The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology

Patterson C World alzheimer report 2018. The state of the art of dementia research: New Frontiers; 2018. https://www.alzint.org/resource/world-alzheimer-report-2018/.

Bartus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science. 1982;217:408–14.

Article  PubMed  CAS  Google Scholar 

Davies P, Maloney A. Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet. 1976;2:1403.

Article  PubMed  CAS  Google Scholar 

Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer’s disease and senile dementia: loss of neurons in the basal forebrain. Science. 1982;215:1237–9.

Article  PubMed  CAS  Google Scholar 

Everitt BJ, Robbins TW. Central cholinergic systems and cognition. Annu Rev Psychol. 1997;48:649–84.

Article  PubMed  CAS  Google Scholar 

Perry E, Walker M, Grace J, Perry R. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci. 1999;22:273–80.

Article  PubMed  CAS  Google Scholar 

Suzuki M, Larkum ME. General anesthesia decouples cortical pyramidal neurons. Cell. 2020;180:666–76.e13.

Article  PubMed  CAS  Google Scholar 

Pal D, Dean JG, Liu T, Li D, Watson CJ, Hudetz AG, et al. Differential role of prefrontal and parietal cortices in controlling level of consciousness. Curr Biol. 2018;28:2145–52.e5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Koukouli F, Rooy M, Changeux J-P, Maskos U. Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing. Proc Natl Acad Sci. 2016;113:14823–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Koukouli F, Changeux JP. Do nicotinic receptors modulate high-order cognitive processing? Trends Neurosci. 2020;43:550–64.

Article  PubMed  CAS  Google Scholar 

Birks J. Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006. https://doi.org/10.1002/14651858.CD005593.

Article  PubMed  PubMed Central  Google Scholar 

Hampel H, Mesulam M-M, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain. 2018;141:1917–33.

Article  PubMed  PubMed Central  Google Scholar 

Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med. 2016;8:595–608.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Long JM, Holtzman DM. Alzheimer disease: an update on pathobiology and treatment strategies. Cell. 2019;179:312–39.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu KY, Howard R. Can we learn lessons from the FDA’s approval of aducanumab? Nat Rev Neurol. 2021. https://doi.org/10.1038/s41582-021-00557-x.

Article  PubMed  Google Scholar 

Alzheimer_Association. Aducanumab discontinued as an Alzheimer’s treatment. https://www.alz.org/alzheimers-dementia/treatments/aducanumab:2024.

van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in early Alzheimer’s disease. N Engl J Med. 2023;388:9–21.

Article  PubMed  Google Scholar 

Whitehouse P, Martino A, Antuono P, Lowenstein P, Coyle J, Price D, et al. Nicotinic acetylcholine binding sites in Alzheimer’s disease. Brain Res. 1986;371:146–51.

Article  PubMed  CAS  Google Scholar 

Nordberg A, Winblad B. Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett. 1986;72:115–20.

Article  PubMed  CAS  Google Scholar 

Kadir A, Almkvist O, Wall A, Långström B, Nordberg A. PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer’s disease. Psychopharmacology. 2006;188:509–20.

Article  PubMed  CAS  Google Scholar 

Sabri O, Meyer PM, Gräf S, Hesse S, Wilke S, Becker GA, et al. Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer’s dementia. Brain. 2018;141:1840–54.

Article  PubMed  PubMed Central  Google Scholar 

Lombardo S, Maskos U. Role of the nicotinic acetylcholine receptor in Alzheimer’s disease pathology and treatment. Neuropharmacology. 2015;96:255–62.

Article  PubMed  CAS  Google Scholar 

Zoli M, Lena C, Picciotto MR, Changeux JP. Identification of four classes of brain nicotinic receptors using beta2 mutant mice. J Neurosci. 1998;18:4461–72.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Picciotto MR, Zoli M, Lena C, Bessis A, Lallemand Y, Le Novere N, et al. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995;374:65–7.

Article  PubMed  CAS  Google Scholar 

George AA, Vieira JM, Xavier-Jackson C, Gee MT, Cirrito JR, Bimonte-Nelson HA, et al. Implications of oligomeric amyloid-beta (oAβ42) signaling through α7β2-nicotinic acetylcholine receptors (nAChRs) on basal forebrain cholinergic neuronal intrinsic excitability and cognitive decline. J Neurosci. 2021;41:555–75.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Corringer PJ, Le Novere N, Changeux JP. Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol. 2000;40:431–58.

Article  PubMed  CAS  Google Scholar 

Parri HR, Hernandez CM, Dineley KT. Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer’s disease. Biochem Pharmacol. 2011;82:931–42.

Article  PubMed  CAS  Google Scholar 

Wang HY, Lee DH, Davis CB, Shank RP. Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem. 2000;75:1155–61.

Article  PubMed  CAS  Google Scholar 

Cecon E, Dam J, Luka M, Gautier C, Chollet AM, Delagrange P, et al. Quantitative assessment of oligomeric amyloid β peptide binding to α 7 nicotinic receptor. Br J Pharmacol. 2019;176:3475–88.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Koukouli F, Maskos U. The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system. Biochem Pharmacol. 2015;97:378–87.

Article  PubMed  CAS  Google Scholar 

Wang H-Y, Lee DHS, D’Andrea MR, Peterson PA, Shank RP, Reitz AB. β-Amyloid1–42 binds to α7 nicotinic acetylcholine receptor with high affinity. J Biol Chem. 2000;275:5626–32.

Article  PubMed  CAS  Google Scholar 

Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF. Deletion of the 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer’s disease. J Neurosci. 2009;29:8805–15.

Article  PubMed 

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