Carapetis JR, Beaton A, Cunningham MW, Guilherme L, Karthikeyan G, Mayosi BM, et al. Acute rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers. 2016;14(2):15084.
Ambari AM, Radi B, Dwiputra B, Arityanti D, Rikl T, Inggriani MP, et al. Adherence to penicillin treatment is essential for effective secondary prevention of rheumatic heart disease: a systematic review and meta-analysis. Ann Med Surg. 2024;86(4):2116–23.
Pancholi V. Group A Streptococcus-mediated host cell signaling. Microbiol Spectr. 2019. https://doi.org/10.1128/microbiolspec.GPP3-0021-2018.
Article PubMed PubMed Central Google Scholar
Cunningham MW, Kirvan CA. Post-Streptococcal Autoimmune Sequelae, Rheumatic Fever and Beyond: A New Perspective. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. 2nd ed. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2022 [cited 2025 Oct 15]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK606314/.
Vyas HKN, Proctor EJ, McArthur J, Gorman J, Sanderson-Smith M. Current understanding of group A streptococcal biofilms. Curr Drug Targets. 2019;20(9):982–93.
Article CAS PubMed PubMed Central Google Scholar
Uchiyama S, Andreoni F, Schuepbach RA, Nizet V, Zinkernagel AS. DNase Sda1 allows invasive M1T1 group A Streptococcus to prevent TLR9-dependent recognition. PLoS Pathog. 2012;8(6):e1002736.
Article CAS PubMed PubMed Central Google Scholar
Guerra S, LaRock C. Group A Streptococcus interactions with the host across time and space. Curr Opin Microbiol. 2024;77:102420.
Article PubMed PubMed Central Google Scholar
Stevens DL, Bryant AE. Severe Group A Streptococcal Infections. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016 [cited 2025 Oct 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK333425/.
Karthikeyan G, Guilherme L. Acute rheumatic fever. Lancet. 2018;392(10142):161–74.
Laabei M, Ermert D. Catch me if you can: Streptococcus pyogenes complement evasion strategies. J Innate Immun. 2019;11(1):3–12.
Article CAS PubMed Google Scholar
Happonen L, Collin M. Immunomodulating enzymes from Streptococcus pyogenes-in pathogenesis, as biotechnological tools, and as biological drugs. Microorganisms. 2024;12(1):200.
Article CAS PubMed PubMed Central Google Scholar
Karthikeyan G, Watkins D, Bukhman G, Cunningham MW, Haller J, Masterson M, et al. Research priorities for the secondary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report. BMJ Glob Health. 2023;8(Suppl 9):e012468.
Article PubMed PubMed Central Google Scholar
Ralph AP, Webb R, Moreland NJ, McGregor R, Bosco A, Broadhurst D, et al. Searching for a technology-driven acute rheumatic fever test: the START study protocol. BMJ Open. 2021;11(9):e053720.
Article PubMed PubMed Central Google Scholar
Brouwer S, Rivera-Hernandez T, Curren BF, Harbison-Price N, De Oliveira DMP, Jespersen MG, et al. Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nat Rev Microbiol. 2023;21(7):431–47.
Article CAS PubMed PubMed Central Google Scholar
Anderson J, Imran S, Frost HR, Azzopardi KI, Jalali S, Novakovic B, et al. Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial. Nat Commun. 2022;13(1):769.
Article CAS PubMed PubMed Central Google Scholar
Soderholm AT, Barnett TC, Sweet MJ, Walker MJ. Group A streptococcal pharyngitis: immune responses involved in bacterial clearance and GAS-associated immunopathologies. J Leukoc Biol. 2018;103(2):193–213.
Article CAS PubMed Google Scholar
Fieber C, Kovarik P. Responses of innate immune cells to group A Streptococcus. Front Cell Infect Microbiol. 2014;4:140.
Article PubMed PubMed Central Google Scholar
Cunningham MW, Kirvan CA. Post-Streptococcal Autoimmune Sequelae, Rheumatic Fever and Beyond: A New Perspective. In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. 2nd ed. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2022 [cited 2025 Oct 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK606314/.
Guilherme L, Kalil J. Rheumatic heart disease: molecules involved in valve tissue inflammation leading to the autoimmune process and Anti-S. pyogenes vaccine. Front Immunol. 2013;4:352.
Article PubMed PubMed Central Google Scholar
Kirvan CA, Canini H, Swedo SE, Hill H, Veasy G, Jankelow D, et al. IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes. Front Cardiovasc Med. 2022;9:919700.
Article CAS PubMed Google Scholar
Guilherme L, Cury P, Demarchi LMF, Coelho V, Abel L, Lopez AP, et al. Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions. Am J Pathol. 2004;165(5):1583–91.
Article CAS PubMed PubMed Central Google Scholar
Chong DLW, Ingram RJ, Lowther DE, Muir R, Sriskandan S, Altmann DM. The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation. Immunology. 2012;136(3):325–33.
Article CAS PubMed PubMed Central Google Scholar
Chopra P, Gulwani H. Pathology and pathogenesis of rheumatic heart disease. Indian J Pathol Microbiol. 2007;50(4):685–97.
Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, Shevach EM, et al. Cardiac myosin-Th17 responses promote heart failure in human myocarditis. JCI Insight. 2016;1(9):e85851-85851.
Article PubMed PubMed Central Google Scholar
Wen Y, Zeng Z, Gui C, Li L, Li W. Changes in the expression of Th17 cell-associated cytokines in the development of rheumatic heart disease. Cardiovasc Pathol. 2015;24(6):382–7.
Article CAS PubMed Google Scholar
Bas HD, Baser K, Yavuz E, Bolayir HA, Yaman B, Unlu S, et al. A shift in the balance of regulatory T and T helper 17 cells in rheumatic heart disease. J Investig Med. 2014;62(1):78–83.
Article CAS PubMed Google Scholar
Auala T, Zavale BG, Mbakwem AÇ, Mocumbi AO. Acute rheumatic fever and rheumatic heart disease: highlighting the role of group A streptococcus in the global burden of cardiovascular disease. Pathogens. 2022;11(5):496.
Article CAS PubMed PubMed Central Google Scholar
Happonen L, Hauri S, Svensson Birkedal G, Karlsson C, de Neergaard T, Khakzad H, et al. A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies. Nat Commun. 2019;10(1):2727.
Article PubMed PubMed Central Google Scholar
Lorenz N, McGregor R, Whitcombe AL, Sharma P, Ramiah C, Middleton F, et al. An acute rheumatic fever immune signature comprising inflammatory markers, IgG3, and Streptococcus pyogenes-specific antibodies. iScience. 2024;27(8):110558.
Article CAS PubMed PubMed Central Google Scholar
Beltrame MH, Catarino SJ, Goeldner I, Boldt ABW, de Messias-Reason IJ. The lectin pathway of complement and rheumatic heart disease. Front Pediatr. 2014;2:148.
Catarino SJ, Andrade FA, Boldt ABW, Guilherme L, Messias-Reason IJ. Sickening or healing the heart? The association of ficolin-1 and rheumatic fever. Front Immunol. 2018;9:3009.
Article CAS PubMed PubMed Central Google Scholar
Syed S, Viazmina L, Mager R, Meri S, Haapasalo K. Streptococci and the complement system: interplay during infection, inflammation and autoimmunity. FEBS Lett. 2020;594(16):2570–85.
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