Beyond weight loss: Integrating GLP-1 RA therapies into psychological and behavioral care for obesity and binge eating disorder

Bray GA, Kim KK, Wilding JPH. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes Rev. 2017;18(7):715–23. https://doi.org/10.1111/obr.12551.

Article  CAS  PubMed  Google Scholar 

Rosenbaum DL, White KS. Understanding the complexity of biopsychosocial factors in the public health epidemic of overweight and obesity. Health Psychol Open. 2016;3(1):2055102916634364. https://doi.org/10.1177/2055102916634364.

Article  PubMed  PubMed Central  Google Scholar 

Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity management in adults: a review. JAMA. 2023;330(20):2000–15. https://doi.org/10.1001/jama.2023.19897.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leutner M, Dervic E, Bellach L, Klimek P, Thurner S, Kautzky A. Obesity as pleiotropic risk state for metabolic and mental health throughout life. Transl Psychiatry. 2023;13(1):175. https://doi.org/10.1038/s41398-023-02447-w.

Article  PubMed  PubMed Central  Google Scholar 

Giel KE, Bulik CM, Fernandez-Aranda F, Hay P, Keski-Rahkonen A, Schag K, et al. Binge eating disorder. Nat Rev Dis Primers. 2022;8(1):16. https://doi.org/10.1038/s41572-022-00344-y.

Article  PubMed  PubMed Central  Google Scholar 

Heriseanu AI, Hay P, Corbit L, Touyz S. Grazing in adults with obesity and eating disorders: a systematic review of associated clinical features and meta-analysis of prevalence. Clin Psychol Rev. 2017;58:16–32. https://doi.org/10.1016/j.cpr.2017.09.004.

Article  PubMed  Google Scholar 

Kaur J, Dang AB, Gan J, An Z, Krug I. Night eating syndrome in patients with obesity and binge eating disorder: a systematic review. Front Psychol. 2021;12:766827. https://doi.org/10.3389/fpsyg.2021.766827.

Article  PubMed  Google Scholar 

van Strien T. Causes of emotional eating and matched treatment of obesity. Curr Diab Rep. 2018;18(6):35. https://doi.org/10.1007/s11892-018-1000-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chew HSJ, Lau ST, Lau Y. Weight-loss interventions for improving emotional eating among adults with high body mass index: a systematic review with meta-analysis and meta-regression. Eur Eat Disord Rev. 2022;30(4):304–27. https://doi.org/10.1002/erv.2906.

Article  PubMed  PubMed Central  Google Scholar 

Schag K, Schönleber J, Teufel M, Zipfel S, Giel KE. Food-related impulsivity in obesity and binge eating disorder--a systematic review. Obes Rev. 2013;14(6):477–95. https://doi.org/10.1111/obr.12017.

Article  CAS  PubMed  Google Scholar 

Gearhardt AN, White MA, Potenza MN. Binge eating disorder and food addiction. Curr Drug Abuse Rev. 2011;4(3):201–7. https://doi.org/10.2174/1874473711104030201.

Article  PubMed  PubMed Central  Google Scholar 

Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry. 2013;73(9):877–86. https://doi.org/10.1016/j.biopsych.2013.01.014.

Article  PubMed  PubMed Central  Google Scholar 

Yau YH, Potenza MN. Stress and eating behaviors. Minerva Endocrinol. 2013;38(3):255–67.

CAS  PubMed  PubMed Central  Google Scholar 

Sainsbury K, Evans EH, Pedersen S, Marques MM, Teixeira PJ, Lähteenmäki L, et al. Attribution of weight regain to emotional reasons amongst European adults with overweight and obesity who regained weight following a weight loss attempt. Eat Weight Disord. 2019;24(2):351–61. https://doi.org/10.1007/s40519-018-0487-0.

Article  PubMed  Google Scholar 

Schrempft S, Jiménez-Sánchez C, Baysson H, Zaballa ME, Lamour J, Stringhini S, et al. Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction. Int J Obes (Lond). 2025;49(7):1317–26. https://doi.org/10.1038/s41366-025-01772-y.

