Lukas Stolz received speaker honoraria from Edwards Lifesciences. Karl-Patrik Kresoja reports travel expenses from Edwards Lifesciences. Jennifer von Stein received Lecture honoraria from Edwards Lifesciences. Wolfgang Rottbauer received speaker honoraria Edwards and Abbott. Paolo Denti served as Consultant for InnovHeart, Picardia, HVR, and Approxima and received Speaker Honoraria from Abbott and Edwards. Tienush Rassaf received speaker honoraria and consulting fees from Astra Zeneca, Bayer, Pfizer, and Daiichi Sankyo. Manuel Barreiro-Perez received speaker fees from Abbott Vascular, Edwards Lifesciences, and Venus Medtech. Marianna Adamo received consulting fees in the last 3 years from Abbott Structural Heart and Edwards LifeSciences. Stefan Toggweiler has received honoraria from Medtronic, Boston Scientific, Biosensors, Edwards Lifesciences, Microport, P + F, Hi-D Imaging, Abbott Vascular, Medira, Shockwave, Teleflex, atHeart Medical, Cardiac Dimensions, Polares Medical, Amarin, Sanofi, AstraZeneca, ReCor Medical, Daiichi Sankyo, Bayer, and Armira; has received institutional research grants from Medtronic, Edwards Lifesciences, Abbott Vascular, Boston Scientific, Fumedica, Novartis, Boehringer Ingelheim, and Polares Medical; and holds equity in Hi-D Imaging. Marco Metra received consulting fees in the last 3 years from Abbott Structural Heart, Astra-Zeneca, Bayer, Boheringer Ingelheim, Edwards LifeSciences, and Roche Diagnostics. Tobias Geisler received speaker honoraria/research grants from Astra Zeneca, Bayer, Bristol Myers Squibb/Pfizer, Ferrer/Chiesi, Medtronic, and Edwards Lifesciences. None of them was related to this study. Rodrigo Estévez-Loureiro received speaker fees from Abbott Vascular, Edwards Lifesciences, Boston Scientific, and Venus Medtech. Francesco Maisano received Grant and/or Research Institutional Support from Abbott, Medtronic, Edwards Lifesciences, Biotronik, Boston Scientific Corporation, NVT, Terumo, Venus and Consulting fees, Honoraria personal and Institutional from Abbott, Medtronic, Edwards Lifesciences, Xeltis, Cardiovalve, Occlufit, Simulands, Mtex, Venus, Squadra, and Valgen Royalty Income/IP Rights Edwards Lifesciences and is shareholder (including share options) of Magenta, Transseptalsolutions, and 4Tech. Mirjam Kessler received speaker honoraria Edwards and Abbott. Daniel Kalbacher has received personal fees from Abbott Medical, Edwards Lifesciences, Pi-Cardia Ltd, and Medtronic Inc. Volker Rudolph received Research grants from Abbott Medical, Boston Scientific, and Edwards Lifesciences. Christos Iliadis received consultant fees and travel expenses from Abbott Medical and Edwards LifeSciences. Alessandro Sticchi served on the advisory board for Edwards Lifesciences. Philipp Lurz received institutional grants from Edwards Lifesciences and honoraria from Innoventrics. Jörg Hausleiter reports research grant support and speaker honoraria from Edwards Lifesciences. All other authors have no relevant conflicts of interest to declare. Giuseppe Tarantini received speaker fee for Abbott Vascular and Edwards Lifesciences. Amir Mahabadi received peaker fees and/or advisory boards: Amgen, Berlin Chemie, Daiichi Sankyo, Edwards, Novartis, and Sanofi. Research funding: Daiichi Sankyo, Edwards, all outside the submitted work. Mark Lachmann has received funding from the Technical University of Munich (Clinician Scientist Grant), from the Else Kröner-Fresenius Foundation (Clinician Scientist Grant), from the German Center for Cardiovascular Research (DZHK; Postdoc Start-up Grant on Advancing Digital Aspects), and from the German Heart Foundation (“Machine learning in severe mitral regurgitation”). Thomas Nestelberger has received research support from the Swiss National Science Foundation (P400PM_191037/1), the Prof. Dr. Max Cloëtta Foundation, the Margarete und Walter Lichtenstein-Stiftung (3MS1038), the Freiwillige Akademische Gesellschaft Basel, the Stiftung kardiovaskuläre Forschung Basel, the University of Basel, the University Hospital Basel, as well as speaker/consulting honoraria or research support from Edwards Lifesciences, Pronova Medical, Meril, Boston Scientific, Medtronic, Abbott, Beckman Coulter, Bayer, Ortho Clinical Diagnostics, and Orion Pharma, outside the submitted work. Martin Swaans served as proctor/lecturer for Abbott Vascular, Bioventrix inc, Boston Scientific, Cardiac Dimensions, Edwards Lifesciences, GE Healthcare, Medtronic, P&F, Philips Healthcare, and Siemens.