Gittler JK, Krueger JG, Guttman-Yassky E. Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis. J Allergy Clin Immunol. 2013;131(2):300–13.
Article CAS PubMed Google Scholar
Suárez-Fariñas M, Tintle SJ, Shemer A, Chiricozzi A, Nograles K, Cardinale I, et al. Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954–64.e1-4.
Article PubMed PubMed Central Google Scholar
Riethmuller C, McAleer MA, Koppes SA, Abdayem R, Franz J, Haftek M, et al. Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis. J Allergy Clin Immunol. 2015;136(6):1573–e802.
Article CAS PubMed PubMed Central Google Scholar
Brooks SG, Mahmoud RH, Lin RR, Fluhr JW, Yosipovitch G. The Skin Acid Mantle: An Update on Skin pH. J Invest Dermatol. 2025;145(3):509–21.
Article CAS PubMed Google Scholar
Peng G, Abudouwanli A, Sun Q, Tan Y, Zhao W, Yang M et al. Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis. The Journal of Dermatology.n/a(n/a).
Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, et al. Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor. Cell Host Microbe. 2021;29(8):1235–e488.
Article CAS PubMed PubMed Central Google Scholar
Hülpüsch C, Rohayem R, Reiger M, Traidl-Hoffmann C. Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification. J Allergy Clin Immunol. 2024;154(1):31–41.
Brauweiler AM, Goleva E, Leung DYM. Staphylococcus aureus Lipoteichoic Acid Damages the Skin Barrier through an IL-1-Mediated Pathway. J Invest Dermatol. 2019;139(8):1753–e614.
Article CAS PubMed PubMed Central Google Scholar
Pytelková J, Orsághová K, Beňová M, Horn M, Schabussova I, Mareš M. Allergenic mites excrete cathepsins B and C as active cysteine proteases distinct from group 1 allergens. Int J Biol Macromol. 2025;331(Pt 2):148383.
Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 1983;80(1 Suppl):s44–9.
Elias PM, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Allergy Asthma Rep. 2009;9(4):265–72.
Article CAS PubMed Google Scholar
Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441–6.
Article CAS PubMed Google Scholar
Leung DYM, Calatroni A, Zaramela LS, LeBeau PK, Dyjack N, Brar K, et al. The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype. Sci Transl Med. 2019;11:480.
Fukuda K, Ito Y, Furuichi Y, Matsui T, Horikawa H, Miyano T, et al. Three stepwise pH progressions in stratum corneum for homeostatic maintenance of the skin. Nat Commun. 2024;15(1):4062.
Article CAS PubMed PubMed Central Google Scholar
Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, et al. NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. 2002;277(49):47399–406.
Article CAS PubMed Google Scholar
Fluhr JW, Behne MJ, Brown BE, Moskowitz DG, Selden C, Mao-Qiang M, et al. Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. J Invest Dermatol. 2004;122(2):320–9.
Article CAS PubMed Google Scholar
Choi EH, Kang H. Importance of Stratum Corneum Acidification to Restore Skin Barrier Function in Eczematous Diseases. Ann Dermatol. 2024;36(1):1–8.
Article CAS PubMed PubMed Central Google Scholar
Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129(8):1892–908.
Article CAS PubMed Google Scholar
Kim E, Kim S, Nam GW, Lee H, Moon S, Chang I. The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation. Int J Cosmet Sci. 2009;31(4):263–9.
Article CAS PubMed Google Scholar
Li R, Rodrigues M, Li L, Winget J, Wang Y, Wang C, et al. Association Between Skin Acid Mantle, Natural Moisturizing Factors, and Antibacterial Activity Against S. aureus in the Stratum Corneum. Clin Cosmet Investig Dermatol. 2023;16:1595–606.
Article CAS PubMed PubMed Central Google Scholar
Gruber R, Elias PM, Crumrine D, Lin TK, Brandner JM, Hachem JP, et al. Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol. 2011;178(5):2252–63.
Article PubMed PubMed Central Google Scholar
Bandier J, Johansen JD, Petersen LJ, Carlsen BC. Skin pH, atopic dermatitis, and filaggrin mutations. Dermatitis. 2014;25(3):127–9.
Article CAS PubMed Google Scholar
Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, et al. Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model. J Invest Dermatol. 2016;136(1):127–35.
Article CAS PubMed Google Scholar
Wilson SR, Thé L, Batia LM, Beattie K, Katibah GE, McClain SP, et al. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell. 2013;155(2):285–95.
Article CAS PubMed PubMed Central Google Scholar
Zheng Y, Hunt RL, Villaruz AE, Fisher EL, Liu R, Liu Q, et al. Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides. Cell Host Microbe. 2022;30(3):301–e139.
Article CAS PubMed PubMed Central Google Scholar
Nakatsuji T, Hata TR, Tong Y, Cheng JY, Shafiq F, Butcher AM, et al. Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial. Nat Med. 2021;27(4):700–9.
Article CAS PubMed PubMed Central Google Scholar
Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, et al. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans. J Invest Dermatol. 2017;137(10):2110–9.
Article CAS PubMed Google Scholar
Bissonnette R, Stein Gold L, Kircik L, Simpson EL, Eichenfield LF, Browning J, et al. Skin clearance, duration of treatment-free interval, and safety of tapinarof cream 1% once daily: Results from ADORING 3, a 48-week phase 3 open-label extension trial in adults and children down to 2 years of age with atopic dermatitis. J Am Acad Dermatol. 2025;93(3):707–14.
Article CAS PubMed Google Scholar
van Hout NE, Nevot G, Jansen PAM, Mannan AA, Zeeuwen P, Hijnen DJ et al. From prebiotics to engineered microbes: microbe-inspired therapies for atopic dermatitis. Br J Dermatol. 2025.
Nilsson EJ, Henning CG, Magnusson J. Topical corticosteroids and Staphylococcus aureus in atopic dermatitis. J Am Acad Dermatol. 1992;27(1):29–34.
Article CAS PubMed Google Scholar
Stalder JF, Fleury M, Sourisse M, Rostin M, Pheline F, Litoux P. Local steroid therapy and bacterial skin flora in atopic dermatitis. Br J Dermatol. 1994;131(4):536–40.
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