Nie L, Yao D, Chen S, Wang J, Pan C, Wu D, Liu N, Tang Z (2023) Directional induction of neuralstem cells, a new therapy for neurodegenerative diseases and ischemic stroke. Cell Death Discov 9(1):215
Article PubMed PubMed Central CAS Google Scholar
Liu C, Wang J, Wang Z, Fan X, Pan J, Guo X, Zhou S (2025Jul) Discoidal nanoparticles exploit thrombus-induced shear gradients to enhance site-specific thrombolysis in stroke. Acta Biomater 1(201):471–484
Fredholm BB (2007) Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ 14:1315–1323
Article PubMed CAS Google Scholar
Vecchio Elizabeth, White Paul, May Lauren. The adenosine A2B G protein-coupled receptor: recent advances and therapeutic implications[J]. Pharmacology & Therapeutics, 2019, 198. 20–33.
Melani Alessia, Pugliese Anna, Pedata Felicita. Adenosine receptors in cerebral ischemia[J]. International Review of Neurobiology, 2014, 119. 309–48.
Liu Y, Chen J, Li X et al (2019) Research progress on adenosine in central nervous system diseases. CNS Neurosci Ther 25(9):899–910
Article PubMed PubMed Central Google Scholar
Peeters MC, Li Q, van Westen GJ, Ijzerman AP (2012) Three “hotspots” important for adenosine A(2B) receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop. Purinergic Signal 8(1):23–38
Article PubMed CAS Google Scholar
Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR. Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids. Genomics. 1995 Jan 20;25(2):605–7.
Feoktistov I, Biaggioni I (1997) Adenosine A2B receptors. Pharmacol Rev 49(4):381–402
Article PubMed CAS Google Scholar
Erices JI, Niechi I, Uribe-Ojeda A, Toro MLÁ, García-Romero N, Carrión-Navarro J, Monago-Sánchez Á, Ayuso-Sacido Á, Martin RS, Quezada-Monrás C (2022Aug) The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells. Front Oncol 18(12):969993
Fredholm BB,Chen JF,Cunha RA,et al.Adenosine and brain function[J].Int Rev Neurobiol,2005,63:191–270
Wang Junyan, Wang Dan, Zheng Xiaomin, et al. A2B adenosine receptor inhibition ameliorates hypoxic-ischemic injury in neonatal mice via PKC/Erk/Creb/HIF-1α signaling pathway[J]. Brain Research, 2022, 1782. 147837.
Roberts V, Lu B, Dwyer K et al (2014) Adenosine receptor expression in the development of renal fibrosis following ischemic injury. Transplant Proc 46(10):3257–61
Article PubMed CAS Google Scholar
Zhuang Hao, Lei Wen, Wu Qiang, et al. Overexpressed CD73 attenuates GSDMD-mediated astrocyte pyroptosis induced by cerebral ischemia-reperfusion injury through the A2B/NF-κB pathway[J]. Experimental Neurology, 2025, 386. 115152.
Pinar U, Ozlenen O, Matteo A et al (2020) Does ischemic preconditioning increase flap survival by ADORA2B receptor activation[J]. Clin Hemorheol Microcirc 75(2):151–162
Li Qiang, Han Xiaoning, Lan Xi, et al. Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia[J]. Neurobiology of Disease, 2017, 108. 173–182.
Dettori Ilaria, Gaviano Lisa, Ugolini Filippo, et al. Protective effect of adenosine A2B receptor agonist, BAY60–6583, against transient focal brain ischemia in rat[J]. Frontiers in Pharmacology, 2020, 11. 588757.
Headrick JP, Lasley RD. Adenosine receptors and reperfusion injury of the heart. Handb Exp Pharmacol. 2009;(193):189–214.
