Verso M, Agnelli G, Prandoni P (2015) Pros and cons of new oral anticoagulants in the treatment of venous thromboembolism in patients with cancer. Intern Emerg Med 10:651–656. https://doi.org/10.1007/s11739-015-1233-5
Douketis JD, Foster GA, Crowther MA, Prins MH, Ginsberg JS (2000) Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med 160:3431–3436. https://doi.org/10.1001/archinte.160.22.3431
Article CAS PubMed Google Scholar
Hutten BA, Prins MH, Gent M, Ginsberg J, Tijssen JG, Büller HR (2000) Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis. J Clin Oncol 18:3078–3083. https://doi.org/10.1200/jco.2000.18.17.3078
Article CAS PubMed Google Scholar
Palareti G, Legnani C, Lee A, Manotti C, Hirsh J, D’Angelo A, Pengo V, Moia M, Coccheri S (2000) A comparison of the safety and efficacy of oral anticoagulation for the treatment of venous thromboembolic disease in patients with or without malignancy. Thromb Haemost 84:805–810. https://doi.org/10.1055/s-0037-1614120
Article CAS PubMed Google Scholar
Prandoni P, Lensing AW, Piccioli A, Bernardi E, Simioni P, Girolami B, Marchiori A, Sabbion P, Prins MH, Noventa F, Girolami A (2002) Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 100:3484–3488. https://doi.org/10.1182/blood-2002-01-0108
Article CAS PubMed Google Scholar
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003) Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 349:146–153. https://doi.org/10.1056/NEJMoa025313
Article CAS PubMed Google Scholar
Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Gates LE, Kakkar AK, Tempero MA, Gupta S, Lyman GH, Falanga A (2023) Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO guideline update. J Clin Oncol 41:3063–3071. https://doi.org/10.1200/jco.23.00294
Article CAS PubMed Google Scholar
Streiff MB, Holmstrom B, Angelini D, Ashrani A, Buckner T, Diep R et al (2025) Cancer-Associated Venous Thromboembolic Disease, Version 2.2025, NCCN Clinical Practice Guidelines in Oncology. https://www.nccn.org/professionals/physician_gls/pdf/vte.pdf. Accessed 15 Oct 2025
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies (2004) Lancet 363:157–163. https://doi.org/10.1016/S0140-6736(0)15268-3
Ten Cate H (2013) New oral anticoagulants: discussion on monitoring and adherence should start now! Thromb J 11:8. https://doi.org/10.1186/1477-9560-11-8
Article CAS PubMed PubMed Central Google Scholar
Martin K, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S (2016) Use of the direct oral anticoagulants in obese patients: guidance from the ssc of the ISTH. J Thromb Haemost 14:1308–1313. https://doi.org/10.1111/jth.13323
Article CAS PubMed PubMed Central Google Scholar
Martin KA, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S (2021) Use of direct oral anticoagulants in patients with obesity for treatment and prevention of venous thromboembolism: updated communication from the ISTH ssc subcommittee on control of anticoagulation. J Thromb Haemost 19:1874–1882. https://doi.org/10.1111/jth.15358
Kaatz S, Ahmad D, Spyropoulos AC, Schulman S (2015) Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost 13:2119–2126. https://doi.org/10.1111/jth.13140
Article CAS PubMed Google Scholar
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377–381. https://doi.org/10.1016/j.jbi.2008.08.010
McBane RD 2nd, Wysokinski WE, Le-Rademacher JG, Zemla T, Ashrani A, Tafur A, Perepu U, Anderson D, Gundabolu K, Kuzma C, Perez Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Houghton DE, Vishnu P, Loprinzi CL (2020) Apixaban and dalteparin in active malignancy-associated venous thromboembolism: The ADAM VTE trial. J Thromb Haemost 18:411–421. https://doi.org/10.1111/jth.14662
Article CAS PubMed Google Scholar
