Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment

Kodama T, Lai YY, Siegel JM. Enhancement of acetylcholine release during REM sleep in the caudomedial medulla as measured by in vivo microdialysis. Brain Res. 1992;580:348–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vazquez J, Baghdoyan HA. Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking. Am J Physiol Regul Integr Comp Physiol. 2001;280:R598–R601.

Article  CAS  PubMed  Google Scholar 

Platt B, Riedel G. The cholinergic system, EEG and sleep. Behav Brain Res. 2011;221:499–504.

Article  CAS  PubMed  Google Scholar 

Mesulam MM, Mufson EJ, Wainer BH, Levey AI. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience. 1983;10:1185–201.

Article  CAS  PubMed  Google Scholar 

Mesulam MM, Van Hoesen GW. Acetylcholinesterase-rich projections from the basal forebrain of the rhesus monkey to neocortex. Brain Res. 1976;109:152–7.

Article  CAS  PubMed  Google Scholar 

Buzsaki G, Bickford RG, Ponomareff G, Thal LJ, Mandel R, Gage FH. Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci. 1988;8:4007–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riekkinen P, Sirviö J, Riekkinen P. Relationship between the cortical choline acetyltransferase content and EEG delta-power. Neurosci Res. 1990;8:12–20.

Article  CAS  PubMed  Google Scholar 

Shi YF, Han Y, Su YT, Yang JH, Yu YQ. Silencing of cholinergic basal forebrain neurons using archaerhodopsin prolongs slow-wave sleep in mice. PLoS ONE. 2015;10:e0130130.

Article  PubMed  PubMed Central  Google Scholar 

Chen L, Yin D, Wang TX, Guo W, Dong H, Xu Q, et al. Basal forebrain cholinergic neurons primarily contribute to inhibition of electroencephalogram delta activity, rather than inducing behavioral wakefulness in mice. Neuropsychopharmacology. 2016;41:2133–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bassant MH, Apartis E, Jazat-Poindessous FR, Wiley RG, Lamour YA. Selective immunolesion of the basal forebrain cholinergic neurons: effects on hippocampal activity during sleep and wakefulness in the rat. Neurodegeneration. 1995;4:61–70.

Article  CAS  PubMed  Google Scholar 

Montplaisir J, Petit D, Lorrain D, Gauthier S, Nielsen T. Sleep in Alzheimer’s disease: Further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. Sleep. 1995;18:145–8.

Article  CAS  PubMed  Google Scholar 

Floyd JA, Janisse JJ, Jenuwine ES, Ager JW. Changes in REM-sleep percentage over the adult lifespan. Sleep. 2007;30:829–36.

Article  PubMed  PubMed Central  Google Scholar 

Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep. 2004;27:1255–73.

Article  PubMed  Google Scholar 

Mesulam M, Shaw P, Mash D, Weintraub S. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol. 2004;55:815–28.

Article  CAS  PubMed  Google Scholar 

Schmitz TW, Nathan Spreng R. Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology. Nat Commun. 2016;7:13249.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmitz TW, Mur M, Aghourian M, Bedard MA, Spreng RN. Longitudinal Alzheimer’s degeneration reflects the spatial topography of cholinergic basal forebrain projections. Cell Rep. 2018;24:38–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-Cabello S, Kronbichler M, van Dijk KRA, Goodman JA, Nathan Spreng R, Schmitz TW. Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration. Brain. 2020;143:993–1009.

Article  PubMed  PubMed Central  Google Scholar 

Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, et al. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer’s disease pathology. Sci Transl Med. 2012;4:150ra122.

Article  PubMed  PubMed Central  Google Scholar 

Holth JK, Mahan TE, Robinson GO, Rocha A, Holtzman DM. Altered sleep and EEG power in the P301S Tau transgenic mouse model. Ann Clin Transl Neurol. 2017;4:180–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Erum J, Van Dam D, Sheorajpanday R, De Deyn PP. Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits. Behav Brain Res. 2019;373:112089.

Article  PubMed  Google Scholar 

Zhang Y, Ren R, Yang L, Zhang H, Shi Y, Okhravi HR, et al. Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings. Transl Psychiatry. 2022;12:136.

Article  PubMed  PubMed Central  Google Scholar 

Brayet P, Petit D, Frauscher B, Gagnon J-F, Gosselin N, et al. Quantitative EEG of Rapid-Eye-Movement Sleep. Clin EEG Neurosci. 2016;47:134–41.

D’Rozario AL, Chapman JL, Phillips CL, Palmer JR, Hoyos CM, Mowszowski L, et al. Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis. Sleep Med Rev. 2020;52:101308.

Article  PubMed  Google Scholar 

André C, Martineau-Dussault MÈ, Daneault V, Blais H, Frenette S, Lorrain D, et al. REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals. Alzheimers Res Ther. 2023;15:151.

Article  PubMed  PubMed Central  Google Scholar 

Arvidsson U, Riedl M, Elde R, Meister B. Vesicular acetylcholine transporter (VAChT) protein: A novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. J Comp Neurol. 1997;378:454–67.

Article  CAS  PubMed  Google Scholar 

Prior C, Marshall IG, Parsons SM. The pharmacology of vesamicol: An inhibitor of the vesicular acetylcholine transporter. Gen Pharmacol. 1992;23:1017–22.

Article  CAS  PubMed  Google Scholar 

Mulholland GK, Wieland DM, Kilbourn MR, Frey KA, Sherman PS, Carey JE, et al. [18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses. Synapse. 1998;30:263–74.

Article  CAS  PubMed  Google Scholar 

Kilbourn MR, Hockley B, Lee L, Sherman P, Quesada C, Frey KA, et al. Positron emission tomography imaging of (2R,3R)-5-[18F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter. Nucl Med Biol. 2009;36:489–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cyr M, Parent MJ, Mechawar N, Rosa-Neto P, Soucy JP, Aliaga A, et al. PET imaging with [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nucl Med Biol. 2014;41:96–101.

Article  CAS  PubMed  Google Scholar 

Parent M, Bedard MA, Aliaga A, Soucy JP, Landry St-Pierre E, Cyr M, et al. PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV). Neuroimage. 2012;62:555–61.

Article  CAS  PubMed  Google Scholar 

Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, et al. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOB

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