Feasibility of Quantitative Myocardial Perfusion with CZT SPECT and SPECT/CT: Current Limitations and Recommendations for Future Improvements

Di Carli MF, Springer. Changing epidemiology of CAD: why should we pay attention? J Nucl Cardiol. 2021;28(2):386–8. https://doi.org/10.1007/s12350-021-02560-7.

Article  PubMed  Google Scholar 

Kadrmas DJ, Di Bella EVR, Khare HS, Christian PE, Gullberg GT. Static versus dynamic teboroxime myocardial perfusion SPECT in canines. IEEE Trans Nucl Sci. 2000;47(3):1112–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Bella EV, Ross SG, Kadrmas DJ, et al. Compartmental modeling of technetium-99m-labeled teboroxime with dynamic single-photon emission computed tomography: comparison with static thallium-201 in a canine model. Invest Radiol. 2001;36(3):178–85. https://doi.org/10.1097/00004424-200103000-00007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iida H, Eberl S. Quantitative assessment of regional myocardial blood flow with thallium-201 and SPECT. J Nucl Cardiol. 1998;5:313–31.

Article  CAS  PubMed  Google Scholar 

Iida H, Eberl S, Kim KM, et al. Absolute quantitation of myocardial blood flow with (201)Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling. Eur J Nucl Med Mol Imaging. 2008;35(5):896–905. https://doi.org/10.1007/s00259-007-0654-4.

Article  PubMed  Google Scholar 

Gullberg GT, Reutter BW, Sitek A, Maltz JS, Budinger TF. Dynamic single photon emission computed tomography–basic principles and cardiac applications. Phys Med Biol. 2010;55(20):R111–91. https://doi.org/10.1088/0031-9155/55/20/R01.

Article  PubMed  PubMed Central  Google Scholar 

Chiao PC, Ficaro EP, Dayanikli F, Rogers WL, Schwaiger M. Compartmental analysis of technetium-99m-teboroxime kinetics employing fast dynamic SPECT at rest and stress. J Nucl Med. 1994;35(8):1265–73.

CAS  PubMed  Google Scholar 

Otaki Y, Manabe O, Miller RJH, et al. Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with 15O-water PET. J Nucl Cardiol. 2021;28(4):1477–86. https://doi.org/10.1007/s12350-019-01854-1.

Article  PubMed  Google Scholar 

Cuddy-Walsh SG, deKemp RA, Ruddy TD, Wells RG. Improved precision of SPECT myocardial blood flow using a net tracer retention model. Med Phys. 2023;50(4):2009–21. https://doi.org/10.1002/mp.16186.

Article  PubMed  Google Scholar 

Wells RG, Timmins R, Klein R, et al. Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model. J Nucl Med. 2014;55(10):1685–91. https://doi.org/10.2967/jnumed.114.139782.

Article  CAS  PubMed  Google Scholar 

Chng AC, Keng BM, Teng XF, et al. Going beyond summed stress scores: correlating global and territorial coronary flow reserve by single photon emission tomography with routine myocardial perfusion imaging. Heliyon. 2024. https://doi.org/10.1016/j.heliyon.2024.e29629.

Article  PubMed  PubMed Central  Google Scholar 

Han S, Kim YH, Ahn JM, et al. Feasibility of dynamic stress 201Tl/rest 99mTc-tetrofosmin single photon emission computed tomography for quantification of myocardial perfusion reserve in patients with stable coronary artery disease. Eur J Nucl Med Mol Imaging. 2018;45(12):2173–80. https://doi.org/10.1007/s00259-018-4057-5.

Article  CAS  PubMed  Google Scholar 

Wieting W, Bengel FM, Diekmann J. Comparison of global and regional myocardial blood flow quantification using dynamic solid-state detector SPECT and Tc-99 m-sestamibi or Tc-99 m-tetrofosmin in a routine clinical setting. Int J Cardiovasc Imaging. 2025(3). https://doi.org/10.1007/s10554-025-03339-4.

Ferenczi P, Couffinhal T, Mamou A, et al. Myocardial blood flows and reserves on solid state camera: correlations with coronary history and cardiovascular risk factors. J Nucl Cardiol. 2022;29(4):1671–8. https://doi.org/10.1007/s12350-021-02659-x.

Article  PubMed  Google Scholar 

Bailly M, Thibault F, Courtehoux M, Metrard G, Angoulvant D, Ribeiro MJ. Myocardial flow reserve measurement during CZT-SPECT perfusion imaging for coronary artery disease screening: correlation with clinical findings and invasive coronary angiography—the CFR-OR study. Front Med (Lausanne). 2021. https://doi.org/10.3389/fmed.2021.691893.

