Flores K, Almeida C, Arriaza K, et al. mTOR in the development of hypoxic pulmonary hypertension associated with cardiometabolic risk factors [J]. Int J Mol Sci. 2024;25(20):11023.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sydykov A, Mamazhakypov A, Maripov A, et al. Pulmonary hypertension in acute and chronic high altitude maladaptation disorders [J]. Int J Environ Res Public Health. 2021;18(4):1692.

Article  PubMed  PubMed Central  Google Scholar 

Bonanni L, Ferri N. Bempedoic acid and the uric acid paradox: reflections on the recent meta-analysis [J]. Cardiovascular Drugs and Therapy, 2025.

Zhou Y, Chen M, Zheng J, et al. Insights into the relationship between serum uric acid and pulmonary hypertension (Review) [J]. Mol Med Rep. 2024;29(1):10.

Article  CAS  PubMed  Google Scholar 

Rowan SC, Keane MP, Gaine S, et al. Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways. Lancet Respir Med. 2016;4(3):225–36.

Article  PubMed  Google Scholar 

Bian JS, Chen J, Zhang J, et al. ErbB3 governs endothelial dysfunction in hypoxia-induced pulmonary hypertension. Circulation. 2024;150(19):1533–53.

Article  CAS  PubMed  Google Scholar 

Patel J. Doshi G. Crosstalk between ryanodine receptor 2 dysfunction and FK506-binding proteins in pulmonary hypertension [J]. Cardiovascular Drugs and Therapy; 2025.

Liu N, Xu H, Sun Q, et al. The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors. Oxid Med Cell Longev. 2021;2021:1470380.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y Z, Zhou C, Zhu L J, et al. Effects of macroporous resin extract of dendrobium officinale leaves in rats with hyperuricemia induced by fructose and potassium oxonate [J]. Comb Chem High Throughput Screen. 2022;25(8):1294–303.

Article  PubMed  Google Scholar 

Liu X, Chen TY, Gao TY, et al. Pro-inflammatory diets promote the formation of hyperuricemia. Front Endocrinol (Lausanne). 2024;15:1398917.

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, LI L, Zhang Y, et al. Recent advances in fructose intake and risk of hyperuricemia [J]. Biomed Pharmacother. 2020;131:110795.

Article  CAS  PubMed  Google Scholar 

Takata T, Isomoto H. Back to the physiology: renal tubular handling of uric acid and emerging strategies for managing hyperuricemia [J]. Intern Med; 2025.

Eckenstaler R, Benndorf RA. The role of ABCG2 in the pathogenesis of primary hyperuricemia and gout-an update. Int J Mol Sci. 2021;22(13):6678.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Zhang Y, Zeng C. Update on the epidemiology, genetics, and therapeutic options of hyperuricemia. Am J Transl Res. 2020;12(7):3167–81.

CAS  PubMed  PubMed Central  Google Scholar 

Jia L, Sun B, Nie A, et al. Rosmarinic acid attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions [J]. Phytomedicine. 2025;145:157084.

Article  CAS  PubMed  Google Scholar 

Ying Y, Zhang Y, Sun J, et al. Mechanism of intestinal flora affecting SLC2A9 transport function to promote the formation of hyperuricemia [J]. Heliyon. 2024;10(23):e40597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, Chen J, Liu Z, et al. The role of the intestinal microbiome in the pathogenesis and treatment of hyperuricemia: a review [J]. Food Sci Nutr. 2025;13(10):e70982.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee Y, Werlinger P, Suh JW, et al. Potential probiotic Lacticaseibacillus paracasei MJM60396 prevents hyperuricemia in a multiple way by absorbing purine, suppressing xanthine oxidase and regulating urate excretion in mice. Microorganisms. 2022;10(5):851.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou S, Wen X, Lessing D J, et al. Uric acid-degrading lacticaseibacillus paracasei CPU202306 ameliorates hyperuricemia by regulating uric acid metabolism and intestinal microecology in mice [J]. Probiotics Antimicrob Proteins; 2025.

Maloberti A, Tognola C, Garofani I, et al. Uric acid and metabolic syndrome: importance of hyperuricemia cut-off. Int J Cardiol. 2024;417:132527.

Article  PubMed  Google Scholar 

Gong M, Wen S, Nguyen T, et al. Converging relationships of obesity and hyperuricemia with special reference to metabolic disorders and plausible therapeutic implications [J]. Diabetes Metab Syndr Obes. 2020;13:943–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu W, Liu W, Xie D, et al. High level of uric acid promotes atherosclerosis by targeting NRF2-mediated autophagy dysfunction and ferroptosis. Oxid Med Cell Longev. 2022;2022:9304383.

Article  PubMed  Google Scholar 

Kimura Y, Tsukui D, Kono H. Uric acid in inflammation and the pathogenesis of atherosclerosis. Int J Mol Sci. 2021;22(22):12394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng Y, Liu F, Yang X, et al. The key role of uric acid in oxidative stress, inflammation, fibrosis, apoptosis, and immunity in the pathogenesis of atrial fibrillation. Front Cardiovasc Med. 2021;8:641136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong Z, Zhou J, Jiang S, et al. Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout. Hereditas. 2020;157(1):2.

Article  PubMed  PubMed Central  Google Scholar 

Hong Y, Yang M, Xu X, et al. Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia. Ren Fail. 2025;47(1):2532855.

Article  PubMed  PubMed Central  Google Scholar 

Chrysant SG. Association of hyperuricemia with cardiovascular diseases: current evidence. Hosp Pract. 2023;51(2):54–63.

Article  Google Scholar 

Nishizawa H, Maeda N, Shimomura I. Impact of hyperuricemia on chronic kidney disease and atherosclerotic cardiovascular disease. Hypertens Res. 2022;45(4):635–40.

Article  PubMed  Google Scholar 

Kuwabara M, Hisatome I, AE R, et al. Hyperuricemia, a new cardiovascular risk [J]. Nutr Metab Cardiovasc Dis. 2025;35(3):103796.

Article  PubMed  Google Scholar 

Wei X, Zhang M, Huang S, et al. Hyperuricemia: a key contributor to endothelial dysfunction in cardiovascular diseases [J]. Faseb j. 2023;37(7):e23012.

Article  CAS  PubMed  Google Scholar 

Hisatome I, Li P, Miake J, et al. Uric acid as a risk factor for chronic kidney disease and cardiovascular disease　- Japanese guideline on the management of asymptomatic hyperuricemia. Circ J. 2021;85(2):130–8.

Article  CAS  PubMed  Google Scholar 

Si K, Wei C, Xu L, et al. Hyperuricemia and the risk of heart failure: pathophysiology and therapeutic implications [J]. Front Endocrinol (Lausanne). 2021;12:770815.

Article  PubMed  PubMed Central  Google Scholar 

Braga TT, Foresto-Neto O, Camara NOS. The role of uric acid in inflammasome-mediated kidney injury. Curr Opin Nephrol Hypertens. 2020;29(4):423–31.

Article  CAS  PubMed  Google Scholar 

Li D, Yuan S, Deng Y, et al. The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications. Front Immunol. 2023;14:1282890.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian X, Chen S, Wang P, et al. Temporal relationship between hyperuricemia and hypertension and its impact on future risk of cardiovascular disease. Eur J Intern Med. 2023;111:82–9.

Article