 12(23):2388–2401

Article  PubMed  Google Scholar 

Vyff F, Johansen ND, Olsen FJ, Duus LS, Lindberg S, Fritz-Hansen T et al (2023) Left atrial reservoir strain predicts ischaemic stroke after coronary artery bypass grafting independent of postoperative atrial fibrillation. Eur Heart J Open 3:oead045

Article  PubMed  PubMed Central  Google Scholar 

Vera A, Cecconi A, Ximénez-Carrillo Á, Ramos C, Martínez-Vives P, Lopez-Melgar B et al (2024) Left atrial strain predicts stroke recurrence and death in patients with cryptogenic stroke. Am J Cardiol 210:51–57

Article  PubMed  Google Scholar 

Park J, Hwang I, Park JJ, Park J, Cho G (2021) Left atrial strain to predict stroke in patients with acute heart failure and sinus rhythm. J Am Heart Assoc 10:e020414

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yashiro Y, Arimoto T, Hashimoto N, Tamura H, Iwayama T, Ishigaki D et al (2014) Predictors of left atrial coagulation activity among paroxysmal atrial fibrillation patients. Circ J 79:61–69

Article  PubMed  Google Scholar 

Matusik PT, Matusik PS, Kornacewicz-Jach Z, Małecka B, Ząbek A, Undas A (2017) Elevated NT-proBNP is associated with unfavorably altered plasma fibrin clot properties in atrial fibrillation. Int J Cardiol 243:244–250

Article  PubMed  Google Scholar 

Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T et al (2018) Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry task force to standardize deformation imaging. Eur Heart J 19:591–600

Google Scholar 

Ząbczyk M, Undas A (2017) Plasma fibrin clot structure and thromboembolism: clinical implications. Pol Arch Intern Med 127:873–881

Article  PubMed  Google Scholar 

Siudut J, Grela M, Wypasek E, Plens K, Undas A (2016) Reduced plasma fibrin clot permeability and susceptibility to lysis are associated with increased risk of postthrombotic syndrome. J Thromb Haemost 14:784–793

Article  CAS  PubMed  Google Scholar 

Ząbczyk M (2025) Incredible fibrin(ogen): from basicmechanisms to clinical implications. Prz Lek Jagiellonian Med Rev. 77:17945. https://doi.org/10.20452/jmr.2025.17945

Natorska J, Corral J, De La Morena-Barrio ME, Bravo-Pérez C, Bagoly Z, Bereczky Z et al (2023) Antithrombin deficiency is associated with prothrombotic plasma fibrin clot phenotype. Thromb Haemost 123:880–891

Article  PubMed  PubMed Central  Google Scholar 

Scisło P, Rdzanek A, Pietrasik A, Kochman J, Opolski G (2021) The function of the heart after successful transcatheter mitral valve repair due to severe functional regurgitation. Pol Arch Intern Med [Internet]. [cited 2024 Jul 28]; Available from: https://www.mp.pl/paim/issue/article/16000

Antithrombotic medications and their impact on fibrin clot structure and function J Physiol Pharmacol [Internet]. 2018 [cited 2024 Nov 21]; Available from: https://doi.org/10.26402/jpp.2018.4.02

Stępień K, Ząbczyk M, Kopytek M, Natorska J, Zalewski J, Undas A (2023) Reduced fibrin clot permeability on admission and elevated E-selectin at 3 months as novel risk factors of residual pulmonary vascular obstruction in patients with acute pulmonary embolism. J Thromb Thrombolysis 57:248–259

Article  PubMed  PubMed Central  Google Scholar 

Kupis RW, Goldman-Mazur S, Polak M, Ząbczyk M, Undas A (2019) Faster fibrin clot degradation characterizes patients with central pulmonary embolism at a low risk of recurrent peripheral embolism. Sci Rep 9:72

Article  PubMed  PubMed Central  Google Scholar 

Hadjadj S, Beaudoin J, Beaupré F, Gravel C, Marsit O, Pouliot S et al (2025) Evolution of coagulation and platelet activation markers after transcatheter edge-to-edge mitral valve repair. J Clin Med 14:831

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Yang Y, Jia L, Su J, Xiao A, Lin X (2023) Anticoagulation therapy and clinical outcomes following transcatheter mitral valve repair for patients with mitral regurgitation: A meta-analysis. Clin Cardiol 46:598–606

Article  PubMed  PubMed Central  Google Scholar 

Mannina C, Ito K, Jin Z, Yoshida Y, Matsumoto K, Shames S et al (2023) Association of left atrial strain with ischemic stroke risk in older adults. JAMA Cardiol 8:317

Article  PubMed  PubMed Central  Google Scholar 

Kupczynska K, Miskowiec D, Michalski BW, Wejner-Mik P, Lipiec P, Kasprzak JD (2022) Speckle tracking-derived left atrial strain rate – undervalued and useful predictor of adverse events. Eur Heart J 43:ehac544067

Article  Google Scholar 

Scalia IG, Farina JM, Wraith R, Brown L, Abbas MT, Pereyra M et al (2024) Association between echocardiographic velocity time integral ratio of mitral valve and left ventricular outflow tract and clinical outcomes post transcatheter edge-to-edge mitral valve repair. Heliyon 10:e32378

Article  PubMed  PubMed Central  Google Scholar 

Qureshi A, Lip GYH, Nordsletten DA, Williams SE, Aslanidi O, De Vecchi A (2023) Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke. Front Cardiovasc Med 9:1074562

Article  PubMed  PubMed Central  Google Scholar 

Alkarithi G, Duval C, Shi Y, Macrae FL, Ariëns RAS (2021) Thrombus structural composition in cardiovascular disease. Arterioscler Thromb Vasc Biol 41:2370–2383

Article  CAS  PubMed  PubMed Central 

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