Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?

World Health Organization. Political declaration of the fourth high-level meeting of the General Assembly on the prevention and control of noncommunicable diseases and the promotion of mental health and well-being [Internet]. Geneva: WHO; [cited 2025 Nov 04]. Available from: https://www.who.int/publications/m/item/rev.4--political-declaration-of-the-fourth-high-level-meeting-of-the-general-assembly-on-theprevention-and-control-of-noncommunicable-diseases-and-the-promotion-of-mental-healthand-well-being

Global Burden of Cardiovascular Diseases and Risks 2023 Collaborators: Global, regional, and national burden of cardiovascular diseases and risk factors in 204 countries and territories, 1990–2023. J Am Coll Cardiol. 2025, 86(22):2167–2243. https://doi.org/10.1016/j.jacc.2025.08.015.

Global effect of cardiovascular risk factors on Lifetime estimates. New England Journal of Medicine. 2025, 393(2):125–38. https://doi.org/10.1056/nejmoa2415879

Chong B, Jayabaskaran J, Jauhari SM, Chan SP, Goh R, Kueh MT, et al. Global burden of cardiovascular diseases: projections from 2025 to 2050. Eur J Prev Cardiol. 2024;32(11):1001–15. https://doi.org/10.1093/eurjpc/zwae281.

Article  Google Scholar 

Chong B, Jayabaskaran J, Jauhari SM, Chia J, le Roux CW, Mehta A, et al. The global syndemic of modifiable cardiovascular risk factors projected from 2025 to 2050. J Am Coll Cardiol. 2025;86(3):165–77. https://doi.org/10.1016/j.jacc.2025.04.061.

Article  PubMed  PubMed Central  Google Scholar 

World Population Projections [Internet]. [cited 2025 Nov 12]. Available from: https://www.worldometers.info/world-population/world-population-projections/

Du H, Shi Q, Song P, Pan X-F, Yang X, Chen L, et al. Global burden attributable to high low-density lipoprotein-cholesterol from 1990 to 2019. Frontiers in Cardiovascular Medicine. 2022;9:9. https://doi.org/10.3389/fcvm.2022.903126.

Article  CAS  Google Scholar 

Cotton A, Salerno PR, Chen Z, Virani S, Sattar N, Rajagopalan S, et al. Forecasting atherosclerotic cardiovascular disease in South Asia until 2040. JACC: Asia. 2025;5(10):1359–68. https://doi.org/10.1016/j.jacasi.2025.06.014.

Article  PubMed  PubMed Central  Google Scholar 

Navaneetham K, Arunachalam D. Global Population Aging, 1950–2050 [Internet]. Springer Nature Singapore; 1970 [cited 2025 Nov 12]. https://doi.org/10.1007/978-981-99-7842-7_154

Anand VV, Zhe EL, Chin YH, Goh RS, Lin C, Kueh MT, et al. Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: a meta-analysis using multidimensional socioeconomic status indices. Int J Cardiol. 2023;383:140–50. https://doi.org/10.1016/j.ijcard.2023.04.042.

Article  PubMed  Google Scholar 

Ng M, Gakidou E, Lo J, Abate Y, Abbafati C, Abbas N, et al. Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: A forecasting study for the global burden of disease study 2021. The Lancet. 2025;405(10481):813–38. https://doi.org/10.1016/s0140-6736(25)00355-1.

Article  Google Scholar 

United Nations Department of Economic and Social Affairs, Population Division. World Population Prospects 2024: Median age projections for 2050 [Internet]. New York: United Nations; 2024 [cited 2025 Nov 27]. Available from: https://database.earth/population/median-age/2050

Institute for Health Metrics and Evaluation. Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats [Internet]. Seattle (WA): IHME; 2024 May 16 [cited 2025 Nov 27]. Available from: https://www.healthdata.org/news-events/newsroom/news-releases/global-life-expectancy-increase-nearly-5-years-2050-despite

Hewitt M. The road to 10 billion: World population projections 2024 [Internet]. 2025 [cited 2025 Nov 5]. Available from: https://populationmatters.org/news/2024/07/the-road-to-10-billion-world-population-projections-2024/

Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA. 1983;250(3):370–3.

Article  PubMed  CAS  Google Scholar 

Martino F, Bassareo PP, Martino E, Romeo F, Calcaterra G, Perrone Filardi P, et al. Cardiovascular prevention in childhood: a consensus document of the Italian Society of Cardiology Working Group on congenital heart disease and cardiovascular prevention in paediatric age. J Cardiovasc Med. 2023;24(8):492–505. https://doi.org/10.2459/jcm.0000000000001488.

Article  Google Scholar 

Johnson CC, Nicklas TA, Arbeit ML, Harsha DW, Mott DS, Hunter SM, et al. Cardiovascular intervention for high-risk families: the heart smart program. South Med J. 1991;84(11):1305–12. https://doi.org/10.1097/00007611-199111000-00004.

Article  PubMed  CAS  Google Scholar 

Strieter L, Meyer D, Kim S. Knowing your audience: a narrative review of culturally tailored health programs for youth. Prog Cardiovasc Dis. 2025;90:71–8. https://doi.org/10.1016/j.pcad.2025.02.002.

Article  PubMed  Google Scholar 

Soneji S, Barrington-Trimis JL, Wills TA, Leventhal AM, Unger JB, Gibson LA, et al. Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: a systematic review and meta-analysis. JAMA Pediatr. 2017;171(8):788–97. https://doi.org/10.1001/jamapediatrics.2017.1488.

