National Comprehensive Cancer Network (2025) NCCN clinical practice guidelines in oncology (NCCN Guidelines®) Cancer-Associated Venous Thromboembolic Disease V.3.2025. © National Comprehensive Cancer Network, Inc. 2025. All rights reserved. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1423

Mulder FI, Horváth-Puhó E, van Es N et al (2021) Venous thromboembolism in cancer patients: a population-based cohort study. Blood 137:1959–1969

Article  CAS  PubMed  Google Scholar 

Chinese Society of Clinical Oncology and Thrombosis expert Committee (2019) Chin Oncol Clin 46(13):653–660 (in Chinese). https://doi.org/10.3969/j.issn.1000-8179.2019.13.765. Guidelines for the prevention and treatment of tumor-associated venous thromboembolism (2019 edition) [J]

Weitz JI, Haas S, Ageno W, Goldhaber SZ, Turpie AGG, Goto S et al (2020) Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE. J Thromb Thrombolysis 50(2):267–277. https://doi.org/10.1007/s11239-020-02180-x

Article  CAS  PubMed  Google Scholar 

Spirk D, Sebastian T, Beer JH, Mazzolai L, Aujesky D, Hayoz D, Engelberger RP, Korte W, Kucher N, Barco S (2022) Role of age, sex, and specific provoking factors on the distal versus proximal presentation of first symptomatic deep vein thrombosis: analysis of the Swiss venous thromboembolism registry (SWIVTER). Intern Emerg Med 17(3):799–803. https://doi.org/10.1007/s11739-021-02878-7

Article  PubMed  Google Scholar 

Mahajan A, Brunson A, Eldredge J, White RH, Keegan THM, Wun T (2022) Incidence and outcomes associated with 6,841 isolated distal deep vein thromboses in patients with 13 common cancers. Thromb Haemost 122(8):1407–1414. https://doi.org/10.1055/a-1742-0177

Article  PubMed  Google Scholar 

Galanaud JP, Trujillo-Santos J, Bikdeli B, Bertoletti L, Di Micco P, Poénou G, Falgá C, Zdraveska M, Lima J, Rivera-Civico F, Muixi JF, Monreal M (2024) Clinical presentation and outcomes of patients with cancer-associated isolated distal deep vein thrombosis. J Clin Oncol 42(5):529–537. https://doi.org/10.1200/JCO.23.00429

Article  CAS  PubMed  Google Scholar 

Bikdeli B, Caraballo C, Trujillo-Santos J, Galanaud JP, di Micco P, Rosa V et al (2022) Clinical presentation and short- and long-term outcomes in patients with isolated distal deep vein thrombosis vs proximal deep vein thrombosis in the RIETE registry. JAMA Cardiol 7(8):857–865. https://doi.org/10.1001/jamacardio.2022.1988

Article  PubMed  PubMed Central  Google Scholar 

Blom JW, Doggen CJ, Osanto S et al (2005) Malignancies, prothrombotic mutations, and the risk of venous thrombosis[J]. JAMA 293(6):715–722. https://doi.org/10.1001/jama.293.6.715

Article  CAS  PubMed  Google Scholar 

Englisch C, Moik F, Nopp S et al (2022) ABO blood group type and risk of venous thromboembolism in patients with cancer[J]. Blood Adv 6(24):6274–6281. https://doi.org/10.1182/bloodadvances.2021006283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merkow RP, Bilimoria KY, McCarter MD et al (2011) Post–discharge venous thromboembolism after cancer surgery: extending the case for extended prophylaxis[J]. Ann Surg 254(1):131–137. 10.1097/ SLA.0b013e31821b98da

Article  PubMed  Google Scholar 

Pasha AK, Kuczmik W, Wysokinski WE, Casanegra AI, Houghton D, Vlazny DT, Mertzig A, Hirao-Try Y, White L, Hodge D, McBane R Ii (2021) Calf vein thrombosis outcomes comparing patients with and without cancer. J Thromb Thrombolysis 51(4):1059–1066. https://doi.org/10.1007/s11239-021-02390-x

Article  CAS  PubMed  Google Scholar 

Blom JW, Doggen CJ, Osanto S et al (2005) Malignancies,prothrombotic mutations, and the risk of venous thrombosis[J]. JAMA 293(6):715–722. https://doi.org/10.1001/jama.293.6.715

Article  CAS  PubMed  Google Scholar 

Cronin-Fenton DP, Søndergaard F, Pedersen LA et al (2010) Hospitalisation for venous thromboembolism in cancer patients and the general population: a population-based cohort study in Denmark, 1997–2006. Br J Cancer 103(7):947–953. https://doi.org/10.1038/sj.bjc.6605883

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heit JA, Silverstein MD, Mohr DN et al (2000) Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 160(6):809–815. https://doi.org/10.1001/archinte.160.6.809

