Umapathi KK, Nguyen H. Cardiopulmonary Fitness. 2020.

Hawkins MN, Raven PB, Snell PG, Stray-Gundersen J, Levine BD. Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity. Med Sci Sports Exerc. 2007;39:103–7.

PubMed  Google Scholar 

Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128:873–934.

Article  PubMed  Google Scholar 

Martin-Rincon M, Calbet JA. Progress update and challenges on V. O2max testing and interpretation. Front Physiol. 2020;11:1070.

Article  PubMed  PubMed Central  Google Scholar 

McElroy PA, Janicki JS, Weber KT. Cardiopulmonary exercise testing in congestive heart failure. Am J Cardiol. 1988;62:a35–40. https://doi.org/10.1016/s0002-9149(88)80083-3.

Leduc-Gaudet JP, Hussain SNA, Barreiro E, Gouspillou G. Mitochondrial dynamics and mitophagy in skeletal muscle health and aging. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22158179.

Article  PubMed  PubMed Central  Google Scholar 

O’Donnell DE, Milne KM, Vincent SG, Neder JA. Unraveling the causes of unexplained dyspnea: the value of exercise testing. Clin Chest Med. 2019;40:471–99. https://doi.org/10.1016/j.ccm.2019.02.014.

Article  PubMed  Google Scholar 

Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143:eS166–90.

Article  Google Scholar 

Kaminsky LA, Myers J, Brubaker PH, Franklin BA, Bonikowske AR, German C, et al. 2023 update: the importance of cardiorespiratory fitness in the United States. Prog Cardiovasc Dis. 2024;83:3–9. https://doi.org/10.1016/j.pcad.2024.01.020.

Article  PubMed  Google Scholar 

Ross R, Arena R, Myers J, Kokkinos P, Kaminsky LA. Update to the 2016 American Heart Association cardiorespiratory fitness statement. Prog Cardiovasc Dis. 2024;83:10–5. https://doi.org/10.1016/j.pcad.2024.02.003.

Article  PubMed  Google Scholar 

Bonikowske AR, Taylor JL, Larson KF, Hardwick J, Ozemek C, Harber MP, et al. Evaluating current assessment techniques of cardiorespiratory fitness. Expert Rev Cardiovasc Ther. 2024;22:231–41. https://doi.org/10.1080/14779072.2024.2363393.

Article  PubMed  CAS  Google Scholar 

Abut F, Akay MF, George J. Developing new VO(2)max prediction models from maximal, submaximal and questionnaire variables using support vector machines combined with feature selection. Comput Biol Med. 2016;79:182–92. https://doi.org/10.1016/j.compbiomed.2016.10.018.

Article  PubMed  Google Scholar 

Malhotra R, Bakken K, D’Elia E, Lewis GD. Cardiopulmonary exercise testing in heart failure. JACC: Heart Failure. 2016;4:607–16. https://doi.org/10.1016/j.jchf.2016.03.022.

Article  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. J Am Coll Cardiol. 2022;79:e263-421.

Article  PubMed  Google Scholar 

Arena R, Myers J, Guazzi M. The clinical and research applications of aerobic capacity and ventilatory efficiency in heart failure: an evidence-based review. Heart Fail Rev. 2008;13:245–69. https://doi.org/10.1007/s10741-007-9067-5.

Article  PubMed  Google Scholar 

Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118:3272–87. https://doi.org/10.1093/cvr/cvac013.

Article  PubMed  CAS  Google Scholar 

O’Neill JO, Young JB, Pothier CE, Lauer MS. Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers. Circulation. 2005;111:2313–8. https://doi.org/10.1161/01.Cir.0000164270.72123.18.

Article  PubMed  Google Scholar 

Myers J, Gullestad L, Vagelos R, Do D, Bellin D, Ross H, Fowler MB. Clinical, hemodynamic, and cardiopulmonary exercise test determinants of survival in patients referred for evaluation of heart failure. Ann Intern Med. 1998;129:286–93.

