Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet. 2016;388:86–97. https://doi.org/10.1016/S0140-6736(15)01121-6.

Article  PubMed  PubMed Central  Google Scholar 

Correll CU, Solmi M, Croatto G, et al. Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors. World Psychiatry Off J World Psychiatr Assoc. 2022;21:248–71. https://doi.org/10.1002/wps.20994.

Article  Google Scholar 

Laursen TM, Munk-Olsen T, Vestergaard M. Life expectancy and cardiovascular mortality in persons with schizophrenia. Curr Opin Psychiatry. 2012;25:83–8. https://doi.org/10.1097/YCO.0b013e32835035ca.

Article  PubMed  Google Scholar 

Vancampfort D, Stubbs B, Mitchell AJ, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry. 2015;14:339–47. https://doi.org/10.1002/wps.20252.

Article  PubMed  PubMed Central  Google Scholar 

Rajkumar AP, Horsdal HT, Wimberley T, et al. Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study. Am J Psychiatry. 2017;174:686–94. https://doi.org/10.1176/appi.ajp.2016.16040442.

Article  PubMed  Google Scholar 

Kowalchuk C, Castellani LN, Chintoh A, et al. Antipsychotics and glucose metabolism: how brain and body collide. Am J Physiol Endocrinol Metab. 2018;316:E1–15. https://doi.org/10.1152/ajpendo.00164.2018.

Article  CAS  PubMed  Google Scholar 

Castellani LN, Pereira S, Kowalchuk C, et al. Antipsychotics impair regulation of glucose metabolism by central glucose. Mol Psychiatry. 2022;27:4741–53. https://doi.org/10.1038/s41380-022-01798-y.

Article  CAS  PubMed  Google Scholar 

Smith ECC, Agarwal SM, Panganiban KJ, et al. Antipsychotic Drugs and Dysregulated Glucose Homeostasis. JAMA Psychiatry. 2025;82:977–91. https://doi.org/10.1001/jamapsychiatry.2025.2240.

Article  PubMed  PubMed Central  Google Scholar 

Freyberg Z, Aslanoglou D, Shah R, Ballon JS. Intrinsic and antipsychotic drug-induced metabolic dysfunction in schizophrenia. Front Neurosci. 2017;11:432. https://doi.org/10.3389/fnins.2017.00432.

Article  PubMed  PubMed Central  Google Scholar 

Perry BI, McIntosh G, Weich S, et al. The association between first-episode psychosis and abnormal glycaemic control: systematic review and meta-analysis. Lancet Psychiatry. 2016;3:1049–58. https://doi.org/10.1016/S2215-0366(16)30262-0.

Article  PubMed  Google Scholar 

Pillinger T, Beck K, Gobjila C, et al. Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2017;74:261–9. https://doi.org/10.1001/jamapsychiatry.2016.3803.

Article  PubMed  PubMed Central  Google Scholar 

Sullivan CR, O’Donovan SM, McCullumsmith RE, Ramsey A. Defects in bioenergetic coupling in schizophrenia. Biol Psychiatry. 2018;83:739–50. https://doi.org/10.1016/j.biopsych.2017.10.014.

Article  CAS  PubMed  Google Scholar 

Henkel ND, Wu X, O’Donovan SM, et al. Schizophrenia: a disorder of broken brain bioenergetics. Mol Psychiatry. 2022;27:2393–404. https://doi.org/10.1038/s41380-022-01494-x.

Article  CAS  PubMed  Google Scholar 

Kohen D. Diabetes mellitus and schizophrenia: Historical perspective. Br J Psychiatry. 2004. https://doi.org/10.1192/bjp.184.47.s64.

Article  Google Scholar 

Kasanin J. The blood sugar curve in mental disease: II. The schizophrenic (dementia praecox) groups. Arch Neurol Psychiatry. 1926;16:414–9. https://doi.org/10.1001/archneurpsyc.1926.02200280022002.

Article  Google Scholar 

Chouinard V-A, Henderson DC, Dalla Man C, et al. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2019;24:1513–22. https://doi.org/10.1038/s41380-018-0045-1.

Article  CAS  PubMed  Google Scholar 

Hackinger S, Prins B, Mamakou V, et al. Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. Transl Psychiatry. 2018;8:252. https://doi.org/10.1038/s41398-018-0304-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aymerich C, Pedruzo B, Pacho M, et al. Prolactin and morning cortisol concentrations in antipsychotic naïve first episode psychosis: A systematic review and meta-analysis. Psychoneuroendocrinology. 2023;150:106049. https://doi.org/10.1016/j.psyneuen.2023.106049.

Article  CAS  PubMed  Google Scholar 

Fernandes BS, Steiner J, Bernstein H-G, et al. C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications. Mol Psychiatry. 2016;21:554–64. https://doi.org/10.1038/mp.2015.87.

Article  CAS  PubMed  Google Scholar 

Frydecka D, Krzystek-Korpacka M, Lubeiro A, et al. Profiling inflammatory signatures of schizophrenia: A cross-sectional and meta-analysis study. Brain Behav Immun. 2018;71:28–36. https://doi.org/10.1016/j.bbi.2018.05.002.

Article  PubMed  Google Scholar 

González-Blanco L, Greenhalgh AMD, Garcia-Rizo C, et al. Prolactin concentrations in antipsychotic-naïve patients with schizophrenia and related disorders: A meta-analysis. Schizophr Res. 2016;174:156–60. https://doi.org/10.1016/j.schres.2016.03.018.

Article  PubMed  Google Scholar 

Hubbard DB, Miller BJ. Meta-analysis of blood cortisol levels in individuals with first-episode psychosis. Psychoneuroendocrinology. 2019;104:269–75. https://doi.org/10.1016/j.psyneuen.2019.03.014.

Article  CAS  PubMed  Google Scholar 

Miller BJ, Buckley P, Seabolt W, et al. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry. 2011;70:663–71. https://doi.org/10.1016/j.biopsych.2011.04.013.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park S, Miller BJ. Meta-analysis of cytokine and C-reactive protein levels in high-risk psychosis. Schizophr Res. 2020;226:5–12. https://doi.org/10.1016/j.schres.2019.03.012.

Article  PubMed  Google Scholar 

Sarnyai Z, Ben-Shachar D. Schizophrenia, a disease of impaired dynamic metabolic flexibility: a new mechanistic framework. Psychiatry Res. 2024;342:116220. https://doi.org/10.1016/j.psychres.2024.116220.

Article  CAS  PubMed  Google Scholar 

Hilker R, Helenius D, Fagerlund B, et al. Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register. Biol Psychiatry. 2018;83:492–8. https://doi.org/10.1016/j.biopsych.2017.08.017.

Article  PubMed  Google Scholar 

Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60:1187–92. https://doi.org/10.1001/archpsyc.60.12.1187.

Article  PubMed  Google Scholar 

Trubetskoy V, Pardiñas AF, Qi T, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604:502–8. https://doi.org/10.1038/s41586-022-04434-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benros ME, Nielsen PR, Nordentoft M, et al. Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. Am J Psychiatry. 2011;168:1303–10. https://doi.org/10.1176/appi.ajp.2011.11030516.

Article  PubMed  Google Scholar 

Howes OD, McCutcheon R, Owen MJ, Murray RM. The role of genes, stress, and dopamine in the development of schizophrenia. Biol Psychiatry. 2017;81:9–20. https://doi.org/10.1016/j.biopsych.2016.07.014.