Shimazu T, Fukuda A. Increased activities of glycogenolytic enzymes in liver after splanchnic-nerve stimulation. Science. 1965;150:1607–8.

Article  CAS  PubMed  Google Scholar 

Shimazu T, Fukuda A, Ban T. Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content. Nature. 1966;210:1178–9.

Article  CAS  PubMed  Google Scholar 

Shimazu T. Glycogen synthetase activity in liver: regulation by the autonomic nerves. Science. 1967;156:1256–7.

Article  CAS  PubMed  Google Scholar 

Uyama N, Geerts A, Reynaert H. Neural connections between the hypothalamus and the liver. Anat Rec Discov Mol Cell Evol Biol. 2004;280:808–20.

Article  Google Scholar 

Berthoud HR, Kressel M, Neuhuber WL. An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system. Anat Embryol (Berl). 1992;186:431–42.

Article  CAS  PubMed  Google Scholar 

Buijs RM, la Fleur SE, Wortel J, Van Heyningen C, Zuiddam L, Mettenleiter TC, et al. The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J Comp Neurol. 2003;464:36–48.

Article  PubMed  Google Scholar 

Goehler LE, Sternini C. Neuropeptide Y immunoreactivity in the mammalian liver: pattern of innervation and coexistence with tyrosine hydroxylase immunoreactivity. Cell Tissue Res. 1991;265:287–95.

Article  CAS  PubMed  Google Scholar 

Akiyoshi H, Gonda T, Terada T. A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers. Liver. 1998;18:352–9.

Article  CAS  PubMed  Google Scholar 

Mukherjee S, Dieguez C, Ferno J, Lopez M. Obesity wars: hypothalamic sevs a new hope. Trends Mol Med. 2023;29:622–34.

Article  CAS  PubMed  Google Scholar 

Lopez M, Nogueiras R, Tena-Sempere M, Dieguez C. Hypothalamic AMPK: a canonical regulator of whole-body energy balance. Nat Rev Endocrinol. 2016;12:421–32.

Article  CAS  PubMed  Google Scholar 

Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschop MH, Diano S, Bruning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021;3:299–308.

Article  PubMed  PubMed Central  Google Scholar 

Seoane-Collazo P, Ferno J, Gonzalez F, Dieguez C, Leis R, Nogueiras R, Lopez M. Hypothalamic-autonomic control of energy homeostasis. Endocrine. 2015;50:276–91.

Article  CAS  PubMed  Google Scholar 

Flak JN, Goforth PB, Dell’Orco J, Sabatini PV, Li C, Bozadjieva N, et al. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020;130:2943–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prida E, Alvarez-Delgado S, Perez-Lois R, Soto-Tielas M, Estany-Gestal A, Ferno J, Seoane LM, Quinones MO. Al-Massadi, Liver Brain Interactions: Focus on FGF21 a Systematic Review. Int J Mol Sci. 2022;23(21):13318.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med. 2010;16:1001–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortiga-Carvalho TM, Chiamolera MI, Pazos-Moura CC, Wondisford FE. Hypothalamus-Pituitary-Thyroid axis. Compr Physiol. 2016;6:1387–428.

Article  PubMed  Google Scholar 

Shimazu T. Neuronal regulation of hepatic glucose metabolism in mammals. Diabetes Metab Rev. 1987;3:185–206.

Article  CAS  PubMed  Google Scholar 

Shimazu T. Innervation of the liver and glucoregulation: roles of the hypothalamus and autonomic nerves. Nutrition. 1996;12:65–6.

CAS  PubMed  Google Scholar 

Huang Z, Liu L, Zhang J, Conde K, Phansalkar J, Li Z, et al. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022;8:eabn5345.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshimatsu H, Niijima A, Oomura Y, Yamabe K, Katafuchi T. Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. Brain Res. 1984;303:147–52.

Article  CAS  PubMed  Google Scholar 

Saito M, Minokoshi Y, Shimazu T. Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats. Brain Res. 1989;481:298–303.

Article  CAS  PubMed  Google Scholar 

Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Mol Cell Endocrinol. 2011;336:219–23.

Article  CAS  PubMed  Google Scholar 

Shimazu T. Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia. 1981;20:343–56.

Article  CAS  PubMed  Google Scholar 

Shimazu T. Reciprocal innervation of the liver: its significance in metabolic control. Adv Metab Disord. 1983;10:355–84.

Article  CAS  PubMed  Google Scholar 

Shimazu T, Ogasawara S. Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver. Am J Physiol. 1975;228:1787–93.

Article  CAS  PubMed  Google Scholar 

Liu L, Huang Z, Zhang J, Wang M, Yue T, Wang W, et al. Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice. Nat Commun. 2024;15:8632.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deussing JM, Chen A. The corticotropin-releasing factor family: physiology of the stress response. Physiol Rev. 2018;98:2225–86.

Article  CAS  PubMed  Google Scholar 

Steckler T, Holsboer F. Corticotropin-releasing hormone receptor subtypes and emotion. Biol Psychiatry. 1999;46:1480–508.

Article  CAS  PubMed  Google Scholar 

Savic B, Murphy D, Japundzic-Zigon N. The paraventricular nucleus of the hypothalamus in control of blood pressure and blood pressure variability. Front Physiol. 2022;13:858941.

Article  PubMed  PubMed Central  Google Scholar 

Ferguson AV, Latchford KJ, Samson WK. The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets. 2008;12:717–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalsbeek A, Bruinstroop E, Yi CX, Klieverik L, Liu J, Fliers E. Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis. Front Horm Res. 2014;42:1–28.

Article  PubMed