Borchert GA, Kandel H, Watson SL (2024) Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis. Graefes Arch Clin Exp Ophthalmol 262(6):1683–1692
D’Oria F, Palazón A, Alio JL (2021) Corneal collagen cross-linking epithelium-on vs. epithelium-off: a systematic review and meta-analysis. Eye Vis (Lond) 8(1):34
Article PubMed PubMed Central Google Scholar
Panos GD, Kozeis N, Balidis M, Moschos MM, Hafezi F (2017) Collagen cross-linking for paediatric keratoconus. Open Ophthalmol J 31(11):211–216
Roszkowska AM, Oliverio GW, Hydzik-Sajak K, De Crescenzo M, Aragona P (2023) Five-year results of iontophoresis-assisted transepithelial corneal cross-linking for keratoconus. Int Ophthalmol 43(10):3601–3607
Article PubMed PubMed Central Google Scholar
Lombardo M, Giannini D, Lombardo G, Serrao S (2017) Randomized controlled trial comparing transepithelial corneal cross-linking using iontophoresis with the Dresden protocol in progressive keratoconus. Ophthalmology 124(6):804–812
Bikbova G, Bikbov M (2016) Standard corneal collagen crosslinking versus transepithelial iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized control trial. Acta Ophthalmol 94(7):e600–e606
Article CAS PubMed PubMed Central Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 29(372):n71
Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 18(343):d5928
Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560
Article PubMed PubMed Central Google Scholar
Buzzonetti L, Petrocelli G, Valente P, Iarossi G, Ardia R, Petroni S et al (2019) Iontophoretic transepithelial collagen cross-linking versus epithelium-off collagen cross-linking in pediatric patients: 3-year follow-up. Cornea 38(7):859–863
Vinciguerra P, Randleman JB, Romano V, Legrottaglie EF, Rosetta P, Camesasca FI et al (2016) Transepithelial iontophoresis corneal collagen cross-linking for progressive keratoconus: initial clinical outcomes. J Refract Surg 30(11):746–753
Bouheraoua N, Jouve L, El Sanharawi M, Sandali O, Temstet C, Loriaut P et al (2014) Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus. Invest Ophthalmol Vis Sci 55(11):7601–7609
Alqudah N, Alqudah A, Alshamarti S, Shannak Z (2025) Evaluating the efficacy and safety of iontophoresis-assisted corneal cross-linking compared to standard CXL in the treatment of keratoconus. Indian J Ophthalmol 73(7):953–958
Article PubMed PubMed Central Google Scholar
Atia R, Jouve L, Sandali O, Laroche L, Borderie V, Bouheraoua N (2017) Early epithelial remodeling after standard and iontophoresis-assisted corneal cross-linking as evaluated by spectral-domain optical coherence tomography. J Refract Surg 34(8):551–558
Jia HZ, Peng XJ (2018) Efficacy of iontophoresis-assisted epithelium-on corneal cross-linking for keratoconus. Int J Ophthalmol 11(4):687–694
PubMed PubMed Central Google Scholar
Jouve L, Borderie V, Sandali O, Temstet C, Basli E, Laroche L et al (2017) Conventional and iontophoresis corneal cross-linking for keratoconus: efficacy and assessment by optical coherence tomography and confocal microscopy. Cornea 36(2):153–162
Lombardo M, Serrao S, Raffa P, Rosati M, Lombardo G (2016) Novel technique of transepithelial corneal cross-linking using iontophoresis in progressive keratoconus. J Ophthalmol 15(2016):7472542
Lombardo M, Serrao S, Lombardo G, Schiano-Lomoriello D (2018) Two-year outcomes of a randomized controlled trial of transepithelial corneal crosslinking with iontophoresis for keratoconus. J Cataract Refract Surg 45(7):992–1000
Cantemir A, Alexa AI, Anton N, Ciuntu RE, Danielescu C, Chiselita D et al (2016) Evaluation of iontophoretic collagen cross-linking for early stage of progressive keratoconus compared to standard cross-linking: a non-inferiority study. Ophthalmol Ther 6(1):147–160
Article PubMed PubMed Central Google Scholar
Cantemir A, Alexa AI, Galan BG, Anton N, Ciuntu RE, Danielescu C et al (2018) Iontophoretic collagen cross‐linking versus epithelium‐off collagen cross‐linking for early stage of progressive keratoconus – 3 years follow‐up study. Acta Ophthalmol 95(7):e649–e655
Article CAS PubMed Google Scholar
Rossi S, Santamaria C, Boccia R, De Rosa L, D’Alterio FM, Simonelli F et al (2017) Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques. Int Ophthalmol 38(6):2585–2592
Gustafsson I, Bergström A, Cardiakides A, Ivarsen A, Hjortdal JØ (2021) The interday repeatability of parameters for the assessment of progressive disease in subjects with less advanced keratoconus. Am J Ophthalmol 225:38–46. https://doi.org/10.1016/j.ajo.2020.12.028
Seiler TG, Mueller M, Mendes Baiao T (2022) Repeatability and comparison of corneal tomography in mild to severe keratoconus between the anterior segment OCT MS-39 and Pentacam HR. J Refract Surg (Thorofare, NJ : 1995) 38(4):250–255. https://doi.org/10.3928/1081597X-20220114-02
Miao W, Zhou D, Li C, Chen L, Guan M, Peng Y et al (2021) Dental developmental stage affects the treatment outcome of maxillary protraction in skeletal Class III children: A systematic review and meta-analysis. Australasian Orthod J 37(1):37–49
Gustafsson I, Ivarsen A, Hjortdal J (2023) Early findings in a prospective randomised study on three cross-linking treatment protocols: interruption of the iontophoresis treatment protocol. BMJ Open Ophthalmol 8(1):e001406. https://doi.org/10.1136/bmjophth-2023-001406
Article PubMed PubMed Central Google Scholar
Gustafsson I, Olafsdottir T, Neumann O, Bizios D, Ivarsen A, Hjortdal JØ (2025) A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae. Acta Ophthalmol. https://doi.org/10.1111/aos.17551
Article PubMed PubMed Central Google Scholar
Borchert GA, Watson SL, Kandel H (2022) Oxygen in corneal collagen crosslinking to treat keratoconus: a systematic review and meta-analysis. Asia Pac J Ophthalmol 11(5):453–459. https://doi.org/10.1097/APO.0000000000000555
Seiler T, Hafezi F (2006) Corneal cross-linking-induced stromal demarcation line. Cornea 25(9):1057–1059. https://doi.org/10.1097/01.ico.0000225720.38748.58
Wen D, Li Q, Song B, Tu R, Wang Q, O’Brart DPS et al (2018) Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: a meta-analysis. Invest Ophthalmol Vis Sci 59(10):3920–3931
Article CAS PubMed Google Scholar
Ferraro V, Santoru F, Barone G, Rosetta P (2024) Outcomes of iontophoresis cross-linking in asymmetric keratoconus: a retrospective analysis of high visual acuity eyes under 25 years old. Clin Ophthalmol 18(22):3399–3403
Article CAS PubMed PubMed Central Google Scholar
Jia HZ, Pang X, Fan ZJ, Peng XJ (2017) Iontophoresis-assisted versus standard corneal crosslinking for progressive keratoconus. Ann Eye Sci 2(2):9–9
Comments (0)