The Role of Testosterone in Atherosclerosis: View From Cell Cultures and Animal Models

Fan J, Watanabe T. Atherosclerosis: known and unknown. Pathol Int. 2022;72:151–60. https://doi.org/10.1111/pin.13202.

Article  PubMed  Google Scholar 

Orekhov AN, Summerhill VI, Khotina VA, Popov MA, Uzokov JK, Sukhorukov VN. Role of mitochondria in the chronification of inflammation: focus on dysfunctional mitophagy and mitochondrial DNA mutations. Gene Expr. 2023;22:329–44. https://doi.org/10.14218/GE.2023.00061.

Article  Google Scholar 

WHO CVDs Fact sheets Cardiovascular Diseases (CVDs). Available online: https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1. Accessed 11 Aug 2024.

Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020;41:2313–30. https://doi.org/10.1093/eurheartj/ehz962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poznyak AV, Kashirskikh DA, Postnov AY, Popov MA, Sukhorukov VN, Orekhov AN. Sialic acid as the potential link between lipid metabolism and inflammation in the pathogenesis of atherosclerosis. Braz J Med Biol Res. 2023;56:e12972. https://doi.org/10.1590/1414-431x2023e12972.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mezentsev A, Bezsonov E, Kashirskikh D, Baig MS, Eid AH, Orekhov A. Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside. Biomedicines. 2021;9:600. https://doi.org/10.3390/biomedicines9060600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poznyak AV, Sukhorukov VN, Popov MA, Chegodaev YS, Postnov AY, Orekhov AN. Mechanisms of the Wnt pathways as a potential target pathway in atherosclerosis. J Lipid Atheroscler. 2023;12:223. https://doi.org/10.12997/jla.2023.12.3.223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikiforov NG, Kirichenko TV, Kubekina MV, Chegodaev YS, Zhuravlev AD, Ilchuk LA, et al. Macrophages derived from LPS-stimulated monocytes from individuals with subclinical atherosclerosis were characterized by increased pro-inflammatory activity. Cytokine. 2023;172:156411. https://doi.org/10.1016/j.cyto.2023.156411.

Article  CAS  PubMed  Google Scholar 

Gisterå A, Hansson GK. The immunology of atherosclerosis. Nat Rev Nephrol. 2017;13:368–80. https://doi.org/10.1038/nrneph.2017.51.

Article  CAS  PubMed  Google Scholar 

Muhammad K, Ayoub MA, Iratni R. Vascular inflammation in cardiovascular disease: is immune system protective or bystander? CPD. 2021;27:2141–50. https://doi.org/10.2174/1381612827666210118121952.

Article  CAS  Google Scholar 

Batty M, Bennett MR, Yu E. The role of oxidative stress in atherosclerosis. Cells. 2022;11:3843. https://doi.org/10.3390/cells11233843.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petrucci G, Rizzi A, Hatem D, Tosti G, Rocca B, Pitocco D. Role of oxidative stress in the pathogenesis of atherothrombotic diseases. Antioxidants. 2022;11:1408. https://doi.org/10.3390/antiox11071408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poznyak AV, Orekhova VA, Sukhorukov VN, Khotina VA, Popov MA, Orekhov AN. Atheroprotective aspects of heat shock proteins. Int J Mol Sci. 2023;24:11750. https://doi.org/10.3390/ijms241411750.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yurdagul A, Doran AC, Cai B, Fredman G, Tabas IA. Mechanisms and consequences of defective efferocytosis in atherosclerosis. Front Cardiovasc Med. 2018;4:86. https://doi.org/10.3389/fcvm.2017.00086.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leszczynska A, Murphy JM. Vascular calcification: is it rather a stem/progenitor cells driven phenomenon? Front Bioeng Biotechnol. 2018;6:10. https://doi.org/10.3389/fbioe.2018.00010.

Article  PubMed  PubMed Central  Google Scholar 

Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, et al. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature Mater. 2016;15:335–43. https://doi.org/10.1038/nmat4519.

Article  CAS  Google Scholar 

Libby P. The changing landscape of atherosclerosis. Nature. 2021;592:524–33. https://doi.org/10.1038/s41586-021-03392-8.

Article  CAS  PubMed  Google Scholar 

Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, et al. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. J Steroid Biochem Mol Biol. 2019;194:105439. https://doi.org/10.1016/j.jsbmb.2019.105439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pillerová M, Borbélyová V, Hodosy J, Riljak V, Renczés E, Frick KM, et al. On the role of sex steroids in biological functions by classical and non-classical pathways. An update. Front Neuroendocrinol. 2021;62:100926. https://doi.org/10.1016/j.yfrne.2021.100926.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bakhshi P, Ho JQ, Zanganeh S. Sex-specific outcomes in cancer therapy: the central role of hormones. Front Med Technol. 2024;6:1320690. https://doi.org/10.3389/fmedt.2024.1320690.

Article  PubMed  PubMed Central  Google Scholar 

Lopez-Lee C, Torres ERS, Carling G, Gan L. Mechanisms of sex differences in Alzheimer’s disease. Neuron. 2024;112:1208–21. https://doi.org/10.1016/j.neuron.2024.01.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terrin F, Tesoriere A, Plotegher N, Dalla Valle L. Sex and brain: the role of sex chromosomes and hormones in brain development and Parkinson’s disease. Cells. 2023;12:1486. https://doi.org/10.3390/cells12111486.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiese CB, Avetisyan R, Reue K. The impact of chromosomal sex on cardiometabolic health and disease. Trends Endocrinol Metab. 2023;34:652–65. https://doi.org/10.1016/j.tem.2023.07.003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poznyak AV, Sadykhov NK, Kartuesov AG, Borisov EE, Melnichenko AA, Grechko AV, et al. Hypertension as a risk factor for atherosclerosis: cardiovascular risk assessment. Front Cardiovasc Med. 2022;9:959285. https://doi.org/10.3389/fcvm.2022.959285.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goo Y-H. Cholesterol Metabolism in Atherosclerosis Development. In The Molecular Nutrition of Fats. Elsevier, 2019; pp. 299–306 ISBN 978–0–12–811297–7.

Pope JE, Cupp MJ, Tracy TS. Dehydroepiandrosterone (DHEA) (Prasterone). In Dietary Supplements: Toxicology and Clinical Pharmacology. Cupp MJ, Tracy TS, Eds. Humana Press: Totowa, NJ, 2003; pp. 123–147 ISBN 978–1–59259–303–3.

Greaves RF, Wudy SA, Badoer E, Zacharin M, Hirst JJ, Quinn T, et al. A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment. J Steroid Biochem Mol Biol. 2019;188:77–85. https://doi.org/10.1016/j.jsbmb.2018.12.007.

Article  CAS  PubMed  Google Scholar 

Klinge CM, Clark BJ, Prough RA. Dehydroepiandrosterone Research: Past, Current, and Future. In Vitamins and Hormones. Elsevier, 2018;108:1–28. ISBN 978–0–12–814361–2.

Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA. The regulation of steroid action by sulfation and desulfation. Endocr Rev. 2015;36:526–63. https://doi.org/10.1210/er.2015-1036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark BJ, Klinge CM. Structure-Function of DHEA Binding Proteins. In Vitamins and Hormones. Elsevier, 2023;123:587–617. ISBN 978–0–443–13455–5.

Wang S, Wang Y, Xu J, Chen Y. Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis? A systematic review and meta-analysis. Medicine. 2017;96:e6556. https://doi.org/10.1097/MD.0000000000006556.

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