Craske MG, Rauch SL, Ursano R, Prenoveau J, Pine DS, Zinbarg RE (2011) What is an anxiety disorder? Focus 9(3):369–388

Article  Google Scholar 

Liu J, Ning W, Zhang N, Zhu B, Mao Y (2024) Estimation of the global disease burden of depression and anxiety between 1990 and 2044: an analysis of the Global Burden of Disease Study 2019. Healthcare 12(17):1721. https://doi.org/10.3390/healthcare12171721

Article  PubMed  PubMed Central  Google Scholar 

Rotondo JC, Mazziotta C, Lanzillotti C et al (2022) The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications. Cancers (Basel) 14(5):1116. https://doi.org/10.3390/cancers14051116

Article  PubMed  PubMed Central  CAS  Google Scholar 

Smagin G, Iwata M, Ota K, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones K, Smagin G, Duman R (2015) Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptor. Biol Psychiatry 80(1):12–22. https://doi.org/10.1016/j.biopsych.2015.11.026

Article  PubMed  CAS  Google Scholar 

Zhong YT, Pi C, Zuo Y, Wei Y, Li W, Jiang YQ, Tao L, Zheng WW, Jiang J, Yang Y, Chu SF (2025) The P2X7 receptor in depression: Novel insights and therapeutic implications. Neurobiol Dis 27:107011

Article  Google Scholar 

Rhie SJ, Jung EY, Shim I (2020) The role of neuroinflammation on pathogenesis of affective disorders. J Exerc Rehabil 16(1):2–9. https://doi.org/10.12965/jer.2040016.008

Article  PubMed  PubMed Central  Google Scholar 

Felger JC (2018) Imaging the role of inflammation in mood and anxiety-related disorders. Curr Neuropharmacol 16(5):533–558

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu J, Liu TT, Mou L, Zhang Y, Chen X, Wang Q, Deng BL, Liu J. P2X7 receptor: a potential target for treating comorbid anxiety and depression. Purinergic Signal. 2024. https://doi.org/10.1007/s11302-024-10007-0

Kristof Z, Szabo D, Sperlagh B, Torok D, Gonda X (2025) From childhood woes to adult blues: unmasking the role of early traumas, P2X7 receptor, and neuroinflammation in anxiety and depression. Int J Mol Sci 26(10):4687. https://doi.org/10.3390/ijms26104687

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aricioglu F, Ozkartal CS, Bastaskin T, Tüzün E, Kandemir C, Sirvanci S, Kucukali CI, Utkan T (2019) Antidepressant-like effects induced by chronic blockade of the purinergic 2X7 receptor through inhibition of non-like receptor protein 1 inflammasome in chronic unpredictable mild stress model of depression in rats. Clin Psychopharmacol Neurosci 17(2):261

Article  PubMed  PubMed Central  CAS  Google Scholar 

Potula R, Gentile TA, Meissler JJ, Shekarabi A, Wiah S, Farkas DJ, Inan S, Eisenstein TK, Rawls SM (2023) Purinergic P2X7 receptor antagonist inhibits methamphetamine-induced reward, hyperlocomotion, and cortical IL-7A levels in mice: A role for P2X7/IL-17A crosstalk in methamphetamine behaviors? Brain Behav Immun 1(107):47–52

Article  Google Scholar 

Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47(1):15–31

Article  PubMed  Google Scholar 

De Salis SK, Li L, Chen Z, Lam KW, Skarratt KK, Balle T, Fuller SJ (2022) Alternatively spliced isoforms of the P2X7 receptor: structure, function and disease associations. Int J Mol Sci 23(15):8174

Article  PubMed  PubMed Central  Google Scholar 

Zou YT, Li JY, Chai JY, Hu YS, Zhang WJ, Zhang Q (2024) The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression. Biochem Biophys Res Commun 707(7):149513

Article  PubMed  CAS  Google Scholar 

Lara R, Adinolfi E, Harwood CA et al (2020) P2X7 in cancer: from molecular mechanisms to therapeutics. Front Pharmacol 11:793. https://doi.org/10.3389/fphar.2020.00793

