The IUPHAR/BPS Guide to PHARMACOLOGY (IMPDH2). 2025; Available from: https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2625
Kiang TK, Ensom MH. Anti-rejection drugs. In: Murphy JE, editor. Clinical pharmacokinetics. 6th ed. Bethesda: American Society of Health-System Pharmacists; 2017. p. 205–20.
Kiang TK, Ensom MH. Immunosuppressants. In: Beringer, editor. Basic clinical pharmacokinetics. Philadelphia: Wolters Kluwer; 2017. p. 320–58.
Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, et al. Personalized therapy for mycophenolate: consensus report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2021;43(2):150–200. https://doi.org/10.1097/FTD.0000000000000871.
Article PubMed CAS Google Scholar
Rong Y, Patel V, Kiang TKL. Recent lessons learned from population pharmacokinetic studies of mycophenolic acid: physiological, genomic, and drug interactions leading to the prediction of drug effects. Expert Opin Drug Metab Toxicol. 2022;17(12):1369–406. https://doi.org/10.1080/17425255.2021.2027906.
Staatz CE, Tett SE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin Pharmacokinet. 2007;46(1):13–58. https://doi.org/10.2165/00003088-200746010-00002.
Article PubMed CAS Google Scholar
Staatz CE, Tett SE. Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update. Arch Toxicol. 2014;88(7):1351–89. https://doi.org/10.1007/s00204-014-1247-1.
Article PubMed CAS Google Scholar
de Winter BC, van Gelder T, Sombogaard F, Shaw LM, van Hest RM, Mathot RA. Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients. J Pharmacokinet Pharmacodyn. 2009;36(6):541–64. https://doi.org/10.1007/s10928-009-9136-6.
Article PubMed PubMed Central CAS Google Scholar
Benjanuwattra J, Pruksakorn D, Koonrungsesomboon N. Mycophenolic acid and its pharmacokinetic drug-drug interactions in humans: review of the evidence and clinical implications. J Clin Pharmacol. 2020;60(3):295–311. https://doi.org/10.1002/jcph.1565.
Article PubMed CAS Google Scholar
Sherwin CM, Fukuda T, Brunner HI, Goebel J, Vinks AA. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011;50(1):1–24. https://doi.org/10.2165/11536640-000000000-00000.
Article PubMed PubMed Central CAS Google Scholar
Kiang TKL, Ensom MHH. Population pharmacokinetics of mycophenolic acid: an update. Clin Pharmacokinet. 2018;57(5):547–58. https://doi.org/10.1007/s40262-017-0593-6.
Article PubMed CAS Google Scholar
Kiang TKL, Ensom MHH. Exposure-toxicity relationships of mycophenolic acid in adult kidney transplant patients. Clin Pharmacokinet. 2019;58(12):1533–52. https://doi.org/10.1007/s40262-019-00802-z.
Atcheson BA, Taylor PJ, Mudge DW, Johnson DW, Hawley CM, Campbell SB, et al. Mycophenolic acid pharmacokinetics and related outcomes early after renal transplant. Br J Clin Pharmacol. 2005;59(3):271–80. https://doi.org/10.1111/j.1365-2125.2004.02235.x.
Article PubMed PubMed Central CAS Google Scholar
Kaplan B, Gruber SA, Nallamathou R, Katz SM, Shaw LM. Decreased protein binding of mycophenolic acid associated with leukopenia in a pancreas transplant recipient with renal failure. Transplantation. 1998;65(8):1127–9. https://doi.org/10.1097/00007890-199804270-00019.
Article PubMed CAS Google Scholar
Weber LT, Shipkova M, Armstrong VW, Wagner N, Schutz E, Mehls O, et al. The pharmacokinetic-pharmacodynamic relationship for total and free mycophenolic acid in pediatric renal transplant recipients: a report of the German study group on mycophenolate mofetil therapy. J Am Soc Nephrol. 2002;13(3):759–68. https://doi.org/10.1681/ASN.V133759.
Jacobson P, Rogosheske J, Barker JN, Green K, Ng J, Weisdorf D, et al. Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation. Clin Pharmacol Ther. 2005;78(5):486–500. https://doi.org/10.1016/j.clpt.2005.08.009.