Article  PubMed  PubMed Central  Google Scholar 

Chung RJ, Touloumtzis C, Gooding H. Staying young at heart: cardiovascular disease prevention in adolescents and young adults. Curr Treat Options Cardiovasc Med. 2015;17(12):61. https://doi.org/10.1007/s11936-015-0414-x.

Article  PubMed  PubMed Central  Google Scholar 

Lloyd-Jones DM, Allen NB, Anderson CAM, Black T, Brewer LC, Foraker RE, et al. Life’s essential 8: Updating and enhancing the American Heart Association’s construct of Cardiovascular Health: A presidential advisory from the American Heart Association. Circulation. 2022, 146(5). https://doi.org/10.1161/cir.0000000000001078

Gaffey AE, Rollman BL, Burg MM. Strengthening the pillars of cardiovascular health: Psychological health is a crucial component. Circulation. 2024;149(9):641–3. https://doi.org/10.1161/circulationaha.123.066132.

Article  PubMed  PubMed Central  Google Scholar 

Schipper HS, de Ferranti S. Cardiovascular risk assessment and management for pediatricians. Pediatrics. 2022;150(6). https://doi.org/10.1542/peds.2022-057957

Perak AM, Ning H, Khan SS, Bundy JD, Allen NB, Lewis CE, et al. Associations of late adolescent or young adult cardiovascular health with premature cardiovascular disease and mortality. J Am Coll Cardiol. 2020;76(23):2695–707. https://doi.org/10.1016/j.jacc.2020.10.002.

Article  PubMed  PubMed Central  Google Scholar 

Navar AM, Fine LJ, Ambrosius WT, Brown A, Douglas PS, Johnson K, et al. Earlier treatment in adults with high lifetime risk of cardiovascular diseases: what prevention trials are feasible and could change clinical practice? Report of a national heart, Lung, and Blood Institute (NHLBI) workshop. Am J Prev Cardiol. 2022;12:100430. https://doi.org/10.1016/j.ajpc.2022.100430.

Article  PubMed  PubMed Central  Google Scholar 

Schwalm JD, McKee M, Huffman MD, Yusuf S. Resource effective strategies to prevent and treat cardiovascular disease. Circulation. 2016;133(8):742–55. https://doi.org/10.1161/circulationaha.115.008721.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gooding HC, Gidding SS, Moran AE, Redmond N, Allen NB, Bacha F, et al. Challenges and opportunities for the prevention and treatment of cardiovascular disease among young adults: Report from a National Heart, Lung, and Blood Institute Working Group. Journal of the American Heart Association. 2020;9(19). https://doi.org/10.1161/jaha.120.016115

Liu Z, Yan M, Tse LA, Zhu Y, Lang X, Liu X, et al. Achievement of guideline-recommended targets for secondary prevention of cardiovascular disease in 38 low-income and middle-income countries. J Epidemiol Glob Health. 2024;14(3):1022–31. https://doi.org/10.1007/s44197-024-00251-3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Orkaby AR, Onuma O, Qazi S, Gaziano JM, Driver JA. Preventing cardiovascular disease in older adults: one size does not fit all. Cleve Clin J Med. 2018;85(1):55–64. https://doi.org/10.3949/ccjm.85a.16119.

Article  PubMed  Google Scholar 

Johansson J, Deraas TS, Hopstock LA, Henriksen A, Grimsgaard S. Improving and preserving cardiorespiratory fitness, muscle strength and adiposity through a complex lifestyle intervention in community-dwelling older adults with elevated cardiometabolic risk: Study protocol for the restart randomised controlled trial. BMJ Open. 2025;15(4). https://doi.org/10.1136/bmjopen-2024-095810

Miguel Goncalves C, Cabral M, Carvalho M, Vazao A, Pereira J, Amado M, et al. Secondary prevention after one-year of a cardiovascular rehabilitation program: A single-centre analysis. European Journal of Preventive Cardiology. 2025;32(1):331. https://doi.org/10.1093/eurjpc/zwaf236.331.

Article  Google Scholar 

Johansen ND, Modin D, Loiacono MM, Harris RC, Dufournet M, Larsen CS, et al. High-dose influenza vaccine effectiveness against hospitalization in older adults. N Engl J Med. 2025. https://doi.org/10.1056/nejmoa2509907.

Article  PubMed  Google Scholar 

Heidenreich PA. Giga-Trials Support Vaccination as secondary prevention for cardiovascular disease. JACC. 2025. https://doi.org/10.1016/j.jacc.2025.09.1609.

Article  PubMed  PubMed Central  Google Scholar 

Collaboration AT. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324(7329):71–86. https://doi.org/10.1136/bmj.324.7329.71.

Article  Google Scholar 

Lehtisalo J, Rusanen M, Solomon A, Antikainen R, Laatikainen T, Peltonen M, et al. Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the finger trial. Eur Heart J. 2022;43(21):2054–61. https://doi.org/10.1093/eurheartj/ehab922.

Article  PubMed  PubMed Central  Google Scholar 

Baghaei A, Sarrafzadegan N, Rabiei K, Gharipour M, Tavasoli AA, Shirani S, et al. Research paperhow effective are strategies for non-communicable disease prevention and control in a high risk population in a developing country? Isfahan Healthy Heart Programme. Arch Med Sci. 2010;1:24–31. https://doi.org/10.5114/aoms.2010.13503.

Article  Google Scholar 

Bosch J, Lonn EM, Jung H, Zhu J, Liu L, Lopez-Jaramillo P, et al. Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants. European Heart Journal. 2021;42(31):2995–3007. https://doi.org/10.1093/eurheartj/ehab225.

Article  PubMed  PubMed Central 

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