Trends in pulmonary embolism mortality among older adults with lung cancer in the united States, 1999–2020

Barco S, Valerio L, Gallo A, Turatti G, Mahmoudpour SH, Ageno W et al (2021) Global reporting of pulmonary embolism–related deaths in the World Health Organization mortality database: vital registration data from 123 countries. Res Pract Thromb Haemost 5:e12520. https://doi.org/10.1002/rth2.12520

Article  PubMed  PubMed Central  Google Scholar 

Freund Y, Cohen-Aubart F, Bloom B (2022) Acute pulmonary embolism: a review. JAMA 328:1336–1345. https://doi.org/10.1001/jama.2022.16815

Article  CAS  PubMed  Google Scholar 

CDC. Data and Statistics on Venous Thromboembolism (2025) https://www.cdc.gov/blood-clots/data-research/facts-stats/index.html (accessed September 8, 2025)

Barco S, Valerio L, Ageno W, Cohen AT, Goldhaber SZ, Hunt BJ et al (2021) Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000-18: an analysis of the WHO mortality database and of the CDC multiple cause of death database. Lancet Respir Med 9:33–42. https://doi.org/10.1016/S2213-2600(20)30417-3

Article  PubMed  Google Scholar 

Barco S, Mahmoudpour SH, Valerio L, Klok FA, Münzel T, Middeldorp S et al (2020) Trends in mortality related to pulmonary embolism in the European Region, 2000-15: analysis of vital registration data from the WHO mortality database. Lancet Respir Med 8:277–87. https://doi.org/10.1016/S2213-2600(19)30354-6

Article  PubMed  Google Scholar 

Lung Cancer Statistics | How Common Is Lung Cancer? (2025) n.d. https://www.cancer.org/cancer/types/lung-cancer/about/key-statistics.html

Huang J, Deng Y, Tin MS, Lok V, Ngai CH, Zhang L et al (2022) Distribution, risk factors, and temporal trends for lung cancer incidence and mortality: a global analysis. Chest 161:1101–11. https://doi.org/10.1016/j.chest.2021.12.655

Article  PubMed  Google Scholar 

CDC. U.S. Cancer Statistics Lung Cancer Stat Bite (2025) United States Cancer Statistics 2025. https://www.cdc.gov/united-states-cancer-statistics/publications/lung-cancer-stat-bite.html (accessed September 8

Khorana AA, Noble S, Lee AYY, Soff G, Meyer G, O’Connell C et al (2018) Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: guidance from the SSC of the ISTH. J Thromb Haemost 16:1891–1894. https://doi.org/10.1111/jth.14219

Article  CAS  PubMed  Google Scholar 

Junjun L, Pei W, Ying Y, Kui S (2020) Prognosis and risk factors in older patients with lung cancer and pulmonary embolism: a propensity score matching analysis. Sci Rep 10:1272. https://doi.org/10.1038/s41598-020-58345-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

National Center for Health Statistics Mortality Data on Centers for Disease Control and Prevention Wide-Ranging ONline Data for Epidemiologic Research. https://wonder.cdc.gov/mcd.html

Ingram DD, Franco SJ (2014) 2013 NCHS urban-rural classification scheme for counties. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics

Joinpoint trend analysis software Joinpoint regression program, version 2016. Surveillance Research Program, National Cancer Institute. https://surveillance.cancer.gov/joinpoint/

Zhang YW, Tao R, Wu D, Ou JC, Kong ZC, Zhu ZZ (2025) Research progress on the association between lung cancer and pulmonary embolism. J Cardiothorac Surg 20(1):2. https://doi.org/10.1186/s13019-024-03321-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Wang H, Liu D, Li W (2024) Incidence and risk factors of VTE in lung cancer: a meta-analysis. Ann Med 56(1):2390200. https://doi.org/10.1080/07853890.2024.2390200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zantonelli G, Cozzi D, Bindi A, Cavigli E, Moroni C, Luvarà S, Grazzini G, Danti G, Granata V, Miele V (2022) Acute pulmonary embolism: prognostic role of computed tomography pulmonary angiography (CTPA). Tomography 8:529–539. https://doi.org/10.3390/tomography8010042

Article  PubMed  PubMed Central  Google Scholar 

Mederos N, Friedlaender A, Peters S, Addeo A (2020) Gender-specific aspects of epidemiology, molecular genetics and outcome: lung cancer. ESMO Open 5(Suppl 4):e000796. https://doi.org/10.1136/esmoopen-2020-000796

Article  PubMed  PubMed Central  Google Scholar 

Siegfried JM (2022) Sex and gender differences in lung cancer and chronic obstructive lung disease. Endocrinology 1(2):bqab254. https://doi.org/10.1210/endocr/bqab254

