Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y et al. Heart disease and stroke statistics-2022 update: a report from the american heart association. Circulation. 2022;145(8):e153-e639. https://doi.org/10.1161/CIR.0000000000001074.

Schäfer A, König T, Bauersachs J, Akin M. Novel therapeutic strategies to reduce reperfusion injury after acute myocardial infarction. Curr Probl Cardiol. 2022;47:101398.

Article  PubMed  Google Scholar 

Saito Y, Oyama K, Tsujita K, Yasuda S, Kobayashi Y. Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond. J Cardiol. 2023;81:168–78.

Article  PubMed  Google Scholar 

Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS. Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metab. 2024;35:219–34.

Article  CAS  PubMed  Google Scholar 

Yang X, Huang Y, Tang D, Yue L. Identification of key genes associated with acute myocardial infarction using WGCNA and two-sample mendelian randomization study. PLoS One. 2024;19:e0305532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Zhong N, Zhu X, et al. Identification of important genes associated with acute myocardial infarction using multiple cell death patterns. Cell Signal. 2023;112:110921.

Article  CAS  PubMed  Google Scholar 

Palomer X, Salvador JM, Griñán-Ferré C, Barroso E. GADD45A: With or without you. Med Res Rev. 2024;44:1375–403.

Article  CAS  PubMed  Google Scholar 

Humayun A, Fornace AJ Jr. GADD45 in stress signaling, cell cycle control, and apoptosis. Adv Exp Med Biol. 2022;1360:1–22.

Article  CAS  PubMed  Google Scholar 

Chandramouly G. Gadd45 in DNA demethylation and DNA repair. Adv Exp Med Biol. 2022;1360:55–67.

Article  CAS  PubMed  Google Scholar 

Camilleri-Robles C, Serras F, Corominas M. Role of D-GADD45 in JNK-dependent apoptosis and regeneration in drosophila. Genes. 2019;10:378.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhan Y, Huang Q, Deng Z, et al. DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD. J Adv Res. 2025;68:201–14.

Article  CAS  PubMed  Google Scholar 

Su X, Pan J, Bai F, et al. IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways. J Transl Med. 2016;14:283.

Article  PubMed  PubMed Central  Google Scholar 

Lucas A, Mialet-Perez J, Daviaud D, et al. Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling. Cardiovasc Res. 2015;108:254–67.

Article  CAS  PubMed  Google Scholar 

Wan X, Yao B, Ma Y, et al. MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling. Biochem Biophys Res Commun. 2020;530:314–21.

Article  CAS  PubMed  Google Scholar 

Lambert SA, Jolma A, Campitelli LF, et al. The human transcription factors. Cell. 2018;172:650–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ulasov AV, Rosenkranz AA, Sobolev AS. Transcription factors: Time to deliver. J Control Release. 2018;269:24–35.

Article  CAS  PubMed  Google Scholar 

Ding J, Fayyaz AI, Ding Y, Liang D, Luo M. Role of specificity protein 1 (SP1) in cardiovascular diseases: pathological mechanisms and therapeutic potentials. Biomolecules. 2024;14:807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Li R, Qin X, et al. Sp1 plays an important role in vascular calcification both in vivo and in vitro. J Am Heart Assoc. 2018;7:e007555.

Article  PubMed  PubMed Central  Google Scholar 

Zheng H, Wang J, Zheng Y, Hong X, Wang L. Identification of genetic associations between acute myocardial infarction and non-small cell lung cancer. Front Mol Biosci. 2024;11:1502509.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R, Geng HH, Xiao J, et al. miR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1. Scientific reports. 2016;6:29082.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Zhang C, Zhu H, et al. Luteolin modulates SERCA2a via Sp1 upregulation to attenuate myocardial ischemia/reperfusion injury in mice. Sci Rep. 2020;10:15407.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Wang B, Liu X, et al. Sp1 targeted PARP1 inhibition protects cardiomyocytes from myocardial ischemia-reperfusion injury via downregulation of autophagy. Front Cell Dev Biol. 2021;9:621906.

Article  PubMed  PubMed Central  Google Scholar 

Sagris M, Apostolos A. Myocardial ischemia-reperfusion injury: unraveling pathophysiology, clinical manifestations, and emerging prevention strategies. Biomedicines. 2024;12:802.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Welt FGP, Batchelor W, Spears JR, et al. Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement. J Am Coll Cardiol. 2024;83:2196–213.

Article  PubMed  Google Scholar 

Duan D, Fan T, Zhang L, et al. The correlation between cardiac oxidative stress and inflammatory cytokine response following myocardial infarction. Clin Appl Thromb Hemost. 2023;29:10760296231211907.

Article  CAS  PubMed  PubMed Central  Google Scholar 

González-Montero J, Brito R, Gajardo AI, Rodrigo R. Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. World J Cardiol. 2018;10:74–86.

Article  PubMed  PubMed Central  Google Scholar 

Tomandlova M, Parenica J, Lokaj P, et al. Prognostic value of oxidative stress in patients with acute myocardial infarction complicated by cardiogenic shock: a prospective cohort study. Free Radical Bio Med. 2021;174:66–72.

Article  CAS  Google Scholar 

Duan D, Li H, Chai S, et al. The relationship between cardiac oxidative stress, inflammatory cytokine response, cardiac pump function, and prognosis post-myocardial infarction. Sci Rep. 2024;14:8985.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Gong P, Su Y, et al. Angiotensin II type 2 receptor agonist attenuates LPS-induced acute lung injury through modulating THP-1-derived macrophage reprogramming. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:99–108.

Article  CAS  PubMed  Google Scholar 

Sun Y, Wang M, Tan X, Zhang H, Yang S. Identification of oxidative stress-related biomarkers in acute myocardial infarction. Int J Gen Med. 2023;16:4805–18.

Article  PubMed  PubMed Central  Google Scholar 

Shen T, Tai W, Jiang D, et al. GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration. Neuron. 2025;113:2176–95.e10.

Article  CAS  PubMed  PubMed Central