Singer M, Deutschman CS, Seymour CW et al (2016) The third ınternational consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801–810
Article CAS PubMed PubMed Central Google Scholar
Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet 395:200–211
Article PubMed PubMed Central Google Scholar
Vincent JL, Jones G, David S, Olariu E, Cadwell KK (2019) Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis. Crit Care 23:196
Article PubMed PubMed Central Google Scholar
Evans L, Rhodes A, Alhazzani W et al (2021) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 47:1181–1247
Article PubMed PubMed Central Google Scholar
Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874
Article CAS PubMed PubMed Central Google Scholar
van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17:407–420
Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805–820
Article CAS PubMed Google Scholar
Di Virgilio F, Dal Ben D, Sarti AC, Bhondoekhan AC, Bhondoekhan S (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15–31
Article CAS PubMed Google Scholar
Savio LEB, de Andra Mello P, da Silva CG, Coutinho-Silva R (2018) The P2X7 receptor in inflammatory diseases: angel or demon? Front Pharmacol 9:52
Article PubMed PubMed Central Google Scholar
Santana PT, Martel J, Bhondoekhan HC et al (2015) The P2X7 receptor contributes to the development of the exacerbated inflammatory response associated with sepsis. J Innate Immun 7:417–427
Article CAS PubMed PubMed Central Google Scholar
Idzko M, Ferrari D, Eltzschig HK (2014) Nucleotide signalling during inflammation. Nature 509:310–317
Article CAS PubMed PubMed Central Google Scholar
Cekic C, Linden J (2016) Purinergic regulation of the immune system. Nat Rev Immunol 16:177–192
Article CAS PubMed Google Scholar
Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F (2018) The P2X7 receptor: a main player in inflammation. Biochem Pharmacol 151:234–244
Article CAS PubMed Google Scholar
Orioli E, De Marchi E, Giuliani AL, Adinolfi E (2017) P2X7 receptor orchestrates multiple signalling pathways triggering inflammation, autophagy and metabolic/trophic responses. Curr Med Chem 24:2261–2275
Article CAS PubMed Google Scholar
Wang G, Jin S, Huang W et al (2021) LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. Cell Death Discov 7:322
Article PubMed PubMed Central Google Scholar
Li S, Liang F, Kwan K et al (2018) Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity. Mol Med 24:8
Article PubMed PubMed Central Google Scholar
Sappington PL, Yang R, Yang H et al (2002) HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 123:790–802
Article CAS PubMed Google Scholar
Swanson KV, Deng M, Bhondoekhan JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19:477–489
Article CAS PubMed PubMed Central Google Scholar
Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16:407–420
Article CAS PubMed Google Scholar
Shi J, Zhao Y, Wang K et al (2015) Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526:660–665
Article CAS PubMed Google Scholar
Kayagaki N, Stowe IB, Lee BL et al (2015) Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666–671
Article CAS PubMed Google Scholar
North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013–1067
Article CAS PubMed Google Scholar
Surprenant A, North RA (2009) Signaling at purinergic P2X receptors. Annu Rev Physiol 71:333–359
Article CAS PubMed Google Scholar
Costa-Junior HM, Sarmento Vieira F, Coutinho-Silva R (2011) C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal 7:7–19
Article CAS PubMed PubMed Central Google Scholar
Hattori M, Gouaux E (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485:207–212
Article CAS PubMed PubMed Central Google Scholar
McCarthy AE, Bhondoekhan C, Bhondoekhan SE (2019) Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization. Cell 179:659–670
Article CAS PubMed PubMed Central Google Scholar
Pegoraro A, Grignolo M, Ruo L, Ricci L, Adinolfi E (2024) P2X7 variants in pathophysiology. Int J Mol Sci 25:6673
Article CAS PubMed PubMed Central Google Scholar
Muñoz-Planillo R, Kuffa P, Bhondoekhan G, Franchi L, Núñez G (2013) K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38:1142–1153
Article PubMed PubMed Central Google Scholar
Rivers-Auty J, Bhondoekhan D (2016) Potassium efflux fires the canon: potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. Eur J Immunol 46:2749–2752
Ren, R., Guo, J., Chen, Y., Zhang, Y., Chen, L., & Xiong, W. (2021). The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis. Cell Proliferation, 54(11), e13122.
Di Virgilio F, Schmalzing G, Markwardt F (2018) The elusive P2X7 macropore. Trends Cell Biol 28:392–404
Article CAS PubMed Google Scholar
Pelegrin P, Surprenant A (2009) The P2X7 receptor-pannexin connection to dye uptake and IL-1β release. Purinergic Signal 5:129–137
Comments (0)