Agnelli G, Becattini C, Meyer G, Muñoz A, Huisman MV, Connors JM, Cohen A, Bauersachs R, Brenner B, Torbicki A, Sueiro MR, Lambert C, Gussoni G, Campanini M, Fontanella A, Vescovo G, Verso M (2020) Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 382:1599–1607. https://doi.org/10.1056/NEJMoa1915103
Article CAS PubMed Google Scholar
Young AM, Marshall A, Thirlwall J, Chapman O, Lokare A, Hill C, Hale D, Dunn JA, Lyman GH, Hutchinson C, MacCallum P, Kakkar A, Hobbs FDR, Petrou S, Dale J, Poole CJ, Maraveyas A, Levine M (2018) Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D). J Clin Oncol 36:2017–2023. https://doi.org/10.1200/jco.2018.78.8034
Article CAS PubMed Google Scholar
Nutescu EA, Spinler SA, Wittkowsky A, Dager WE (2009) Low-molecular-weight heparins in renal impairment and obesity: available evidence and clinical practice recommendations across medical and surgical settings. Ann Pharmacother 43:1064–1083. https://doi.org/10.1345/aph.1L194
Article CAS PubMed Google Scholar
Sebaaly J, Covert K (2018) Enoxaparin dosing at extremes of weight: literature review and dosing recommendations. Ann Pharmacother 52:898–909. https://doi.org/10.1177/1060028018768449
Article CAS PubMed Google Scholar
Abildgaard A, Madsen SA, Hvas AM (2020) Dosage of anticoagulants in obesity: recommendations based on a systematic review. Semin Thromb Hemost 46:932–969. https://doi.org/10.1055/s-0040-1718405
Wysokinski WE, Froehling DA, Houghton DE, McBane RD, Vlazny DT, Bott-Kitslaar DM, Kuczmik W, Sutkowska K, Bator K, Hodge DO, Peterson LG, Casanegra AI (2020) Effectiveness and safety of apixaban and rivaroxaban for acute venous thromboembolism therapy in patients with extremes in bodyweight. Eur J Haematol 105:484–494. https://doi.org/10.1111/ejh.13471
Article CAS PubMed Google Scholar
Karakasis P, Ktenopoulos N, Pamporis K, Sagris M, Soulaidopoulos S, Gerogianni M, Leontsinis I, Giannakoulas G, Tousoulis D, Fragakis N, Tsioufis K (2024) Efficacy and safety of direct oral anticoagulants versus warfarin in obese patients (BMI ≥ 30 kg/m(2)) with atrial fibrillation or venous thromboembolism: an updated systematic review and meta-analysis. J Clin Med 13:3784. https://doi.org/10.3390/jcm13133784
Article CAS PubMed PubMed Central Google Scholar
Wang TF, Carrier M, Fournier K, Siegal DM, Le Gal G, Delluc A (2022) Oral anticoagulant use in patients with morbid obesity: a systematic review and meta-analysis. Thromb Haemost 122:830–841. https://doi.org/10.1055/a-1588-9155
Park DY, An S, Arif AW, Sana MK, Vij A (2023) Factor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis. BMC Cardiovasc Disord 23:100. https://doi.org/10.1186/s12872-023-03067-4
Article PubMed PubMed Central Google Scholar
Sebaaly J, Kelley D (2020) Direct oral anticoagulants in obesity: an updated literature review. Ann Pharmacother 54:1144–1158. https://doi.org/10.1177/1060028020923584
Potere N, Di Nisio M, Porreca E, Wang TF, Tagalakis V, Shivakumar S, Delluc A, Mallick R, Wells PS, Carrier M (2023) Apixaban thromboprophylaxis in ambulatory patients with cancer and obesity: insights from the AVERT trial. Thromb Res 226:82–85. https://doi.org/10.1016/j.thromres.2023.04.015
Article CAS PubMed Google Scholar
Kubitza D, Becka M, Zuehlsdorf M, Mueck W (2007) Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59–7939) in healthy subjects. J Clin Pharmacol 47:218–226. https://doi.org/10.1177/0091270006296058
Article CAS PubMed Google Scholar
Upreti VV, Wang J, Barrett YC, Byon W, Boyd RA, Pursley J, LaCreta FP, Frost CE (2013) Effect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjects. Br J Clin Pharmacol 76:908–916. https://doi.org/10.1111/bcp.12114
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