Regulatory Networks Driving the Specification, Differentiation, and Diversification of Neurons in the Mouse Inner Ear

Maklad A, Fritzsch B (2003) Development of vestibular afferent projections into the hindbrain and their central targets. Brain Res Bull 60:497–510. https://doi.org/10.1016/s0361-9230(03)00054-6

Article  PubMed  PubMed Central  Google Scholar 

Pyott SJ, Pavlinkova G, Yamoah EN et al (2024) Harmony in the molecular orchestra of hearing: developmental mechanisms from the ear to the brain. Annu Rev Neurosci 47:1–20. https://doi.org/10.1146/annurev-neuro-081423-093942

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yang T, Kersigo J, Jahan I et al (2011) The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti. Hear Res 278:21–33. https://doi.org/10.1016/j.heares.2011.03.002

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thawani A, Maunsell HR, Zhang H et al (2023) The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border. Development. https://doi.org/10.1242/dev.202047

Article  PubMed  PubMed Central  Google Scholar 

Urness LD, Paxton CN, Wang X et al (2010) FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol 340:595–604. https://doi.org/10.1016/j.ydbio.2010.02.016

Article  PubMed  PubMed Central  CAS  Google Scholar 

Urness LD, Wang X, Li C et al (2020) Slc26a9(P2ACre): a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia. Development 147. https://doi.org/10.1242/dev.191015

Ranganathan R, Sari F, Wang SX et al (2025) Targets of the transcription factor Six1 identify previously unreported candidate deafness genes. Development. https://doi.org/10.1242/dev.204533

Article  PubMed  PubMed Central  Google Scholar 

Xu J, Li J, Zhang T et al (2021) Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm. Proc Natl Acad Sci USA. https://doi.org/10.1073/pnas.2025196118

Article  PubMed  PubMed Central  Google Scholar 

Dvorakova M, Macova I, Bohuslavova R et al (2020) Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2. Dev Biol 457:43–56. https://doi.org/10.1016/j.ydbio.2019.09.003

Article  PubMed  CAS  Google Scholar 

Ma Q, Anderson DJ, Fritzsch B (2000) Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. J Assoc Res Otolaryngol 1:129–143. https://doi.org/10.1007/s101620010017

Article  PubMed  PubMed Central  CAS  Google Scholar 

Matei V, Pauley S, Kaing S et al (2005) Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn 234:633–650. https://doi.org/10.1002/dvdy.20551

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fariñas I, Jones KR, Tessarollo L et al (2001) Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci 21:6170–6180. https://doi.org/10.1523/jneurosci.21-16-06170.2001

Article  PubMed  PubMed Central  Google Scholar 

Silos-Santiago I, Fagan AM, Garber M et al (1997) Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors. Eur J Neurosci 9:2045–2056. https://doi.org/10.1111/j.1460-9568.1997.tb01372.x

Article  PubMed  CAS  Google Scholar 

Kersigo J, Fritzsch B (2015) Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation. Front Aging Neurosci 7:33. https://doi.org/10.3389/fnagi.2015.00033

Article  PubMed  PubMed Central  Google Scholar 

Filova I, Bohuslavova R, Tavakoli M et al (2022) Early deletion of Neurod1 alters neuronal lineage potential and diminishes neurogenesis in the inner ear. Front Cell Dev Biol 10:845461. https://doi.org/10.3389/fcell.2022.845461

Article  PubMed  PubMed Central  Google Scholar 

Filova I, Pysanenko K, Tavakoli M et al (2022) ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proc Natl Acad Sci USA 119:e2207433119. https://doi.org/10.1073/pnas.2207433119

Article  PubMed  PubMed Central  Google Scholar 

Sun Y, Wang L, Zhu T et al (2022) Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep 38:110542. https://doi.org/10.1016/j.celrep.2022.110542

Article  PubMed  CAS  Google Scholar 

Petitpré C, Faure L, Uhl P et al (2022) Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Nat Commun 13:3878. https://doi.org/10.1038/s41467-022-31580-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sanders TR, Kelley MW (2022) Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse. Proc Natl Acad Sci U S A 119:e2203935119

Article  PubMed  PubMed Central  CAS  Google Scholar 

Matern MS, Durruthy-Durruthy R, Birol O et al (2023) Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Rep 42:112545. https://doi.org/10.1016/j.celrep.2023.112545

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lysakowski A (2020) Anatomy and microstructural organization of vestibular hair cells. In: Fritzsch B (ed) The senses: a comprehensive reference. Elsevier, pp 173–184

Petitpre C, Wu H, Sharma A et al (2018) Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nat Commun 9:3691. https://doi.org/10.1038/s41467-018-06033-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shrestha BR, Chia C, Wu L et al (2018) Sensory neuron diversity in the inner ear is shaped by activity. Cell 174(1229–1246):e1217. https://doi.org/10.1016/j.cell.2018.07.007

Article  CAS  Google Scholar 

Duncan JS, Fritzsch B (2013) Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS ONE 8:e62046. https://doi.org/10.1371/journal.pone.0062046

Article  PubMed  PubMed Central  CAS  Google Scholar 

Appler JM, Lu CC, Druckenbrod NR et al (2013) Gata3 is a critical regulator of cochlear wiring. J Neurosci 33:3679–3691

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chizhikov VV, Iskusnykh IY, Fattakhov N et al (2021) Lmx1a and Lmx1b are redundantly required for the development of multiple components of the mammalian auditory system. Neuroscience 452:247–264. https://doi.org/10.1016/j.neuroscience.2020.11.013

Article  PubMed  CAS  Google Scholar 

Bouchard M, de Caprona D, Busslinger M et al (2010) Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol 10:89. https://doi.org/10.1186/1471-213x-10-89

Article  PubMed  PubMed Central  Google Scholar 

Bok J, Zenczak C, Hwang CH et al (2013) Auditory ganglion source of sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells. Proc Natl Acad Sci U S A 110:13869–13874

Article  PubMed  PubMed Central  CAS  Google Scholar 

Riccomagno MM, Martinu L, Mulheisen M et al (2002) Specification of the mammalian cochlea is dependent on sonic hedgehog. Genes Dev 16:2365–2378

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