The inflammatory fingerprint reveals immune cell populations associated with disease activity in cardiac sarcoidosis

Drent M, Crouser ED, Grunewald J (2021) Challenges of sarcoidosis and its management. N Engl J Med 385(11):1018–1032. https://doi.org/10.1056/NEJMra2101555

Article  CAS  PubMed  Google Scholar 

Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP III (2022) Diagnosis and treatment of pulmonary sarcoidosis: a review. JAMA 327(9):856–867. https://doi.org/10.1001/jama.2022.1570

Article  CAS  PubMed  Google Scholar 

Birnie DH, Nery PB, Ha AC, Beanlands RSB (2016) Cardiac sarcoidosis. J Am Coll Cardiol 68(4):411–421. https://doi.org/10.1016/j.jacc.2016.03.605

Article  PubMed  Google Scholar 

Rossides M, Kullberg S, Grunewald J, Eklund A, Giuseppe DD, Askling J, Arkema EV (2022) Risk and predictors of heart failure in sarcoidosis in a population-based cohort study from Sweden. Heart 108(6):467–473. https://doi.org/10.1136/heartjnl-2021-319129

Article  PubMed  Google Scholar 

Rosenfeld LE, Chung MK, Harding CV, Spagnolo P, Grunewald J, Appelbaum J, Sauer WH, Culver DA, Joglar JA, Lin BA, Jellis CL, Dickfeld T-M, Kwon DH, Miller EJ, Cremer PC, Bogun F, Kron J, Bock A, Mehta D, Leis P, Siontis KC, Kaufman ES, Crawford T, Zimetbaum P, Zishiri ET, Singh JP, Ellenbogen KA, Chrispin J, Quadri S, Vincent LL, Patton KK, Kalbfleish S, Callahan TD, Murgatroyd F, Judson MA, Birnie D, Okada DR, Maulion C, Bhat P, Bellumkonda L, Blankstein R, Cheng RK, Farr MA, Estep JD (2021) Arrhythmias in cardiac sarcoidosis bench to bedside. Circ Arrhythm Electrophysiol 14 (2):e009203. https://doi.org/10.1161/CIRCEP.120.009203

Hulten E, Aslam S, Osborne M, Abbasi S, Bittencourt MS, Blankstein R (2016) Cardiac sarcoidosis-state of the art review. Cardiovasc Diagn Ther 6(1):50–63. https://doi.org/10.3978/j.issn.2223-3652.2015.12.13

Article  PubMed  PubMed Central  Google Scholar 

Ekström K, Lehtonen J, Nordenswan H-K, Mäyränpää MI, Räisänen-Sokolowski A, Kandolin R, Simonen P, Pietilä-Effati P, Alatalo A, Utriainen S, Rissanen TT, Haataja P, Kokkonen J, Vihinen T, Miettinen H, Kaikkonen K, Kerola T, Kupari M (2019) Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries. Eur Heart J 40(37):3121–3128. https://doi.org/10.1093/eurheartj/ehz428

Article  PubMed  Google Scholar 

Greulich S, Deluigi CC, Gloekler S, Wahl A, Zürn C, Kramer U, Nothnagel D, Bültel H, Schumm J, Grün S, Ong P, Wagner A, Schneider S, Nassenstein K, Gawaz M, Sechtem U, Bruder O, Mahrholdt H (2013) CMR imaging predicts death and other adverse events in suspected cardiac sarcoidosis. JACC: Cardiovasc Imaging 6(4):501–511. https://doi.org/10.1016/j.jcmg.2012.10.021

Baughman RP, Valeyre D, Korsten P, Mathioudakis AG, Wuyts WA, Wells A, Rottoli P, Nunes H, Lower EE, Judson MA, Israel-Biet D, Grutters JC, Drent M, Culver DA, Bonella F, Antoniou K, Martone F, Quadder B, Spitzer G, Nagavci B, Tonia T, Rigau D, Ouellette DR (2021) ERS clinical practice guidelines on treatment of sarcoidosis. Eur Respir J 58(6):2004079. https://doi.org/10.1183/13993003.04079-2020