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shokoples BG, Paradis P, Schiffrin EL (2021) P2X7 receptors: an untapped target for the management of cardiovascular disease. Arterioscler Thromb Vasc Biol 41(1):186–199. https://doi.org/10.1161/ATVBAHA.120.315116

Article  PubMed  CAS  Google Scholar 

Savio LEB, de Andra Mello P, da Silva CG, Coutinho-Silva R (2018) The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol 9:52. https://doi.org/10.3389/fphar.2018.00052

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hill LM, Gavala ML, Lenertz LY, Bertics PJ (2010) Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes. J Immunol 185(5):3028–3034. https://doi.org/10.4049/jimmunol.1001298

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akcay E, Karatas H (2024) P2X7 receptors from the perspective of NLRP3 inflammasome pathway in depression: potential role of cannabidiol. Brain, Behavior, & Immunity - Health 41:100853. https://doi.org/10.1016/j.bbih.2024.100853

Article  CAS  Google Scholar 

Ahire C, Kaur G (2025) Targeting the P2X7 receptor signaling pathway: unlocking therapeutic strategies for autism spectrum disorder. Brain, Behavior, & Immunity - Health 47:101037. https://doi.org/10.1016/j.bbih.2025.101037

Article  CAS  Google Scholar 

Fan X, Ma W, Zhang Y, Zhang L (2020) P2X7 receptor (P2X7R) of microglia mediates neuroinflammation by regulating (NOD)-like receptor protein 3 (NLRP3) inflammasome-dependent inflammation after spinal cord injury. Med Sci Monit 26:e925491. https://doi.org/10.12659/MSM.925491

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ribeiro DE, Roncalho AL, Glaser T, Ulrich H, Wegener G, Joca S (2019) P2X7 receptor signaling in stress and depression. Int J Mol Sci 20(6):2778. https://doi.org/10.3390/ijms20112778

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhao YF, Tang Y, Illes P (2021) Astrocytic and oligodendrocytic P2X7 receptors determine neuronal functions in the CNS. Front Mol Neurosci 14(9):641570

Article  PubMed  PubMed Central  CAS  Google Scholar 

Miras-Portugal MT, Sebastián-Serrano Á, de Diego GL, Díaz-Hernández M (2017) Neuronal P2X7 receptor: involvement in neuronal physiology and pathology. J Neurosci 37(30):7063–7072

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zelentsova AS, Deykin AV, Soldatov VO, Ulezko AA, Borisova AY, Belyaeva VS, Skorkina MY, (2022) Angelova PR. P2X7 receptor and purinergic signaling: orchestrating mitochondrial dysfunction in neurodegenerative diseases. Eneuro. 9(6)

Cuesta JM, Singer M (2012) The stress response and critical illness: a review. Crit Care Med 40(12):3283–3289

Article  PubMed  Google Scholar 

Fan X, Wang J, Ma Y, Chai D, Han S, Xiao C, Huang Y, Wang X, Wang J, Wang S, Xiao L (2024) Activation of P2X7 Receptor Mediates the Abnormal Ovulation Induced by Chronic Restraint Stress and Chronic Cold Stress. Biology 13(8):620

Article  PubMed  PubMed Central  CAS  Google Scholar 

Swayne LA, Boyce AK (2017) Regulation of pannexin 1 surface expression by extracellular ATP: potential implications for nervous system function in health and disease. Front Cell Neurosci 8(11):230

Article  Google Scholar 

Illes P (2020) P2X7 receptors amplify CNS damage in neurodegenerative diseases. Int J Mol Sci 21(17):5996. https://doi.org/10.3390/ijms21175996

Article  PubMed  PubMed Central  CAS  Google Scholar 

Golia MT, Gabrielli M, Verderio C (2023) P2X7 receptor and extracellular vesicle release. Int J Mol Sci 24(12):9805

Article  PubMed  PubMed Central  CAS