Article  PubMed  PubMed Central  Google Scholar 

Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220–9. https://doi.org/10.1001/archgenpsychiatry.2010.2.

Article  PubMed  Google Scholar 

Wang Z, Cheng Y, Li Y, Han J, Yuan Z, Li Q, et al. The relationship between obesity and depression is partly dependent on metabolic health status: A nationwide inpatient sample database study. Front Endocrinol (Lausanne). 2022;13:880230. https://doi.org/10.3389/fendo.2022.880230.

Article  PubMed  PubMed Central  Google Scholar 

Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, et al. Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol. 2019;48(3):834–48. https://doi.org/10.1093/ije/dyy223.

Article  PubMed  PubMed Central  Google Scholar 

Rindler GA, Gries A, Freidl W. Associations between overweight, obesity, and mental health: a retrospective study among European adults aged 50. Front Public Health. 2023;11:1206283. https://doi.org/10.3389/fpubh.2023.1206283.

Article  PubMed  PubMed Central  Google Scholar 

Drucker DJ. GLP-1-based therapies for diabetes, obesity and beyond. Nat Rev Drug Discov. 2025;24(8):631–50. https://doi.org/10.1038/s41573-025-01183-8.

Article  CAS  PubMed  Google Scholar 

Aoun L, Almardini S, Saliba F, Haddadin F, Mourad O, Jdaidani J, et al. GLP-1 receptor agonists: a novel pharmacotherapy for binge eating (binge eating disorder and bulimia nervosa)? A systematic review. J Clin Transl Endocrinol. 2024;35:100333. https://doi.org/10.1016/j.jcte.2024.100333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eddy KT, Dorer DJ, Franko DL, Tahilani K, Thompson-Brenner H, Herzog DB. Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V. Am J Psychiatry. 2008;165(2):245–50. https://doi.org/10.1176/appi.ajp.2007.07060951.

Article  PubMed  PubMed Central  Google Scholar 

Castellini G, Lo Sauro C, Mannucci E, Ravaldi C, Rotella CM, Faravelli C, et al. Diagnostic crossover and outcome predictors in eating disorders according to DSM-IV and DSM-V proposed criteria: a 6-year follow-up study. Psychosom Med. 2011;73(3):270–9. https://doi.org/10.1097/PSY.0b013e31820a1838.

Article  PubMed  Google Scholar 

Müller TD, Blüher M, Tschöp MH, DiMarchi RD. Anti-obesity drug discovery: advances and challenges. Nat Rev Drug Discov. 2022;21(3):201–23. https://doi.org/10.1038/s41573-021-00337-8.

Article  CAS  PubMed  Google Scholar 

Müller TD, Clemmensen C, Finan B, DiMarchi RD, Tschöp MH. Anti-obesity therapy: from rainbow pills to polyagonists. Pharmacol Rev. 2018;70(4):712–46. https://doi.org/10.1124/pr.117.014803.

Article  CAS  PubMed  Google Scholar 

Liu L, Li Z, Ye W, Peng P, Wang Y, Wan L, et al. Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta-analysis. EClinicalMedicine. 2025;79:103020. https://doi.org/10.1016/j.eclinm.2024.103020.

Article  PubMed  Google Scholar 

Kang JG, Park CY. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J. 2012;36(1):13–25. https://doi.org/10.4093/dmj.2012.36.1.13.

Article  PubMed  PubMed Central  Google Scholar 

Wong HJ, Sim B, Teo YH, Teo YN, Chan MY, Yeo LLL, et al. Efficacy of GLP-1 receptor agonists on weight loss, BMI, and waist circumference for patients with obesity or overweight: a systematic review, meta-analysis, and meta-regression of 47 randomized controlled trials. Diabetes Care. 2025;48(2):292–300. https://doi.org/10.2337/dc24-1678.

Article  CAS 

Comments (0)

No login
gif