Article  PubMed  PubMed Central  Google Scholar 

Ben-Haim S, Murthy VL, Breault C, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: a feasibility study. J Nucl Med. 2013;54:873–9. https://doi.org/10.2967/jnumed.112.109652.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyagawa M, Nishiyama Y, Uetani T, et al. Estimation of myocardial flow reserve utilizing an ultrafast cardiac SPECT: comparison with coronary angiography, fractional flow reserve, and the SYNTAX score. Int J Cardiol. 2017;244:347–53. https://doi.org/10.1016/j.ijcard.2017.06.012.

Article  PubMed  Google Scholar 

Shiraishi S, Tsuda N, Sakamoto F, et al. Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging. J Cardiol. 2020;75(4):400–9. https://doi.org/10.1016/j.jjcc.2019.09.006.

Article  PubMed  Google Scholar 

Zavadovsky KV, Mochula AV, Maltseva AN, et al. The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients. J Nucl Cardiol. 2022;29(3):1051–63. https://doi.org/10.1007/s12350-020-02395-8.

Article  PubMed  Google Scholar 

Liu FS, Wang SY, Shiau YC, Wu YW. Integration of quantitative absolute myocardial blood flow estimates from dynamic CZT-SPECT improves the detection of coronary artery disease. J Nucl Cardiol. 2022;29(5):2311–21. https://doi.org/10.1007/s12350-021-02713-8.

Article  PubMed  Google Scholar 

de Souza AC do AH, Gonçalves BKD, Tedeschi AL, Lima RSL. Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease. J Nuclear Cardiol. 2021;28(3):876–84. https://doi.org/10.1007/s12350-019-01775-z.

Iguchi N, Utanohara Y, Suzuki Y, et al. Myocardial flow reserve derived by dynamic perfusion single-photon emission computed tomography reflects the severity of coronary atherosclerosis. Int J Cardiovasc Imaging. 2018;34(9):1493–501. https://doi.org/10.1007/s10554-018-1358-5.

Article  PubMed  Google Scholar 

Zhang J, Xie J, Li M, Fang W, Hsu B. SPECT myocardial blood flow quantitation for the detection of angiographic stenoses with cardiac-dedicated CZT SPECT. J Nucl Cardiol. 2023. https://doi.org/10.1007/s12350-023-03334-z.

Article  PubMed  Google Scholar 

Zavadovsky KV, Mochula AV, Boshchenko AA, et al. Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy. J Nuclear Cardiol. 2021;28(1):249–59. https://doi.org/10.1007/s12350-019-01678-z.

Article  Google Scholar 

Acampa W, Assante R, Mannarino T, et al. Low-dose dynamic myocardial perfusion imaging by CZT-SPECT in the identification of obstructive coronary artery disease. Eur J Nucl Med Mol Imaging. 2020;47(7):1705–12. https://doi.org/10.1007/s00259-019-04644-6.

Article  CAS  PubMed  Google Scholar 

Panjer M, Dobrolinska M, Wagenaar NRL, Slart RHJA. Diagnostic accuracy of dynamic CZT-SPECT in coronary artery disease. A systematic review and meta-analysis. Journal Nuclear Cardiology Springer. 2022;29(4):1686–97. https://doi.org/10.1007/s12350-021-02721-8.

Article  Google Scholar 

Gould KL, Johnson NP, Bateman TM, et al. Anatomic versus physiologic assessment of coronary artery disease: role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62(18):1639–53. https://doi.org/10.1016/j.jacc.2013.07.076.

Article  PubMed  Google Scholar 

Wells RG, Marvin B, Poirier M, Renaud JM, DeKemp RA, Ruddy TD. Optimization of SPECT measurement of myocardial blood flow with corrections for attenuation, motion, and blood-binding compared to PET. J Nucl Med. 2017;58:2013–9. https://doi.org/10.2967/jnumed.117.191049.

Article  CAS  PubMed  Google Scholar 

Giubbini R, Bertoli M, Durmo R, et al. Comparison between N13NH3-PET and 99mTc-Tetrofosmin-CZT SPECT in the evaluation of absolute myocardial blood flow and flow reserve. J Nucl Cardiol. 2021;28(5):1906–18. https://doi.org/10.1007/s12350-019-01939-x.

Article  PubMed  Google Scholar 

Agostini D, Roule V, Nganoa C, et al. First validation of myocardial flow reserve assessed by dynamic 99m Tc-sestamibi CZT-SPECT camera: head to head comparison with 15 O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study. Eur J Nucl Med Mol Imaging. 2018;45:1079–90. https://doi.org/10.1007/s00259-018-3958-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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