Article PubMed CAS Google Scholar
Frymoyer A, Verotta D, Jacobson P, Long-Boyle J. Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors. Br J Clin Pharmacol. 2013;75(2):463–75. https://doi.org/10.1111/j.1365-2125.2012.04372.x.
Article PubMed PubMed Central CAS Google Scholar
Kiang TK, Ensom MH. Therapeutic drug monitoring of mycophenolate in adult solid organ transplant patients: an update. Expert Opin Drug Metab Toxicol. 2016;12(5):545–53. https://doi.org/10.1517/17425255.2016.1170806.
Article PubMed CAS Google Scholar
Metz DK, Holford N, Kausman JY, Walker A, Cranswick N, Staatz CE, et al. Optimizing mycophenolic acid exposure in kidney transplant recipients: time for target concentration intervention. Transplantation. 2019;103(10):2012–30. https://doi.org/10.1097/TP.0000000000002762.
Article PubMed PubMed Central CAS Google Scholar
Villeneuve C, Humeau A, Monchaud C, Labriffe M, Rerolle JP, Couzi L, et al. Better rejection-free survival at three years in kidney transplant recipients with model-informed precision dosing of mycophenolate mofetil. Clin Pharmacol Ther. 2024;116(2):351–62. https://doi.org/10.1002/cpt.3206.
Article PubMed CAS Google Scholar
Lentine KL, Smith JM, Lyden GR, Miller JM, Dolan TG, Bradbrook K, et al. OPTN/SRTR 2022 annual data report: kidney. Am J Transplant. 2024;24(2S1):S19–118. https://doi.org/10.1016/j.ajt.2024.01.012.
Raval AD, Kistler KD, Tang Y, Vincenti F. Burden of neutropenia and leukopenia among adult kidney transplant recipients: a systematic literature review of observational studies. Transpl Infect Dis. 2023;25(1):e14000. https://doi.org/10.1111/tid.14000.
van Gelder T, Hilbrands LB, Vanrenterghem Y, Weimar W, de Fijter JW, Squifflet JP, et al. A randomized double-blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation. Transplantation. 1999;68(2):261–6. https://doi.org/10.1097/00007890-199907270-00018.
van Gelder T. How cyclosporine reduces mycophenolic acid exposure by 40% while other calcineurin inhibitors do not. Kidney Int. 2021;100(6):1185–9. https://doi.org/10.1016/j.kint.2021.06.036.
Article PubMed CAS Google Scholar
van Hest RM, van Gelder T, Bouw R, Goggin T, Gordon R, Mamelok RD, et al. Time-dependent clearance of mycophenolic acid in renal transplant recipients. Br J Clin Pharmacol. 2007;63(6):741–52. https://doi.org/10.1111/j.1365-2125.2006.02841.x.
Article PubMed PubMed Central CAS Google Scholar
Rong Y, Mayo P, Ensom MHH, Kiang TKL. Population pharmacokinetics of mycophenolic acid co-administered with tacrolimus in corticosteroid-free adult kidney transplant patients. Clin Pharmacokinet. 2019;58(11):1483–95. https://doi.org/10.1007/s40262-019-00771-3.
Article PubMed CAS Google Scholar
Zafrani L, Truffaut L, Kreis H, Etienne D, Rafat C, Lechaton S, et al. Incidence, risk factors and clinical consequences of neutropenia following kidney transplantation: a retrospective study. Am J Transplant. 2009;9(8):1816–25. https://doi.org/10.1111/j.1600-6143.2009.02699.x.
Article PubMed CAS Google Scholar
McAdams-DeMarco MA, Law A, Tan J, Delp C, King EA, Orandi B, et al. Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients. Transplantation. 2015;99(4):805–10. https://doi.org/10.1097/TP.0000000000000444.
Article PubMed PubMed Central CAS Google Scholar
Ji SM, Xie KN, Chen JS, Wen JQ, Cheng DR, Li X, et al. Retrospective evaluation of the effect of mycophenolate mofetil dosage on survival of kidney grafts based on biopsy results. Transplant Proc. 2014;46(10):3383–9. https://doi.org/10.1016/j.transproceed.2014.09.107.
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