Ishioh M, Nozu T, Miyagishi S, Igarashi S, Funayama T, Ueno N, Okumura T (2024) Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats. Biochem Pharmacol 224:116201
Article PubMed CAS Google Scholar
Kawamura M Jr, Ruskin DN, Masino SA (2019Aug 1) Adenosine A receptor-mediated protection of mouse hippocampal synaptic transmission against oxygen and/or glucose deprivation: a comparative study. J Neurophysiol 122(2):721–728
Article PubMed PubMed Central Google Scholar
Pedata F, Pugliese AM, Coppi E, Dettori I, Maraula G, Cellai L, Melani A (2014) Adenosine A2A receptors modulate acute injury and neuroinflammation in brain ischemia. Mediators Inflamm 2014:805198
Article PubMed PubMed Central Google Scholar
Dettori I, Gaviano L, Ugolini F, Lana D, Bulli I, Magni G, Rossi F, Giovannini MG, Pedata F (2021Feb) Protective effect of adenosine A2B receptor agonist, BAY60-6583, against transient focal brain ischemia in rat. Front Pharmacol 11(11):588757
Article PubMed PubMed Central Google Scholar
Du X, Ou X, Song T, Zhang W, Cong F, Zhang S, Xiong Y (2015) Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells. Exp Biol Med (Maywood) 240(11):1472–1479
Article PubMed PubMed Central CAS Google Scholar
Coppi E, Dettori I, Cherchi F, Bulli I, Venturini M, Lana D, Giovannini MG, Pedata F, Pugliese AM (2020Dec 18) A2B adenosine receptors: when outsiders may become an attractive target to treat brain ischemia or demyelination. Int J Mol Sci 21(24):9697
Article PubMed PubMed Central CAS Google Scholar
Fusco I, Ugolini F, Lana D et al (2018) The selective antagonism of adenosine A2B receptors reduces the synaptic failure and neuronal death induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro. Front Pharmacol 9:399
Article PubMed PubMed Central Google Scholar
Liu YJ, Chen J, Li X, Zhou X, Hu YM, Chu SF, Peng Y, Chen NH (2019) Research progress on adenosine in central nervous system diseases. CNS Neurosci Ther 25(9):899–910
Article PubMed PubMed Central Google Scholar
Liu Y, Chu S, Hu Y et al (2020) Exogenous adenosine antagonizes excitatory amino acid toxicity in primary astrocytes. Cell Mol Neurobiol 41(4):687–704
Article PubMed PubMed Central Google Scholar
Wei W, Du C, Lv J, Zhao G, Li Z, Wu Z, Haskó G, Xie X (2013Jan 1) Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation. J Immunol 190(1):138–146
Article PubMed CAS Google Scholar
Ronaldson PT, Davis TP (2020) Regulation of blood-brain barrier integrity by microglia in health and disease: a therapeutic opportunity. J Cereb Blood Flow Metab 40(1_suppl):S6–S24
Article PubMed PubMed Central CAS Google Scholar
Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA, Rial D (2015) Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus. Eur J Neurosci 41(7):878–888
Fusco I, Cherchi F, Catarzi D, Colotta V, Varano F, Pedata F, Pugliese AM, Coppi E (2019) Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus. Brain Res Bull 151:174–180
Article PubMed CAS Google Scholar
Dettori Ilaria, Bulli Irene, Venturini Martina, et al. MRS3997, a dual adenosine [32]Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi A, Konstantinou C, Esteras N, Gutierrez Del Arroyo A, Ackland GL, Teschemacher AG, Dale N, Eckle T, Andrikopoulos P, Rusakov DA, Kasparov S, Gourine AV. Adenosine signalling to astrocytes coordinates brain metabolism and function. Nature. 2024 Aug;632(8023):139–146.
Kumar M, Kaur K, Singh T (2022) Neuroprotective effects of carbonic anhydrase inhibition and cyclic adenosine monophosphate activation in mouse model of transient global cerebral ischemia and reperfusion. Neuromol Med 25(2):217–229
Kalra Palak, Khan Heena, Singh Thakur, et al. Mechanistic insights on impact of adenosine monophosphate-activated protein kinase (AMPK) mediated signalling pathways on cerebral ischemic injury[J]. Neuroscience Research, 2022, 190. 17–28.
Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K (2006) The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest 116(7):1913–1923
Article PubMed PubMed Central CAS Google Scholar
Dettori Ilaria, Bulli Irene, Venturini Martina, et al. MRS3997, a dual adenosine A2A/A2B receptor agonist, reduces brain ischemic damage and alleviates neuroinflammation in rats[J]. Neuropharmacology, 2024, 262. 110214.
Almut G, Jae-Hwan K, Jessica B et al (2017Jul 1) Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release[J]. J Immunol 199(1):363
Chu S, Xiong W, Zhang D et al (2012) Regulation of adenosine levels during cerebral ischemia. Acta Pharmacol Sin 34(1):60–66
Article PubMed PubMed Central Google Scholar
Pedata Felicita, Dettori Ilaria, Coppi Elisabetta, et al. Purinergic signalling in brain ischemia[J]. Neuropharmacology, 2015, 104. 105–30.
Rivera-Oliver M, Díaz-Ríos M (2014) Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review. Life Sci 101(1–2):1–9
Article PubMed PubMed Central Google Scholar
Colotta V, Lenzi O, Catarzi D, Varano F, Squarcialupi L, Costagli C, Galli A, Ghelardini C, Pugliese AM, Maraula G, Coppi E, Pellegrini-Giampietro DE, Pedata F, Sabbadin D, Moro S (2012) 3-hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. Eur J Med Chem 54:470–482
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