Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI (2014) Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol 34:2363–2371
Article CAS PubMed Google Scholar
Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galiè N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV (2014) Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med 370:1402–1411
Article CAS PubMed Google Scholar
Fiumara K, Kucher N, Fanikos J, Goldhaber SZ (2006) Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism. Am J Cardiol 97:127–129
Shahidi P, Mentzel L, Blazek S, Sulimov D, Thiele H, Fengler K (2024) From pulmonary embolism to chronic thromboembolic pulmonary hypertension: a pathophysiological approach. RCM 25:402
Kawakami T, Ogawa A, Miyaji K, Mizoguchi H, Shimokawahara H, Naito T, Oka T, Yunoki K, Munemasa M, Matsubara H (2016) Novel angiographic classification of each vascular lesion in chronic thromboembolic pulmonary hypertension based on selective angiogram and results of balloon pulmonary angioplasty. Circ Cardiovasc Interv 9:e003318
Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing G-J, Harjola V-P, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ní Áinle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL, ESC Scientific Document Group, Galié N, Gibbs JSR, Aboyans V, Ageno W, Agewall S, Almeida AG, Andreotti F, Barbato E, Bauersachs J, Baumbach A, Beygui F, Carlsen J, De Carlo M, Delcroix M, Subias PE, Fitzsimons D, Gaine S, Goldhaber SZ, Gopalan D, Habib G, Halvorsen S, Jenkins D, Katus HA, Kjellström B, Klok FA, Konradi A, Koskinas KC, Kotecha D, Lang I, Lewis BS, Linhart A, Lip GYH, Løchen ML, Mathioudakis AG, Mindham R, Moledina S, Naeije R, Nielsen JC, Olschewski H, Opitz I, Petersen SE, Prescott E, Rakisheva A, Reis A, Ristić AD, Roche N, Rodrigues R, Selton-Suty C, Souza R, Swift AJ, Touyz RM, Ulrich S, Wilkins MR, Wort SJ (2020) 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 41:543–603
Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, Rådegran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S, ESC/ERS Scientific Document Group, Schwerzmann M, Dinh-Xuan AT, Bush A, Abdelhamid M, Aboyans V, Arbustini E, Asteggiano R, Barberà JA, Beghetti M, Čelutkienė J, Cikes M, Condliffe R, De Man F, Falk V, Fauchier L, Gaine S, Galié N, Gin-Sing W, Granton J, Grünig E, Hassoun PM, Hellemons M, Jaarsma T, Kjellström B, Klok FA, Konradi A, Koskinas KC, Kotecha D, Lang I, Lewis BS, Linhart A, Lip GYH, Løchen ML, Mathioudakis AG, Mindham R, Moledina S, Naeije R, Nielsen JC, Olschewski H, Opitz I, Petersen SE, Prescott E, Rakisheva A, Reis A, Ristić AD, Roche N, Rodrigues R, Selton-Suty C, Souza R, Swift AJ, Touyz RM, Ulrich S, Wilkins MR, Wort SJ (2022) 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 2022(43):3618–731
Papamatheakis DG, Poch DS, Fernandes TM, Kerr KM, Kim NH, Fedullo PF (2020) Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol 76:2155–2169
Toma C, Bunte MC, Cho KH, Jaber WA, Chambers J, Stegman B, Gondi S, Leung DA, Savin M, Khandhar S, Kado H, Koenig G, Weinberg M, Beasley RE, Roberts J, Angel W, Sarosi MG, Qaqi O, Veerina K, Brown MA, Pollak JS (2022) Percutaneous mechanical thrombectomy in a real-world pulmonary embolism population: interim results of the FLASH registry. Catheter Cardiovasc Interv 99:1345–1355
PubMed PubMed Central Google Scholar
Toma C, Jaber WA, Weinberg MD, Bunte MC, Khandhar S, Stegman B, Gondi S, Chambers J, Amin R, Leung DA, Kado H, Brown MA, Sarosi MG, Bhat AP, Castle J, Savin M, Siskin G, Rosenberg M, Fanola C, Horowitz JM, Pollak JS (2023) Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism. EuroIntervention 18:1201–1212
Article PubMed PubMed Central Google Scholar
Kucher N, Boekstegers P, Müller OJ, Kupatt C, Beyer-Westendorf J, Heitzer T, Tebbe U, Horstkotte J, Müller R, Blessing E, Greif M, Lange P, Hoffmann R-T, Werth S, Barmeyer A, Härtel D, Grünwald H, Empen K, Baumgartner I (2014) Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism. Circulation 129:479–486
Turetz M, Sideris A, Friedman O, Triphathi N, Horowitz J (2018) Epidemiology, pathophysiology, and natural history of pulmonary embolism. Semin Intervent Radiol 35:92–98
Article PubMed PubMed Central Google Scholar
