Dessi A, Di Maria C, Pintus R, Fanos V, Bosco A. Lipidomics and metabolomics in infant atopic dermatitis: what’s the correlation with early nutrition? Curr Pediatr Rev. 2024;20(4):510–24. https://doi.org/10.2174/1573396320666230411093122.

Article  CAS  PubMed  Google Scholar 

Davari DR, Nieman EL, McShane DB, Morrell DS. Current perspectives on the management of infantile atopic dermatitis. J Asthma Allergy. 2020;13:563–73. https://doi.org/10.2147/JAA.S246175.

Article  CAS  PubMed  Google Scholar 

Nemeth V, Syed HA, Evans J, Eczema. StatPearls. Treasure Island (FL)2025.

Fuxench ZC, Mitra N, Del Pozo D, Hoffstad O, Shin DB, Langan SM, et al. In utero or early-in-life exposure to antibiotics and the risk of childhood atopic dermatitis, a population-based cohort study. Br J Dermatol. 2024;191(1):58–64. https://doi.org/10.1093/bjd/ljad428.

Article  CAS  PubMed  Google Scholar 

Tsuchida A, Itazawa T, Matsumura K, Yokomichi H, Yamagata Z, Adachi Y, et al. Season of birth and atopic dermatitis in early infancy: results from the Japan environment and children’s study. BMC Pediatr. 2023;23(1):78. https://doi.org/10.1186/s12887-023-03878-6.

Article  PubMed  Google Scholar 

Yokomichi H, Mochizuki M, Tsuchida A, Kojima R, Horiuchi S, Ooka T, et al. Association of the incidence of atopic dermatitis until 3 years old with birth month and with sunshine duration and humidity in the first 6 months of life: Japan environment and children’s study. BMJ Open. 2021;11(7):e047226. https://doi.org/10.1136/bmjopen-2020-047226.

Article  PubMed  Google Scholar 

Vassilopoulou E, Rallis D, Milani GP, Agostoni C, Feketea G, Lithoxopoulou M, et al. Nurturing infants to prevent atopic dermatitis and food allergies: a longitudinal study. Nutrients. 2023. https://doi.org/10.3390/nu16010021.

Article  PubMed  Google Scholar 

Lee E, Rhie S, Kim JH, Ha EK, Kim MS, Lee WS, et al. National trends and disparities in complementary food diversity among infants: a 12-year cross-sectional birth cohort study. Nutrients. 2025. https://doi.org/10.3390/nu17040636.

Article  PubMed  Google Scholar 

Jiang S, Cai M, Li D, Chen X, Chen X, Huang Q, et al. Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis. Gut. 2024;74(1):45–57. https://doi.org/10.1136/gutjnl-2024-332407.

Article  CAS  PubMed  Google Scholar 

Chaudhary PP, Myles IA, Zeldin J, Dabdoub S, Deopujari V, Baveja R, et al. Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis. Allergy. 2023;78(10):2724–31. https://doi.org/10.1111/all.15806.

Article  CAS  PubMed  Google Scholar 

Fonfara M, Hartmann J, Stolzl D, Sander N, Harder I, Rodriguez E, et al. Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis. J Eur Acad Dermatol Venereol. 2024;38(9):1769–75. https://doi.org/10.1111/jdv.19932.

Article  CAS  PubMed  Google Scholar 

Puisto R, Gomez-Gallego C, Collado MC, Turta O, Isolauri E, Rautava S. The role of infant gut microbiota modulation by perinatal maternal probiotic intervention in atopic eczema risk reduction. Neonatology. 2025;122(1):84–94. https://doi.org/10.1159/000540075.

Article  CAS  PubMed  Google Scholar 

Sung M, Choi Y, Park H, Huh CS. Gut microbiome characteristics in mothers and infants according to the presence of atopic dermatitis. Biomed Res Int. 2022;2022:8145462. https://doi.org/10.1155/2022/8145462.

Article  CAS  PubMed  Google Scholar 

Swaney MH, Steidl OR, Tackett A, Fye S, Lee KE, Ong IM, et al. Farm exposure is associated with human breast milk immune profile and microbiome. bioRxiv. 2024. https://doi.org/10.1101/2024.10.14.618271.

Article  PubMed  Google Scholar 

Belugina I, Yagovdik N, Belugina O, Belugin S. The impact of meteorological factors on the incidence of infantile atopic dermatitis. Int J Dermatol. 2024;63(12):e405–14. https://doi.org/10.1111/ijd.17404.

