Members WG, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Stroke Statistics Subcommittee. Heart disease and stroke Statistics-2016 update: A report from the American heart association. Circulation. 2016;133(4):e38–360. https://doi.org/10.1161/CIR.0000000000000350.
Lin Y, Fu S, Yao Y, et al. Heart failure with preserved ejection fraction based on aging and comorbidities. J Transl Med. 2021;19:291. https://doi.org/10.1186/s12967-021-02935-x.
Article PubMed PubMed Central Google Scholar
Strait JB, Lakatta EG. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin. 2012;8(1):143–64. https://doi.org/10.1016/j.hfc.2011.08.011.
Article PubMed PubMed Central Google Scholar
Kitzman DW, Shah SJ. The HFpEF obesity phenotype: the elephant in the room. J Am Coll Cardiol. 2016;68(2):200–3. https://doi.org/10.1016/j.jacc.2016.05.019.
Lesnefsky EJ, Chen Q, Hoppel CL. Mitochondrial metabolism in aging heart. Circul Res. 2016;118(10):1593–611. https://doi.org/10.1161/CIRCRESAHA.116.307505.
Dai DF, Chen T, Johnson SC, Szeto H, Rabinovitch PS. Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal. 2012;16(12):1492–526. https://doi.org/10.1089/ars.2011.4179.
Article CAS PubMed PubMed Central Google Scholar
North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circul Res. 2012;110(8):1097–108. https://doi.org/10.1161/CIRCRESAHA.111.246876.
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Investig. 2009;119(9):2758–71. https://doi.org/10.1172/JCI39162.
Article CAS PubMed PubMed Central Google Scholar
Houtkooper R, Argmann C, Houten S, et al. The metabolic footprint of aging in mice. Sci Rep. 2011;1:134. https://doi.org/10.1038/srep00134.
Article CAS PubMed PubMed Central Google Scholar
Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima TS, N., Otsu K. Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy. 2010;6(5):600–6. https://doi.org/10.4161/auto.6.5.11947.
Article CAS PubMed Google Scholar
Fujimoto N, Prasad A, Hastings JL, Arbab-Zadeh A, Bhella PS, Shibata S, Palmer D, Levine BD. Cardiovascular effects of 1 year of progressive and vigorous exercise training in previously sedentary individuals older than 65 years of age. Circulation. 2010;122(18):1797–805. https://doi.org/10.1161/CIRCULATIONAHA.110.973784.
Article PubMed PubMed Central Google Scholar
Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014;5:3557. https://doi.org/10.1038/ncomms4557.
Article CAS PubMed Google Scholar
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA. Metformin as a tool to target aging. Cell Metabol. 2016;23(6):1060–5. https://doi.org/10.1016/j.cmet.2016.05.011.
Actis Dato V, Lange S, Cho Y. Metabolic flexibility of the heart: the role of fatty acid metabolism in health, heart failure, and cardiometabolic diseases. Int J Mol Sci. 2024;25(2):1211. https://doi.org/10.3390/ijms25021211.
Article CAS PubMed PubMed Central Google Scholar
Riera CE, Dillin A. Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol. 2015;17(3):196–203. https://doi.org/10.1038/ncb3107.
Article CAS PubMed Google Scholar
Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA. 2002;99(23):14988–93. https://doi.org/10.1073/pnas.232308999.
Article CAS PubMed PubMed Central Google Scholar
Goldberg IJ, Trent CM, Schulze PC. Lipid metabolism and toxicity in the heart. Cell Metabol. 2012;15(6):805–12. https://doi.org/10.1016/j.cmet.2012.04.006.
Fleg JL, Aronow WS, Frishman WH. Cardiovascular drug therapy in the elderly: benefits and challenges. Nat Rev Cardiol. 2011;8(1):13–28. https://doi.org/10.1038/nrcardio.2010.162.
Article CAS PubMed Google Scholar
Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Wang Y. Catabolic defect of Branched-Chain amino acids promotes heart failure. Circulation. 2016;133(21):2038–49. https://doi.org/10.1161/CIRCULATIONAHA.115.020226.
Article CAS PubMed PubMed Central Google Scholar
Wang W, Zhang F, Xia Y, Zhao S, Yan W, Wang H, Lee Y, Li C, Zhang L, Lian K, Gao E, Cheng H, Tao L. Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol. 2016;311(5):H1160–9. https://doi.org/10.1152/ajpheart.00114.2016.
Hyyti OM, Ledee D, Ning XH, Ge M, Portman MA. Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice. Am J Physiol Heart Circ Physiol. 2010;299(3):H868–75. https://doi.org/10.1152/ajpheart.00931.2009.
Article CAS PubMed PubMed Central Google Scholar
Lopaschuk GD, Dyck JRB. Ketones and the cardiovascular system. Nat Cardiovasc Res. 2023;2:425–37. https://doi.org/10.1038/s44161-023-00259-1.
Article CAS PubMed Google Scholar
Terman A, Brunk UT. Myocyte aging and mitochondrial turnover. Exp Gerontol. 2004;39(5):701–5. https://doi.org/10.1016/j.exger.2004.01.005.
Article CAS PubMed Google Scholar
Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB Journal: Official Publication Federation Am Soc Experimental Biology. 2005;19(3):419–21. https://doi.org/10.1096/fj.04-2622fje.
Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94(3):909–50. https://doi.org/10.1152/physrev.00026.2013.
Article CAS PubMed PubMed Central Google Scholar
Qian L, Zhu Y, Deng C, Liang Z, Chen J, Chen Y, Wang X, Liu Y, Tian Y, Yang Y. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases. Signal Transduct Target Therapy. 2024;9(1):50. https://doi.org/10.1038/s41392-024-01756-w.
Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW, Wiesner RJ. Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during aging. Cell Metabol. 2015;21(5):667–77. https://doi.org/10.1016/j.cmet.2015.04.005.
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429(6990):417–23. https://doi.org/10.1038/nature02517.
Comments (0)