Article  CAS  PubMed  Google Scholar 

Hammond J, Kozma C, Hart JC et al (2011) Rates of venous thromboembolism among patients with major surgery for cancer. Ann Surg Oncol 18:3240–3247

Article  PubMed  Google Scholar 

De Maeseneer MG, Bochanen N, van Rooijen G, Neglén P (2016) Analysis of 1,338 patients with acute lower limb deep venous thrombosis (DVT) supports the inadequacy of the term “proximal DVT.” Eur J Vasc Endovasc Surg 51(3):415–20. https://doi.org/10.1016/j.ejvs.2015.11.001

Article  CAS  PubMed  Google Scholar 

Falanga A, Ay C, Di Nisio M, Gerotziafas G, Jara-Palomares L, Langer F et al (2023) ESMO guidelines Committee. Electronic address: clinicalguidelines@esmo.org. Venous thromboembolism in cancer patients: ESMO clinical practice guideline. Ann Oncol 34(5):452–467. https://doi.org/10.1016/j.annonc.2022.12.014

Article  CAS  PubMed  Google Scholar 

Sartori M, Migliaccio L, Favaretto E et al (2014) Two years outcome of isolated distal deep vein thrombosis. Thromb Res 134(1):36–40

Article  CAS  PubMed  Google Scholar 

Dentali F, Barco S, Pegoraro S et al (2018) Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer. J Thromb Thrombolysis 46(3):404–408

Article  CAS  PubMed  Google Scholar 

Poudel SK, Park DY, Jia X, Wilks M, Pinkava V, O’Brien M, Tripp B, Song JM, McCrae KR, Khorana AA, Angelini DE (2020) Clinical outcomes of isolated distal deep vein thrombosis versus proximal venous thromboembolism in cancer patients: the Cleveland clinic experience. J Thromb Haemost 18(3):651–659. https://doi.org/10.1111/jth.14700

Article  PubMed  Google Scholar 

Galanaud JP, Sevestre MA, Pernod G, Genty C, Richelet S, Kahn SR, Boulon C, Terrisse H, Quéré I, Bosson JL (2017) Long-term outcomes of cancer-related isolated distal deep vein thrombosis: the OPTIMEV study. J Thromb Haemost 15(5):907–916

Article  PubMed  Google Scholar 

Brown C, Brandt W, Wang TF, Delluc A, Carrier M (2023) Incidence of recurrent venous thromboembolism and bleeding complications in patients with cancer and isolated distal deep vein thrombosis. Thromb Res 228:81–84. https://doi.org/10.1016/j.thromres.2023.05.027

Article  CAS  PubMed  Google Scholar 

Kearon C, Kahn SR (2020) Long-term treatment of venous thromboembolism. Blood 135(5):30–325. https://doi.org/10.1182/blood.2019002364

Article  Google Scholar 

Stevens SM, Woller SC, Kreuziger LB, Bounameaux H, Doerschug K, Geersing GJ, Huisman MV, Kearon C, King CS, Knighton AJ, Lake E, Murin S, Vintch JRE, Wells PS, Moores LK (2021) Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report. Chest 160(6):e545–e608. https://doi.org/10.1016/j.chest.2021.07.055

Article  CAS  PubMed  Google Scholar 

Agnelli G, Becattini C, Meyer G, Muñoz A, Huisman MV, Connors JM, Cohen A, Bauersachs R, Brenner B, Torbicki A, Sueiro MR, Lambert C, Gussoni G, Campanini M, Fontanella A, Vescovo G, Verso M (2020) Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 382(23):1599–1607. https://doi.org/10.1056/NEJMoa1915103

Article  CAS  PubMed  Google Scholar 

McBane RD 2nd, Wysokinski WE, Le-Rademacher JG, Zemla T, Ashrani A, Tafur A, Perepu U, Anderson D, Gundabolu K, Kuzma C, Perez Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Houghton DE, Vishnu P, Loprinzi CL (2020) Apixaban and dalteparin in active malignancy-associated venous thromboembolism: the ADAM VTE trial. J Thromb Haemost 18(2):411–421. https://doi.org/10.1111/jth.14662

Article  CAS  PubMed  Google Scholar 

Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, Grosso MA, Kakkar AK, Kovacs MJ, Mercuri MF, Meyer G, Segers A, Shi M, Wang TF, Yeo E, Zhang G, Zwicker JI, Weitz JI, Büller HR, Hokusai VTE Cancer Investigators (2018) Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 378(7):615–624. https://doi.org/10.1056/NEJMoa1711948

Article  CAS  PubMed  Google Scholar 

Yamashita Y, Morimoto T, Muraoka N, Ono K, Kimura T, ONCO DVT Study Investigators (2025) Extended anticoagulation therapy on clinical outcomes in patients with gastrointestinal cancer and isolated distal deep vein thrombosis: insights from the ONCO DVT Study. Eur J Intern Med 141:106400. https://doi.org/10.1016/j.ejim.2025.06.029

Article  CAS