Article  PubMed  Google Scholar 

Rinnov MR, Halling AS, Gerner T, Ravn NH, Knudgaard MH, Trautner S, et al. Skin biomarkers predict development of atopic dermatitis in infancy. Allergy. 2023;78(3):791–802. https://doi.org/10.1111/all.15518.

Article  CAS  PubMed  Google Scholar 

Renert-Yuval Y, Del Duca E, Pavel AB, Fang M, Lefferdink R, Wu J, et al. The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults. J Allergy Clin Immunol. 2021;148(1):148–63. https://doi.org/10.1016/j.jaci.2021.01.001.

Article  CAS  PubMed  Google Scholar 

Hong Z, Jing R, Hui L, Kang X, Chunmei Z, Yang W, et al. A cohort study of intrapartum group B streptococcus prophylaxis on atopic dermatitis in 2-year-old children. BMC Pediatr. 2022;22(1):693. https://doi.org/10.1186/s12887-022-03758-5.

Article  CAS  PubMed  Google Scholar 

Tai SK, Lin YH, Lin CH, Lin MC. Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study. Eur J Med Res. 2024;29(1):189. https://doi.org/10.1186/s40001-024-01793-9.

Article  PubMed  Google Scholar 

Zhang Z, Wang R, Li M, Lu M. Current insights and trends in atopic dermatitis and microbiota interactions: a systematic review and bibliometric analysis. Front Microbiol. 2025;16:1613315. https://doi.org/10.3389/fmicb.2025.1613315.

Article  PubMed  Google Scholar 

Mogoş GFR, Manciulea Profir M, Enache RM, Pavelescu LA, Popescu Roşu OA, Cretoiu SM, et al. Intestinal microbiota in early life: latest findings regarding the role of probiotics as a treatment approach for dysbiosis. Nutrients. 2025. https://doi.org/10.3390/nu17132071.

Article  PubMed  Google Scholar 

Schoch JJ, Monir RL, Satcher KG, Harris J, Triplett E, Neu J. The infantile cutaneous microbiome: a review. Pediatr Dermatol. 2019;36(5):574–80. https://doi.org/10.1111/pde.13870.

Article  PubMed  Google Scholar 

Tsuge M, Ikeda M, Matsumoto N, Yorifuji T, Tsukahara H. Current insights into atopic march. Children. 2021. https://doi.org/10.3390/children8111067.

Article  PubMed  Google Scholar 

Stokholm J, Thorsen J, Schoos AM, Rasmussen MA, Brandt S, Sorensen SJ, et al. Infantile colic is associated with development of later constipation and atopic disorders. Allergy. 2024;79(12):3360–72. https://doi.org/10.1111/all.16274.

Article  CAS  PubMed  Google Scholar 

Wheeler KE, Chu DK, Schneider L. Updated guidelines for atopic dermatitis-AAAAI/ACAAI joint task force. JAMA Pediatr. 2024;178(10):961–2. https://doi.org/10.1001/jamapediatrics.2024.1395.

Article  PubMed  Google Scholar 

Vassilopoulou E, Comotti A, Douladiris N, Konstantinou G, Zuberbier T, Alberti I, et al. A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: an EAACI task force report. Allergy. 2024;79(7):1708–24. https://doi.org/10.1111/all.16160.

Article  CAS  PubMed  Google Scholar 

Venter C. Immunonutrition: diet diversity, gut microbiome and prevention of allergic diseases. Allergy Asthma Immunol Res. 2023;15(5):545–61. https://doi.org/10.4168/aair.2023.15.5.545.

Article  PubMed  Google Scholar 

van Brakel L, Thijs C, Mensink RP, Lutjohann D, Plat J. Non-cholesterol sterols in breast milk and risk of allergic outcomes in the first two years of life. Nutrients. 2022. https://doi.org/10.3390/nu14040766.

Article  PubMed  Google Scholar 

Li T, Zheng Q, Xu J, Li Y, Zhang M, Zhang B, et al. Comparison of 11 formulas and breastfeeding for atopic dermatitis and growth in pediatric cow’s milk protein allergy: a systematic review and network meta-analysis of 23 randomized controlled trials. J Evid Based Med. 2025;18(2):e70026. https://doi.org/10.1111/jebm.70026.

Article  PubMed  Google Scholar 

Venter C, Brown KR, Maslin K, Palmer DJ. Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring. Pediatr Allergy Immunol. 2017;28(2):135–43. https://doi.org/10.1111/pai.12682.

Article  PubMed  Google Scholar 

Zeng J, Wu W, Tang N, Chen Y, Jing J, Cai L. Maternal dietary protein patterns during pregnanc