Hardcastle SA (2022) Pregnancy and lactation associated osteoporosis. Calcif Tissue Int 110:531–545

Article  CAS  PubMed  Google Scholar 

Cohen A (2024) Bone metabolism, bone mass, and bone structure during pregnancy and lactation: normal physiology and pregnancy and lactation-associated osteoporosis. Endocrinol Metab Clin North Am 53:453–470

Article  PubMed  Google Scholar 

Kondapalli AV, Kamanda-Kosseh M, Williams JM et al (2023) Clinical characteristics of pregnancy and lactation associated osteoporosis: an online survey study. Osteoporos Int 34:1477–1489. https://doi.org/10.1007/s00198-023-06793-9

Article  CAS  PubMed  Google Scholar 

Grassi G, Zampogna M, Atlasova A et al (2025) Identifying risk factors for pregnancy and lactation-associated osteoporosis: insights from an Italian survey in PLAO patients and controls. Front Endocrinol (Lausanne). https://doi.org/10.3389/fendo.2025.1612188

Article  PubMed  PubMed Central  Google Scholar 

El-Najjar D, Metzger C, Allen MR et al (2024) Women with pregnancy and lactation associated osteoporosis (PLO) have low bone turnover at multiple postpartum timepoints: a transiliac bone biopsy study. In: ASBMR Annual Meeting, Toronto, Canada

Cohen A, Kamanda-Kosseh M, Dempster DW et al (2019) Women with pregnancy and lactation–associated osteoporosis (PLO) have low bone remodeling rates at the tissue level. J Bone Miner Res 34:1552–1561. https://doi.org/10.1002/jbmr.3750

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lynch LK, Shea P, Vena N et al (2026) Genetic contributors to osteoporosis in pregnancy and lactation associated osteoporosis (PLO). Bone 204:117744. https://doi.org/10.1016/j.bone.2025.117744

Article  CAS  PubMed  Google Scholar 

Butscheidt S, Tsourdi E, Rolvien T et al (2021) Relevant genetic variants are common in women with pregnancy and lactation-associated osteoporosis (PLO) and predispose to more severe clinical manifestations. Bone. https://doi.org/10.1016/j.bone.2021.115911

Article  PubMed  Google Scholar 

Scioscia MF, Zanchetta MB (2023) Recent insights into pregnancy and lactation-associated osteoporosis (PLO). Int J Womens Health 15:1227–1238

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kovacs CS (2016) Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery. Physiol Rev 96:449–547. https://doi.org/10.1152/physrev.00027.2015

Article  CAS  PubMed  Google Scholar 

Sowers M, Corton G, Shapiro B et al (1993) Changes in bone density with lactation. JAMA 269:3130–3135

Article  CAS  PubMed  Google Scholar 

Karlsson C, Obrant KJ, Karlsson M (2001) Pregnancy and lactation confer reversible bone loss in humans. Osteoporos Int 12:828–834

Article  CAS  PubMed  Google Scholar 

Kolthoff N, Eiken P, Nielsen SP (1998) Bone mineral changes during pregnancy and lactation: a longitudinal cohort study. Clin Sci 94:405-412

Brembeck P, Lorentzon M, Ohlsson C et al (2015) Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum. J Clin Endocrinol Metab 100:535–543. https://doi.org/10.1210/jc.2014-2825

Article  CAS  PubMed  Google Scholar 

Bjørnerem Å, Ghasem-Zadeh A, Wang X et al (2017) Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. J Bone Miner Res 32:681–687. https://doi.org/10.1002/jbmr.3090

Article  CAS  PubMed  Google Scholar 

de Bakker CMJ, Li Y, Zhao H et al (2018) Structural adaptations in the rat tibia bone induced by pregnancy and lactation confer protective effects against future estrogen deficiency. J Bone Miner Res 33:2165–2176. https://doi.org/10.1002/jbmr.3559

Article  PubMed  PubMed Central  Google Scholar 

Wiklund PK, Xu L, Wang Q et al (2012) Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int 23:1939–1945. https://doi.org/10.1007/s00198-011-1790-z