Article  CAS  PubMed  Google Scholar 

Nabeta T, Kitai T, Naruse Y, Taniguchi T, Yoshioka K, Tanaka H, Okumura T, Sato S, Baba Y, Kida K, Tamaki Y, Matsumoto S, Matsue Y (2022) Risk stratification of patients with cardiac sarcoidosis: the ILLUMINATE-CS registry. Eur Heart J 43(36):3450–3459. https://doi.org/10.1093/eurheartj/ehac323

Article  PubMed  Google Scholar 

Greulich S, Gatidis S, Gräni C, Blankstein R, Glatthaar A, Mezger K, Müller KAL, Castor T, Mahrholdt H, Häntschel M, Hetzel J, Dittmann H, Nikolaou K, Gawaz M, la Fougère C, Krumm P (2022) Hybrid cardiac magnetic resonance/fluorodeoxyglucose positron emission tomography to differentiate active from chronic cardiac sarcoidosis. JACC: Cardiovasc Imaging 15(3):445–456. https://doi.org/10.1016/j.jcmg.2021.08.018

Greulich S, Mahrholdt H (2016) Prognosis of myocardial damage in sarcoidosis patients with preserved left ventricular ejection fraction. Circ: Cardiovasc Imaging 9(1):e004417. https://doi.org/10.1161/CIRCIMAGING.115.004417

Eurelings LEM, Miedema JR, Dalm V, van Daele PLA, van Hagen PM, van Laar JAM, Dik WA (2019) Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis. PLoS One 14(10):e0223897. https://doi.org/10.1371/journal.pone.0223897

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lebedeva M, Popova E, Ponomarev A, Sergei B (2011) Serum angiotensin converting enzyme (ACE) as additional clinical markers of activity of pulmonary and extra-pulmonary locations of sarcoidosis. Eur Respir J 38(Suppl 55):3734

Article  Google Scholar 

Kraaijvanger R, Janssen Bonás M, Vorselaars ADM, Veltkamp M (2020) Biomarkers in the diagnosis and prognosis of sarcoidosis: current use and future prospects. Front Immunol 11:1443. https://doi.org/10.3389/fimmu.2020.01443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Costabel U, Dai H (2021) The role of diverse immune cells in sarcoidosis. Front Immunol 12:788502. https://doi.org/10.3389/fimmu.2021.788502

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broos CE, van Nimwegen M, Hoogsteden HC, Hendriks RW, Kool M, van den Blink B (2013) Granuloma formation in pulmonary sarcoidosis. Front Immunol 4:437. https://doi.org/10.3389/fimmu.2013.00437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mueller KAL, Langnau C, Günter M, Pöschel S, Gekeler S, Petersen-Uribe Á, Kreisselmeier KP, Klingel K, Bösmüller H, Li B, Jaeger P, Castor T, Rath D, Gawaz MP, Autenrieth SE (2021) Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection. Cardiovasc Res 117(1):224–239. https://doi.org/10.1093/cvr/cvaa328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langnau C, Rohlfing A-K, Gekeler S, Günter M, Pöschel S, Petersen-Uribe Á, Jaeger P, Avdiu A, Harm T, Kreisselmeier K-P, Castor T, Bakchoul T, Rath D, Gawaz MP, Autenrieth SE, Mueller KAL (2021) Platelet activation and plasma levels of Furin are associated with prognosis of patients with coronary artery disease and COVID-19. Arterioscler Thromb Vasc Biol 41(6):2080–2096. https://doi.org/10.1161/ATVBAHA.120.315698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garman L, Pelikan RC, Rasmussen A, Lareau CA, Savoy KA, Deshmukh US, Bagavant H, Levin AM, Daouk S, Drake WP, Montgomery CG (2020) Single cell transcriptomics implicate novel monocyte and T cell immune dysregulation in sarcoidosis. Front Immunol 11. https://doi.org/10.3389/fimmu.2020.567342