Article  CAS  Google Scholar 

Vavalà T, Catino A, Pizzutilo P, Longo V, Galetta D (2021) Gender differences and immunotherapy outcome in advanced lung cancer. Int J Mol Sci 22(4):11942. https://doi.org/10.3390/ijms222111942

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thachil R, Nagraj S, Kharawala A, Sokol SI (2022) Pulmonary embolism in women: a systematic review of the current literature. J Cardiovasc Dev Dis 9(25):234. https://doi.org/10.3390/jcdd9080234

Article  PubMed  PubMed Central  Google Scholar 

Warner ET (2022) Race, place, and socioeconomic status: a path toward lung cancer early detection. Cancer 128(15):3016–3018. https://doi.org/10.1002/cncr.34330

Article  PubMed  Google Scholar 

Potter AL, Senthil P, Srinivasan D, Raman V, Kumar A, Haridas C, Mathey-Andrews C, Zheng W, Jeffrey Yang CF (2024) Persistent race- and sex-based disparities in lung cancer screening eligibility. J Thorac Cardiovasc Surg 168(1):248-260.e2. https://doi.org/10.1016/j.jtcvs.2023.10.025

Article  PubMed  Google Scholar 

Cranford HM, Koru-Sengul T, Lopes G, Pinheiro PS (2023) Lung cancer incidence by detailed race-ethnicity. Cancers (Basel) 15(5):2164. https://doi.org/10.3390/cancers15072164

Article  PubMed  PubMed Central  Google Scholar 

Poulson MR, Kenzik KM, Singh S, Pavesi F, Steiling K, Litle VR, Suzuki K (2022) Redlining, structural racism, and lung cancer screening disparities. J Thorac Cardiovasc Surg 163(6):1920-1930.e2. https://doi.org/10.1016/j.jtcvs.2021.08.086

Article  PubMed  Google Scholar 

Jha SK, De Rubis G, Devkota SR, Zhang Y, Adhikari R, Jha LA, Bhattacharya K, Mehndiratta S, Gupta G, Singh SK, Panth N, Dua K, Hansbro PM, Paudel KR (2024) Cellular senescence in lung cancer: molecular mechanisms and therapeutic interventions. Ageing Res Rev 97:102315. https://doi.org/10.1016/j.arr.2024.102315

Article  CAS  PubMed  Google Scholar 

Zuin M, Nohria A, Henkin S, Krishnathasan D, Sato A, Piazza G (2025) Pulmonary embolism-related mortality in patients with cancer. JAMA Netw Open 8(2):e2460315. https://doi.org/10.1001/jamanetworkopen.2024.60315

Article  PubMed  PubMed Central  Google Scholar 

Zöller B, Connors JM (2024) Multimorbidity, comorbidity, frailty, and venous thromboembolism. Haematologica 109(12):3852–3859. https://doi.org/10.3324/haematol.2023.284579

Article  PubMed  PubMed Central  Google Scholar 

Moore P, Esmail F, Qin S, Nand S, Berg S (2022) Hypercoagulability of COVID-19 and neurological complications: a review. J Stroke Cerebrovasc Dis 31(1):106163. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106163

Article  PubMed  Google Scholar 

Witkowski JM, Fulop T, Bryl E (2022) Immunosenescence and COVID-19. Mech Ageing Dev 204:111672. https://doi.org/10.1016/j.mad.2022.111672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waeldner K, Kruglik CP, Halvorson-Phelan J, Lee JY, Taylor-Olson C, Hammond M, Fung MK, Carney JK (2024) Factors associated with the recruitment of primary care workforce in rural Vermont: a pilot study. Cureus 16(10):e71941. https://doi.org/10.7759/cureus.71941

Article  PubMed  PubMed Central  Google Scholar 

Hasson RM, Fay KA, Phillips JD, Millington TM, Finley DJ (2021) Rural barriers to early lung cancer detection: exploring access to lung cancer screening programs in New Hampshire and Vermont. Am J Surg 221(4):725–730. https://doi.org/10.1016/j.amjsurg.2020.06.030

Article  PubMed  Google Scholar 

Underwood JM, Townsend JS, Tai E, Davis SP, Stewart SL, White A, Momin B, Fairley TL (2012) Racial and regional disparities in lung cancer incidence. Cancer 118(7):1910–8. https://doi.org/10.1002/cncr.26479

Article  PubMed  Google Scholar 

Verplancke KB, Keirns DL, McMahon K, Creech ZA, Truong GT, Silberstein PT, Dahl MB (2023) Association between demographic and socioeconomic factors and diagnosis of advanced non-small cell lung cancer: an analysis of the National Cancer Database. Cureus 29;15(8):e44351. https://doi.org/10.7759/cureus.44351

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