Article  CAS  PubMed  Google Scholar 

Specker B, Binkley T (2005) High parity is associated with increased bone size and strength. Osteoporos Int 16:1969–1974. https://doi.org/10.1007/s00198-005-1978-1

Article  PubMed  Google Scholar 

Cooke-Hubley S, Gao Z, Mugford G et al (2019) Parity and lactation are not associated with incident fragility fractures or radiographic vertebral fractures over 16 years of follow-up: Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos. https://doi.org/10.1007/s11657-019-0601-6

Article  PubMed  Google Scholar 

Crandall CJ, Liu J, Cauley J et al (2017) Associations of parity, breastfeeding, and fractures in the Women’s Health Observational Study. Obstet Gynecol 130:171–180. https://doi.org/10.1097/AOG.0000000000002096

Article  PubMed  PubMed Central  Google Scholar 

Hong N, Kim JE, Lee SJ et al (2018) Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis. Clin Endocrinol (Oxf) 88:652–658. https://doi.org/10.1111/cen.13557

Article  CAS  PubMed  Google Scholar 

Phillips AJ, Ostlere SJ, Smith R (2000) Pregnancy-associated osteoporosis: does the skeleton recover? Osteoporos Int 11:449–454

Article  CAS  PubMed  Google Scholar 

Kyvernitakis I, Reuter TC, Hellmeyer L et al (2018) Subsequent fracture risk of women with pregnancy and lactation-associated osteoporosis after a median of 6 years of follow-up. Osteoporosis International 29:135–142. https://doi.org/10.1007/s00198-017-4239-1

Article  CAS  PubMed  Google Scholar 

Kyvernitakis I, Reuter TC, Hellmeyer L et al (2023) Correction to: subsequent fracture risk of women with pregnancy and lactation-associated osteoporosis after a median of 6 years of follow-up. Osteoporosis International 34:2143–2144

Article  PubMed  Google Scholar 

Hardcastle SA, Yahya F, Bhalla AK (2019) Pregnancy-associated osteoporosis: a UK case series and literature review. Osteoporos Int 30:939–948

Article  CAS  PubMed  Google Scholar 

Lampropoulou-Adamidou K, Trovas G, Triantafyllopoulos IK et al (2021) Teriparatide treatment in patients with pregnancy- and lactation-associated osteoporosis. Calcif Tissue Int 109:554–562. https://doi.org/10.1007/s00223-021-00871-y

Article  CAS  PubMed  Google Scholar 

Laroche M, Talibart M, Cormier C et al (2017) Pregnancy-related fractures: a retrospective study of a French cohort of 52 patients and review of the literature. Osteoporosis International 28:3135–3142. https://doi.org/10.1007/s00198-017-4165-2

Article  CAS  PubMed  Google Scholar 

O’Sullivan SM, Grey AB, Singh R, Reid IR (2006) Bisphosphonates in pregnancy and lactation-associated osteoporosis. Osteoporos Int 17:1008–1012. https://doi.org/10.1007/s00198-006-0112-3

Article  CAS  PubMed  Google Scholar 

Stumpf UC, Kurth AA, Windolf J, Fassbender WJ (2007) Pregnancy-associated osteoporosis: an underestimated and underdiagnosed severe disease. A review of two cases in short- and long-term follow-up. Adv Med Sci 52:94–97

CAS  PubMed  Google Scholar 

Kaneuchi Y, Iwabuchi M, Hakozaki M et al (2023) Pregnancy and lactation-associated osteoporosis successfully treated with romosozumab: a case report. Medicina (Lithuania) 59. https://doi.org/10.3390/medicina59010019

Anagnostis P, Lampropoulou-Adamidou K, Bosdou JK et al (2024) Comparative effectiveness of therapeutic interventions in pregnancy and lactation-associated osteoporosis: a systematic review and meta-analysis. J Clin Endocrinol Metab 109:879–901

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali DS, Khan AA, Brandi ML (2024) Effective strategies for pregnancy and lactation-associated osteoporosis: teriparatide use in focus. Endocrine 86:459–469

Article  CAS  PubMed