Okamoto H, Mizuno K, Horio T (2003) Monocyte-derived multinucleated giant cells and sarcoidosis. J Dermatol Sci 31(2):119–128. https://doi.org/10.1016/S0923-1811(02)00148-2

Article  CAS  PubMed  Google Scholar 

Fang X, Zheng P, Tang J, Liu Y (2010) CD24: from A to Z. Cell Mol Immunol 7(2):100–103. https://doi.org/10.1038/cmi.2009.119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Busuttil A, Weigt SS, Keane MP, Xue YY, Palchevskiy V, Burdick MD, Huang C, Zisman DA, Fishbein M, III JPL, Strieter RM, Elashoff RM, Belperio JA (2009) CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis. Eur Respir J 34(3):676–686. https://doi.org/10.1183/09031936.00157508

Kudryavtsev I, Serebriakova M, Starshinova A, Zinchenko Y, Basantsova N, Malkova A, Soprun L, Churilov LP, Toubi E, Yablonskiy P, Shoenfeld Y (2020) Imbalance in B cell and T follicular helper cell subsets in pulmonary sarcoidosis. Sci Rep 10(1):1059. https://doi.org/10.1038/s41598-020-57741-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sweiss NJ, Salloum R, Ghandi S, Alegre M-L, Sawaqed R, Badaracco M, Pursell K, Pitrak D, Baughman RP, Moller DR, Garcia JGN, Niewold TB (2010) Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One 5(2):e9088. https://doi.org/10.1371/journal.pone.0009088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vakrakou AG, Kolilekas L, Lama N, Katsanos S, Stratakos G, Tsougos I, Manali E, Grigoriou E, Psarra K, Kilidireas C, Papiris S, Kelekis NL, Gialafos EJ (2022) Peripheral blood natural killer cells in sarcoidosis are associated with early cardiac involvement. Eur J Clin Invest 52(5):e13742. https://doi.org/10.1111/eci.13742

Article  CAS  PubMed  Google Scholar 

Sink J, Joyce C, Liebo MJ, Wilber DJ (2023) Long‐term outcomes of cardiac sarcoid: prognostic implications of isolated cardiac involvement and impact of diagnostic delays. J Am Heart Assoc 12(19):e028342. https://doi.org/10.1161/JAHA.122.028342

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lehtonen J, Uusitalo V, Pöyhönen P, Mäyränpää MI, Kupari M (2023) Cardiac sarcoidosis: phenotypes, diagnosis, treatment, and prognosis. Eur Heart J 44(17):1495–1510. https://doi.org/10.1093/eurheartj/ehad067

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Costabel U, Dai H (2021) The role of diverse immune cells in sarcoidosis. Front Immunol 12. https://doi.org/10.3389/fimmu.2021.788502

Korkmaz C, Demircioglu S (2020) The association of neutrophil/lymphocyte and platelet/lymphocyte ratios and hematological parameters with diagnosis, stages, extrapulmonary involvement, pulmonary hypertension, response to treatment, and prognosis in patients with sarcoidosis. Can Respir J 2020:1696450. https://doi.org/10.1155/2020/1696450

Article  PubMed  PubMed Central  Google Scholar 

Shen Y, Pang C, Wu Y, Li D, Wan C, Liao Z, Yang T, Chen L, Wen F (2016) Diagnostic performance of bronchoalveolar lavage fluid CD4/CD8 ratio for sarcoidosis: a meta-analysis. eBioMedicine 8:302–308. https://doi.org/10.1016/j.ebiom.2016.04.024

Ruiz SJ, Zhang Y, Mukhopadhyay S (2016) CD4/CD8 ratio in mediastinal lymph nodes involved by sarcoidosis: analysis of flow cy

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