Cao Y, Widyahening I, Sun X, Li S. Pathophysiology of type 2 diabetes: a focus on the metabolic differences among Southeast Asian, Chinese and Indian populations and how this impacts treatment. Diabetes Obes Metab. 2025. https://doi.org/10.1111/dom.70060.

Article  PubMed  PubMed Central  Google Scholar 

Berger M, Marx N, Marx-Schütt K. Cardiovascular risk reduction in patients with type 2 diabetes: what does the cardiologist need to know? Eur Cardiol. 2025;20:e09. https://doi.org/10.15420/ecr.2024.29.

Article  PubMed  PubMed Central  Google Scholar 

Prandi FR, Evangelista I, Sergi D, Palazzuoli A, Romeo F. Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants. Heart Fail Rev. 2023;28(3):597–606. https://doi.org/10.1007/s10741-021-10200-y.

Article  CAS  PubMed  Google Scholar 

Smati H, Qadeer YK, Rodriguez M, et al. Diabetic cardiomyopathy: what clinicians should know. Am J Med. 2025;138(3):387–95. https://doi.org/10.1016/j.amjmed.2024.10.026.

Article  CAS  PubMed  Google Scholar 

Ghosh N, Chacko L, Bhattacharya H, et al. Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11041126.

Article  PubMed  PubMed Central  Google Scholar 

Liu X, Ma Y, Wang X, et al. Cross-regulatory mechanisms linking ferroptosis, epigenetics, and circadian rhythm to mitochondrial quality control in diabetic cardiomyopathy. J Adv Res. 2025. https://doi.org/10.1016/j.jare.2025.09.046.

Article  PubMed  PubMed Central  Google Scholar 

Radzioch E, Dąbek B, Balcerczyk-Lis M, et al. Diabetic cardiomyopathy-from basics through diagnosis to treatment. Biomedicines. 2024. https://doi.org/10.3390/biomedicines12040765.

Article  PubMed  PubMed Central  Google Scholar 

Bai J, Liu C, Zhu P, Li Y. Novel insights into molecular mechanism of mitochondria in diabetic cardiomyopathy. Front Physiol. 2020;11:609157. https://doi.org/10.3389/fphys.2020.609157.

Article  PubMed  Google Scholar 

De Geest B, Mishra M. Role of oxidative stress in diabetic cardiomyopathy. Antioxidants. 2022. https://doi.org/10.3390/antiox11040784.

Article  PubMed  PubMed Central  Google Scholar 

Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021;169:317–42. https://doi.org/10.1016/j.freeradbiomed.2021.03.046.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Li Y, Wang W, et al. NOX1 promotes myocardial fibrosis and cardiac dysfunction via activating the TLR2/NF-κB pathway in diabetic cardiomyopathy. Front Pharmacol. 2022;13:928762. https://doi.org/10.3389/fphar.2022.928762.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Ma TY, Huang K, et al. Role of pyroptosis in diabetic cardiomyopathy: an updated review. Front Endocrinol (Lausanne). 2023;14:1322907. https://doi.org/10.3389/fendo.2023.1322907.

Article  PubMed  Google Scholar 

Wang B, Dai L, Liang H, et al. Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging. Cardiovasc Diabetol. 2025;24(1):331. https://doi.org/10.1186/s12933-025-02884-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Suo W, Zhang X, et al. Targeting mitochondrial quality control for diabetic cardiomyopathy: therapeutic potential of hypoglycemic drugs. Biomed Pharmacother. 2023;168:115669. https://doi.org/10.1016/j.biopha.2023.115669.

Article  CAS  PubMed  Google Scholar 

Bellemare M, Bourcier L, Iglesies-Grau J, et al. Mechanisms of diabetic cardiomyopathy: focus on inflammation. Diabetes Obes Metab. 2025;27(5):2326–38. https://doi.org/10.1111/dom.16242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Y, Zhao A, Li Y, et al. Roles of SIRT3 in cardiovascular and neurodegenerative diseases. Ageing Res Rev. 2025;104:102654. https://doi.org/10.1016/j.arr.2024.102654.

Article  CAS  PubMed  Google Scholar 

Li L, Zeng H, He X, Chen JX. Sirtuin 3 alleviates diabetic cardiomyopathy by regulating TIGAR and cardiomyocyte metabolism. J Am Heart Assoc. 2021;10(5):e018913. https://doi.org/10.1161/jaha.120.018913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Li D, Dong X, et al. LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy. Sci China Life Sci. 2022;65(6):1198–212. https://doi.org/10.1007/s11427-021-1982-8.

Article  CAS  PubMed  Google Scholar 

Song S, Ding Y, Dai GL, et al. Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation. Acta Pharmacol Sin. 2021;42(2):230–41. https://doi.org/10.1038/s41401-020-0490-7.

Article  CAS  PubMed  Google Scholar 

Chen Y, Zheng Y, Chen R, et al. Dihydromyricetin attenuates diabetic cardiomyopathy by inhibiting oxidative stress, inflammation and necroptosis via Sirtuin 3 activation. Antioxidants. 2023. https://doi.org/10.3390/antiox12010200.

Article  PubMed  PubMed Central  Google Scholar 

Wang LF, Li Q, Wen K, et al. CD38 deficiency alleviates diabetic cardiomyopathy by coordinately inhibiting pyroptosis and apoptosis. Int J Mol Sci. 2023. https://doi.org/10.3390/ijms242116008.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Wei X, Liu SL, et al. Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3. Phytother Res. 2021;35(8):4579–91. https://doi.org/10.1002/ptr.7175.

Article  CAS  PubMed  Google Scholar 

Guo Z, Tuo H, Tang N, et al. Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice. Int J Biol Sci. 2022;18(2):826–40. https://doi.org/10.7150/ijbs.65938.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Zhao Z, Fan Y, et al. Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019;1865(7):1905–14. https://doi.org/10.1016/j.bbadis.2018.04.009.

Article  CAS  PubMed  Google Scholar 

Liu YT, Qiu HL, Xia HX, et al. Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD(+)-SIRT3 pathway. Acta Pharmacol Sin. 2024;45(6):1175–88. https://doi.org/10.1038/s41401-024-01247-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zong X, Cheng K, Yin G, et al. SIRT3 is a downstream target of PPAR-α implicated in high glucose-induced cardiomyocyte injury in AC16 cells. Exp Ther Med. 2020;20(2):1261–8. https://doi.org/10.3892/etm.2020.8860.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei P, Zhang X, Yan C, et al. Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic strategies. Biogerontology. 2025;26(4):142. https://doi.org/10.1007/s10522-025-10273-4.

Article  PubMed  PubMed Central  Google Scholar