Pellegatti P, Raffaghello L, Bianchi G, Piccardi F, Pistoia V, Di Virgilio F (2008) Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase. PLoS One 3(7):e2599. https://doi.org/10.1371/journal.pone.0002599
Article CAS PubMed PubMed Central Google Scholar
Amores-Iniesta J, Barbera-Cremades M, Martinez CM, Pons JA, Revilla-Nuin B, Martinez-Alarcon L et al (2017) Extracellular ATP activates the NLRP3 inflammasome and is an early danger signal of skin allograft rejection. Cell Rep 21(12):3414–3426. https://doi.org/10.1016/j.celrep.2017.11.079
Article CAS PubMed PubMed Central Google Scholar
Wilhelm K, Ganesan J, Muller T, Durr C, Grimm M, Beilhack A et al (2010) Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med 16(12):1434–1438. https://doi.org/10.1038/nm.2242
Article CAS PubMed Google Scholar
Romagnani A, Rottoli E, Mazza EMC, Rezzonico-Jost T, De Ponte Conti B, Proietti M et al (2020) P2X7 receptor activity limits accumulation of T cells within tumors. Cancer Res 80(18):3906–3919. https://doi.org/10.1158/0008-5472.CAN-19-3807
Article CAS PubMed PubMed Central Google Scholar
Wilmes M, Pinto Espinoza C, Ludewig P, Stabernack J, Liesz A, Nicke A et al (2022) Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions. J Neuroinflammation 19(1):256. https://doi.org/10.1186/s12974-022-02601-z
Article CAS PubMed PubMed Central Google Scholar
Barbera-Cremades M, Baroja-Mazo A, Gomez AI, Machado F, Di Virgilio F, Pelegrin P (2012) P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release. FASEB J 26(7):2951–2962. https://doi.org/10.1096/fj.12-205765
Article CAS PubMed Google Scholar
Tarantini M, Vultaggio-Poma V, Falzoni S, Adinolfi E, Giuliani AL, Di Virgilio F (2025) In-vivo measurement of the extracellular ATP concentration by bio-luminescence: the pmeLUC probe. Methods Cell Biol 199:53–66. https://doi.org/10.1016/bs.mcb.2025.02.014
Article CAS PubMed Google Scholar
Di Virgilio F, Adinolfi E (2017) Extracellular purines, purinergic receptors and tumor growth. Oncogene 36(3):293–303. https://doi.org/10.1038/onc.2016.206
Article CAS PubMed Google Scholar
Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D et al (2009) Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem 284(15):10120–10128. https://doi.org/10.1074/jbc.M805805200
Article CAS PubMed PubMed Central Google Scholar
Adinolfi E, De Marchi E, Orioli E, Pegoraro A, Di Virgilio F (2019) Role of the P2X7 receptor in tumor-associated inflammation. Curr Opin Pharmacol 47:59–64. https://doi.org/10.1016/j.coph.2019.02.012
Article CAS PubMed Google Scholar
Burnstock G, Jacobson KA, Christofi FL (2017) Purinergic drug targets for gastrointestinal disorders. Curr Opin Pharmacol 37:131–141. https://doi.org/10.1016/j.coph.2017.10.011
Article CAS PubMed PubMed Central Google Scholar
Adinolfi E, De Marchi E, Grignolo M, Szymczak B, Pegoraro A (2023) The P2X7 receptor in oncogenesis and metastatic dissemination: new insights on vesicular release and adenosinergic crosstalk. Int J Mol Sci. https://doi.org/10.3390/ijms241813906
Article PubMed PubMed Central Google Scholar
Zanoni M, Pegoraro A, Adinolfi E, De Marchi E (2022) Emerging roles of purinergic signaling in anti-cancer therapy resistance. Front Cell Dev Biol 10:1006384. https://doi.org/10.3389/fcell.2022.1006384
Article PubMed PubMed Central Google Scholar
Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47(1):15–31. https://doi.org/10.1016/j.immuni.2017.06.020
Article CAS PubMed Google Scholar
von Kugelgen I (2019) Pharmacology of P2Y receptors. Brain Res Bull 151:12–24. https://doi.org/10.1016/j.brainresbull.2019.03.010
Dal Ben D, Buccioni M, Lambertucci C, Francucci B, Smirnov A, Spinaci A et al (2025) Radioligands targeting the purinergic P2X receptors. Cells. https://doi.org/10.3390/cells14130984
Article PubMed PubMed Central Google Scholar
Sattler C, Benndorf K (2022) Enlightening activation gating in P2X receptors. Purinergic Signal 18(2):177–191. https://doi.org/10.1007/s11302-022-09850-w
Article CAS PubMed PubMed Central Google Scholar
Illes P, Muller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ et al (2020) Update of P2X receptor properties and their pharmacology: IUPHAR review 30. Br J Pharmacol. https://doi.org/10.1111/bph.15299
Article PubMed PubMed Central Google Scholar
Alexander SPH, Striessnig J, Gibb AJ, Mathie AA, Veale EL, Kelly E et al (2025) The Concise Guide to PHARMACOLOGY 2025/26: Ion channels. Br J Pharmacol 182(Suppl 1):S152–S241. https://doi.org/10.1111/bph.70231
Article CAS PubMed Google Scholar
North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82(4):1013–1067. https://doi.org/10.1152/physrev.00015.2002
Article CAS PubMed Google Scholar
Di Virgilio F, Schmalzing G, Markwardt F (2018) The elusive P2X7 macropore. Trends Cell Biol 28(5):392–404. https://doi.org/10.1016/j.tcb.2018.01.005
Article CAS PubMed Google Scholar
Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S et al (2010) Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform. Mol Pharmacol 77(6):953–960. https://doi.org/10.1124/mol.110.063636
Article CAS PubMed Google Scholar
King BF (2023) Rehabilitation of the P2X5 receptor: a re-evaluation of structure and function. Purinergic Signal 19(2):421–439. https://doi.org/10.1007/s11302-022-09903-0
Article CAS PubMed Google Scholar
Ormond SJ, Barrera NP, Qureshi OS, Henderson RM, Edwardson JM, Murrell-Lagnado RD (2006) An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum. Mol Pharmacol 69(5):1692–1700. https://doi.org/10.1124/mol.105.020404
Article CAS PubMed Google Scholar
Antonio LS, Stewart AP, Varanda WA, Edwardson JM (2014) Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. FEBS Lett 588(12):2125–2128. https://doi.org/10.1016/j.febslet.2014.04.048
Article CAS PubMed Google Scholar
Diezmos EF, Bertrand PP, Liu L (2016) Purinergic signaling in gut inflammation: the role of connexins and pannexins. Front Neurosci 10:311. https://doi.org/10.3389/fnins.2016.00311
Article PubMed PubMed Central Google Scholar
Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448(7152):427–434. https://doi.org/10.1038/nature06005
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