Enriquez-Sarano M, Akins CW, Vahanian A. Mitral regurgitation. Lancet (London, England). 2009;373(9672):1382–94. https://doi.org/10.1016/s0140-6736(09)60692-9.

Article  PubMed  Google Scholar 

Feinberg MS, Schwammenthal E, Shlizerman L, et al. Prognostic significance of mild mitral regurgitation by color Doppler echocardiography in acute myocardial infarction [J]. Am J Cardiol. 2000;86(9):903–7. https://doi.org/10.1016/s0002-9149(00)01119-x.

Article  CAS  PubMed  Google Scholar 

Nishino S, Watanabe N, Kimura T, et al. The course of ischemic mitral regurgitation in acute myocardial infarction after primary percutaneous coronary intervention: from emergency room to long-term follow-up. Circ Cardiovasc Imaging. 2016;9(8):e004841. https://doi.org/10.1161/circimaging.116.004841.

Article  PubMed  Google Scholar 

Zhao Y, Zhu J, Zhang N, et al. GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing [J]. Stem Cells Transl Med. 2020;9(10):1257–71. https://doi.org/10.1002/sctm.20-0005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Luo G, Liu Y, et al. Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity [J]. Cell Death Dis. 2021;12(7):665. https://doi.org/10.1038/s41419-021-03954-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olson KA, Beatty AL, Heidecker B, et al. Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts [J]. Eur Heart J. 2015;36(48):3426–34. https://doi.org/10.1093/eurheartj/ehv385.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018) [J]. Eur Heart J. 2019;40(3):237–69. https://doi.org/10.1093/eurheartj/ehy462.

Article  PubMed  Google Scholar 

Verheggen PW, De Maat MP, Cats VM, et al. Inflammatory status as a main determinant of outcome in patients with unstable angina, independent of coagulation activation and endothelial cell function. Eur Heart J. 1999;20(8):567–74. https://doi.org/10.1053/euhj.1998.1312.

Article  CAS  PubMed  Google Scholar 

Liu Y, Ye T, Chen L, et al. Systemic immune-inflammation index predicts the severity of coronary stenosis in patients with coronary heart disease. Coron Artery Dis. 2021;32(8):715–20. https://doi.org/10.1097/mca.0000000000001037.

Article  PubMed  Google Scholar 

Levine RA, Schwammenthal E. Ischemic mitral regurgitation on the threshold of a solution: from paradoxes to unifying concepts [J]. Circulation. 2005;112(5):745–58. https://doi.org/10.1161/circulationaha.104.486720.

Article  PubMed  Google Scholar 

Chaput M, Handschumacher MD, Tournoux F, et al. Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation [J]. Circulation. 2008;118(8):845–52. https://doi.org/10.1161/circulationaha.107.749440.

Article  PubMed  PubMed Central  Google Scholar 

Silbiger JJ. Novel pathogenetic mechanisms and structural adaptations in ischemic mitral regurgitation. J Am Soc Echocardiogr. 2013;26(10):1107–17. https://doi.org/10.1016/j.echo.2013.07.003.

Article  PubMed  Google Scholar 

Su HH, Liao JM, Wang YH, et al. Exogenous GDF11 attenuates non-canonical TGF-β signaling to protect the heart from acute myocardial ischemia-reperfusion injury [J]. Basic Res Cardiol. 2019;114(3):20. https://doi.org/10.1007/s00395-019-0728-z.

Article  CAS  PubMed  Google Scholar 

Kraler S, Balbi C, Vdovenko D, et al. Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans [J]. Cardiovasc Res. 2023;119(17):2729–42. https://doi.org/10.1093/cvr/cvad153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grande-Allen KJ, Borowski AG, Troughton RW, et al. Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study. J Am Coll Cardiol. 2005;45(1):54–61. https://doi.org/10.1016/j.jacc.2004.06.079.

Article  CAS  PubMed  Google Scholar 

Grande-Allen KJ, Barber JE, Klatka KM, et al. Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation [J]. J Thorac Cardiovasc Surg. 2005;130(3):783–90. https://doi.org/10.1016/j.jtcvs.2005.04.019.

Article  PubMed  Google Scholar 

Kunzelman KS, Quick DW, Cochran RP. Altered collagen concentration in mitral valve leaflets: biochemical and finite element analysis. Ann Thorac Surg. 1998;66(6 Suppl):S198-205. https://doi.org/10.1016/s0003-4975(98)01106-0.

Article  CAS  PubMed  Google Scholar 

Bujak M, Ren G, Kweon HJ, et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling [J]. Circulation. 2007;116(19):2127–38. https://doi.org/10.1161/circulationaha.107.704197.

Article  CAS  PubMed  Google Scholar 

Li Z, Xu H, Liu X, et al. GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3 [J]. Cell Death Dis. 2020;11(10):917. https://doi.org/10.1038/s41419-020-03120-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu B, Chen K, Su W, et al. Correlation between GDF11 serum levels, severity of coronary artery lesions, and the prognosis of patients with ST-segment elevation myocardial infarction [J]. J Cardiovasc Transl Res. 2023;16(4):938–47. https://doi.org/10.1007/s12265-023-10358-w.

Article  PubMed  Google Scholar 

Beaudoin J, Handschumacher MD, Zeng X, et al. Mitral valve enlargement in chronic aortic regurgitation as a compensatory mechanism to prevent functional mitral regurgitation in the dilated left ventricle [J]. J Am Coll Cardiol. 2013;61(17):1809–16. https://doi.org/10.1016/j.jacc.2013.01.064.

Article  PubMed  PubMed Central  Google Scholar 

Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy [J]. Cell. 2013;153(4):828–39. https://doi.org/10.1016/j.cell.2013.04.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinha M, Jang YC, Oh J, et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science (New York, NY). 2014;344(6184):649–52. https://doi.org/10.1126/science.1251152.

Article  CAS  Google Scholar 

Egerman MA, Cadena SM, Gilbert JA, et al. GDF11 increases with age and inhibits skeletal muscle regeneration [J]. Cell Metab. 2015;22(1):164–74. https://doi.org/10.1016/j.cmet.2015.05.010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo H, Guo Y, Liu Y, et al. Growth differentiation factor 11 inhibits adipogenic differentiation by activating TGF-beta/Smad signalling pathway. Cell Prolif. 2019;52(4):e12631. https://doi.org/10.1111/cpr.12631.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Wang Y, Wang Z, et al. Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation [J]. Am J Physiol Gastrointest Liver Physiol. 2018;315(6):G909–20. https://doi.org/10.1152/ajpgi.00159.2018.

Article  CAS  PubMed  Google Scholar 

Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update [J]. J Am Coll Cardiol. 2004;43(10):1731–7. https://doi.org/10.1016/j.jacc.2003.12.047.

Article  CAS  PubMed  Google Scholar 

Onodera K, Sugiura H, Yamada M, et al. Decrease in an anti-ageing