Dynamic immune and metabolic dysregulation in women with post-traumatic stress disorder: Longitudinal transcriptomic insights following sexual assault

White J, Pearce J, Morrison S, Dunstan F, Bisson JI, Fone DL. Risk of post-traumatic stress disorder following traumatic events in a community sample. Epidemiol Psychiatr Sci. 2014;24:249–57.

Article  PubMed  PubMed Central  Google Scholar 

Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593–602.

Article  PubMed  Google Scholar 

American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Washington, DC: American Psychiatric Association; 2013.

Book  Google Scholar 

Costa RR Brasil tem cerca de 822 mil casos de estupro a cada ano, dois por minuto. Instituto de Pesquisa Econômica Aplicada (IPEA). 2023. Available from: https://www.ipea.gov.br/portal/categorias/45-todas-as-noticias/noticias/13541-brasil-tem-cerca-de-822-mil-casos-de-estupro-a-cada-ano-dois-por-minuto.

O Globo. Uma mulher sofre violência sexual no país a cada 46 minutos, diz estudo; vítimas mais frequentes têm de 10 a 14 anos. 2024 Jun 18. Available from: https://oglobo.globo.com/brasil/noticia/2024/06/18/uma-mulher-e-estuprada-no-pais-a-cada-46-minutos-indica-atlas-da-violencia-vitimas-mais-frequentes-tem-de-10-a-14-anos.ghtml.

Agência Brasil. Pesquisa aponta alta nos números de violência contra mulheres no país. 2025 Mar. Available from: https://agenciabrasil.ebc.com.br/radioagencia-nacional/direitos-humanos/audio/2025-03/pesquisa-aponta-alta-nos-numeros-de-violencia-contra-mulheres-no-pais.

Tolin DF, Foa EB. Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research. Psychol Bull. 2006;132:959–92.

Article  PubMed  Google Scholar 

Kimerling R, Allen MC, Duncan LE. Chromosomes to social contexts: sex and gender differences in PTSD. Curr Psychiatry Rep. 2018;20:114.

Article  PubMed  Google Scholar 

Krupnick JL. Gender differences in trauma types and themes in veterans with posttraumatic stress disorder. J Loss Trauma. 2017;22:514–25.

Article  Google Scholar 

Sareen J. Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. Can J Psychiatry. 2014;59:460–7.

Article  PubMed  PubMed Central  Google Scholar 

Du J, Diao H, Zhou X, Zhang C, Chen Y, Gao Y, et al. Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention. Med Rev. 2021;2:219–43.

Article  Google Scholar 

Koenen KC, Nugent NR, Amstadter AB. Gene-environment interaction in posttraumatic stress disorder. Eur Arch Psychiatry Clin Neurosci. 2008;258:82–96.

Article  PubMed  PubMed Central  Google Scholar 

Mehta D, Binder EB. Gene × environment vulnerability factors for PTSD: the HPA-axis. Neuropharmacology. 2012;62:654–62.

Article  CAS  PubMed  Google Scholar 

Kremen WS, Koenen KC, Afari N, Lyons MJ. Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae. Neuropharmacology. 2012;62:647–53.

Article  CAS  PubMed  Google Scholar 

Wolf EJ, Miller MW, Sullivan DR, Amstadter AB, Mitchell KS, Goldberg J, et al. A classical twin study of PTSD symptoms and resilience: evidence for a single spectrum of vulnerability to traumatic stress. Depress Anxiety. 2018;35:132–9.

Article  CAS  PubMed  Google Scholar 

Koenen KC, Fu QJ, Ertel K, Lyons MJ, Eisen SA, True WR, et al. Common genetic liability to major depression and posttraumatic stress disorder in men. J Affect Disord. 2008;105:109–15.

Article  PubMed  Google Scholar 

Tambs K, Czajkowsky N, Røysamb E, Neale MC, Reichborn-Kjennerud T, Aggen SH, et al. Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders. Br J Psychiatry. 2009;195:301–7.

Article  PubMed  PubMed Central  Google Scholar 

True WR, Rice J, Eisen SA, Heath AC, Goldberg J, Lyons MJ, et al. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch Gen Psychiatry. 1993;50:257–64.

Article  CAS  PubMed  Google Scholar 

Stein MB, Jang KL, Taylor S, Vernon PA, Livesley WJ. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am J Psychiatry. 2002;159:1675–81.

Article  PubMed  Google Scholar 

Olff M. Sex and gender differences in post-traumatic stress disorder: an update. Eur J Psychotraumatol. 2017;8:1351204.

Article  PubMed Central  Google Scholar 

Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, et al. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nat Genet. 2024;56:792–808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girgenti MJ, Wang J, Ji D, Cruz DA, Traumatic Stress Brain Research Group, Stein MB, et al. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nat Neurosci. 2021;24:24–33.

Article  CAS  PubMed  Google Scholar 

Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, et al. Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21.31 locus, in PTSD stress response. Am J Psychiatry. 2023;180:739–54.

Article  PubMed  PubMed Central  Google Scholar 

Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, et al. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: a pilot study. Psychoneuroendocrinology. 2015;51:472–94.

Article  CAS  PubMed  Google Scholar 

Dahrendorff J, Wani AH, Keller TE, Armstrong D, Qu A, Wildman DE, et al. Analysis of posttraumatic stress disorder gene expression profiles in a prospective, community-based cohort. Hum Biol. 2023;95:33–47. https://doi.org/10.1353/hub.2017.a935047.

Kuan PF, Yang X, Ren X, Che C, Waszczuk MA, Kotov R, et al. Mapping the transcriptomics landscape of post-traumatic stress disorder symptom dimensions in World Trade Center responders. Transl Psychiatry. 2021;11:1–9.

Article  Google Scholar 

Katrinli S, Oliveira NCS, Felger JC, Michopoulos V, Smith AK. The role of the immune system in posttraumatic stress disorder. Transl Psychiatry. 2022;12:313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Logue MW, Smith AK, Baldwin C, Wolf EJ, Guffanti G, Ratanatharathorn A, et al. An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress. Psychoneuroendocrinology. 2015;57:1–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gill JM, Saligan L, Woods S, Page G. PTSD is associated with an excess of inflammatory immune activities. Perspect Psychiatr Care. 2009;45:262–77.

Article  PubMed  Google Scholar 

Kmita H, Pinna G, Lushchak VI. Potential oxidative stress-related targets of mitochondria-focused therapy of PTSD. Front Physiol. 2023;14:1266575 https://www.frontiersin.org/articles/10.3389/fphys.2023.1266575/full Available from:

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Li H, Hu X, Benedek DM, Fullerton CS, Forsten RD, et al. Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD. Transl Psychiatry. 2015;5:e580.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su YA, Wu J, Zhang L, Zhang Q, Su DM, He P, et al. Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder revealed by human mitochondria-focused cDNA microarrays. Int J Biol Sci. 2008;4:223–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Panzenhagen AC, Alves-Teixeira A, Wissmann MS, Girardi CS, Santos L, Silveira AK, et al. Peripheral blood as a tool to determine gene expression patterns in patients with psychiatric, neurological and other common disorders: a systematic review and meta-analysis protocol. medRxiv. 2019. [Preprint]. Available from: https://www.medrxiv.org/content/10.1101/19007633v1.

Hernandez LM, Kim M, Hoftman GD, Haney JR, Ubieta L, de la T, Pasaniuc B, et al. Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders. Biol Psychiatry. 2021;89:54–64.

Article  CAS  PubMed  Google Scholar 

Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry. 2005;10:425–36.

Article  PubMed 

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