Keller K, Schmidt FP, Farmakis IT, Barco S, Fengler K, Knorr M, Gori T, Münzel T, Lurz P, Hobohm L (2025) Time trends of catheter-directed treatment in acute pulmonary embolism in Germany. Res Pract Thromb Haemost 9:102651
Giannakoulas G, Farmakis IT, Hobohm L, Verbrugge FH, Tedford RJ, Sanz J (2025) Acute right ventricular failure: pathophysiology, aetiology, assessment, and management. Eur Heart J. https://doi.org/10.1093/eurheartj/ehaf215
Piazza G, Hohlfelder B, Jaff MR, Ouriel K, Engelhardt TC, Sterling KM, Jones NJ, Gurley JC, Bhatheja R, Kennedy RJ, Goswami N, Natarajan K, Rundback J, Sadiq IR, Liu SK, Bhalla N, Raja ML, Weinstock BS, Cynamon J, Elmasri FF, Garcia MJ, Kumar M, Ayerdi J, Soukas P, Kuo W, Liu P-Y, Goldhaber SZ (2015) A prospective, single-arm, multicenter trial of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute massive and submassive pulmonary embolism. JACC Cardiovasc Interv 8:1382–1392
Tu T, Toma C, Tapson VF, Adams C, Jaber WA, Silver M, Khandhar S, Amin R, Weinberg M, Engelhardt T, Hunter M, Holmes D, Hoots G, Hamdalla H, Maholic RL, Lilly SM, Ouriel K, Rosenfield K (2019) A prospective, single-arm, multicenter trial of catheter-directed mechanical thrombectomy for intermediate-risk acute pulmonary embolism. JACC Cardiovasc Interv 12:859–869
Simonneau G, Dorfmüller P, Guignabert C, Mercier O, Humbert M (2022) Chronic thromboembolic pulmonary hypertension: the magic of pathophysiology. Ann Cardiothorac Surg 11:106–119
Article PubMed PubMed Central Google Scholar
Simeone B, Maggio E, Schirone L, Rocco E, Sarto G, Spadafora L, Bernardi M, Ambrosio LD, Forte M, Vecchio D, Valenti V, Sciarretta S, Vizza CD (2024) Chronic thromboembolic pulmonary hypertension: the diagnostic assessment. Front Cardiovasc Med 11:1439402
Article CAS PubMed PubMed Central Google Scholar
Valerio L, Mavromanoli AC, Barco S, Abele C, Becker D, Bruch L, Ewert R, Faehling M, Fistera D, Gerhardt F, Ghofrani HA, Grgic A, Grünig E, Halank M, Held M, Hobohm L, Hoeper MM, Klok FA, Lankeit M, Leuchte HH, Martin N, Mayer E, Meyer FJ, Neurohr C, Opitz C, Schmidt KH, Seyfarth HJ, Wachter R, Wilkens H, Wild PS, Konstantinides SV, Rosenkranz S, FOCUS Investigators, Abele C, Barco S, Becker D, Fischer B, Hobohm L, Käberich A, Keller K, Klok FA, Martin N, Mavromanoli AC, Konstantinides SV, Lankeit M, Otto S, Quitzau K, Rost K, Schmidt K-H, Schöneberger D, Valerio L, Wild PS, Bruch L, Geistert S, Schüler K, Ewert R, Pohl C, Pieper J, Faehling M, Blaich B, Landmesser A, Rosenkranz S, Gerhardt F, Rudolph J, Gün S, Ghofrani H-A, George U, Grünig E, Egenlauf B, Salkić A, Heier E-M, Halank M, Tausche K, Rink T, Jäkel D, Held M, Schröder B, Hoeper MM, Freise J, Tayler S, Leuchte HH, Horn A, Meyer FJ, Emge-Rossa D, Thabaret K, Neurohr C, Barton J, Opitz C, Bressem I, Seyfarth H-J, Berger P, Hennig A, Wachter R, Hellenkamp K, Sentler C, Schulte M, Wilkens H, Trudzinski F, Holtz I (2022) Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study. Eur Heart J 43:3387–98
Article PubMed PubMed Central Google Scholar
Klok FA, Couturaud F, Delcroix M, Humbert M (2020) Diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Eur Respir J 55:2000189
Gall H, Hoeper MM, Richter MJ, Cacheris W, Hinzmann B, Mayer E (2017) An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan. Eur Respir Rev 26:160121
Article PubMed PubMed Central Google Scholar
Simonneau G, Hoeper MM (2017) Evaluation of the incidence of rare diseases: difficulties and uncertainties, the example of chronic thromboembolic pulmonary hypertension. Eur Respir J 49:1602522
Feinstein JA, Goldhaber SZ, Lock JE, Ferndandes SM, Landzberg MJ (2001) Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Circulation 103:10–13
Article CAS PubMed Google Scholar
Lang IM, Andreassen AK, Andersen A, Bouvaist H, Coghlan G, Escribano-Subias P, Jansa P, Kopec G, Kurzyna M, Matsubara H, Meyer BC, Palazzini M, Post MC, Pruszczyk P, Räber L, Roik M, Rosenkranz S, Wiedenroth CB, Redlin-Werle C, Brenot P (2023) Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a clinical consensus statement of the ESC working group on pulmonary circulation and right ventricular function. Eur Heart J 44:2659–2671
Article CAS PubMed PubMed Central Google Scholar
Yang JZ, Poch DS, Ang L, Mahmud E, Kim NH (2023) Balloon pulmonary angioplasty in the current era of CTEPH treatment: how did we get here? Pulm Circ 13:e12312
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