Article  PubMed  CAS  Google Scholar 

Cahalin LP, Chase P, Arena R, Myers J, Bensimhon D, Peberdy MA, Ashley E, West E, Forman DE, Pinkstaff S. A meta-analysis of the prognostic significance of cardiopulmonary exercise testing in patients with heart failure. Heart Fail Rev. 2013;18:79–94.

Article  PubMed  PubMed Central  Google Scholar 

Lim FY, Yap J, Gao F, Teo LL, Lam CSP, Yeo KK. Correlation of the new York Heart Association classification and the cardiopulmonary exercise test: a systematic review. Int J Cardiol. 2018;263:88–93. https://doi.org/10.1016/j.ijcard.2018.04.021.

Article  PubMed  Google Scholar 

Hammett R, Fleri Soler J, Gauci M, Desira J, Abela M. Are you short of breath? Comparing functional capacity using new York heart association class and cardiopulmonary exercise testing. Eur J Prev Cardiol. 2023. https://doi.org/10.1093/eurjpc/zwad125.052.

Article  Google Scholar 

Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH Jr., Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778–86. https://doi.org/10.1161/01.cir.83.3.778.

Article  PubMed  CAS  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary: a report of the American college of cardiology/american heart association joint committee on clinical practice guidelines. Circulation. 2022;145:e876-94. https://doi.org/10.1161/cir.0000000000001062.

Article  PubMed  Google Scholar 

Mehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, Baran DA, et al. The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant. 2016;35:1–23. https://doi.org/10.1016/j.healun.2015.10.023.

Article  PubMed  Google Scholar 

Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi S, AlKatheeri R, Alblooshi FMK, Almatrooshi M, Alzaabi MEH, Al Darmaki RS, et al. Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus. 2020;12:e9349. https://doi.org/10.7759/cureus.9349.

Article  PubMed  PubMed Central  Google Scholar 

Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, et al. Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. Am J Cardiol. 2009;103:615–9. https://doi.org/10.1016/j.amjcard.2008.10.034.

Article  PubMed  PubMed Central  Google Scholar 

Belardinelli R, Lacalaprice F, Carle F, Minnucci A, Cianci G, Perna G, D’Eusanio G. Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing. Eur Heart J. 2003;24:1304–13. https://doi.org/10.1016/s0195-668x(03)00210-0.

Article  PubMed  Google Scholar 

Munhoz EC, Hollanda R, Vargas JP, Silveira CW, Lemos AL, Hollanda RM, et al. Flattening of oxygen pulse during exercise may detect extensive myocardial ischemia. Med Sci Sports Exerc. 2007;39:1221–6. https://doi.org/10.1249/mss.0b013e3180601136.

Article  PubMed  Google Scholar 

Upton MT, Rerych SK, Newman GE, Port S, Cobb FR, Jones RH. Detecting abnormalities in left ventricular function during exercise before angina and ST-segment depression. Circulation. 1980;62:341–9. https://doi.org/10.1161/01.cir.62.2.341.

Article  PubMed  CAS  Google Scholar 

Humphries KH, Pu A, Gao M, Carere RG, Pilote L. Angina with normal coronary arteries: sex differences in outcomes. Am Heart J. 2008;155:375–81. https://doi.org/10.1016/j.ahj.2007.10.019.

Article  PubMed  Google Scholar 

Sara JD, Widmer RJ, Matsuzawa Y, Lennon RJ, Lerman LO, Lerman A. Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease. JACC Cardiovasc Interv. 2015;8:1445–53. https://doi.org/10.1016/j.jcin.2015.06.017.

Article  PubMed  Google Scholar 

Tari AR, Walker TL, Huuha AM, Sando SB, Wisloff U. Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing. Lancet. 2025;405:1093–118. https://doi.org/10.1016/s0140-6736(25)00184-9.

Article