Stevens WW, Schleimer RP, Kern RC. Chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol Pract. 2016;4:565–72. https://doi.org/10.1016/j.jaip.2016.04.012.

Article  PubMed  PubMed Central  Google Scholar 

Samitas K, Carter A, Kariyawasam HH, Xanthou G. Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited. Allergy. 2018;73:993–1002. https://doi.org/10.1111/all.13373.

Article  CAS  PubMed  Google Scholar 

Hughes KM, Price D, Torriero AAJ, Symonds MRE, Suphioglu C. Impact of fungal spores on asthma prevalence and hospitalization. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23084313.

Article  PubMed  PubMed Central  Google Scholar 

Feng CH, Miller MD, Simon RA. The united allergic airway: connections between allergic rhinitis, asthma, andchronic sinusitis. Am J Rhinol Allergy. 2012;26:187–90. https://doi.org/10.2500/ajra.2012.26.3762.

Article  PubMed  PubMed Central  Google Scholar 

Li D, Guo S, Cui S, Yu J, Liu Z, Wang K, et al. Development and validation of a clinical risk prediction model for chronic sinusitis with nasal polyps: a retrospective analysis. Eur Arch Otorhinolaryngol. 2025;282:4109–22. https://doi.org/10.1007/s00405-025-09557-9.

Article  PubMed  PubMed Central  Google Scholar 

Hellings PW, Fokkens WJ, Orlandi R, Adriaensen GF, Alobid I, Baroody FM, et al. The EUFOREA pocket guide for chronic rhinosinusitis*. Rhinology. 2023;61:85–9. https://doi.org/10.4193/Rhin22.344.

Article  CAS  PubMed  Google Scholar 

Eriksen PRG, Jakobsen KK, Aanæs K, Backer V, von Buchwald C. The potential role of biological treatment of chronic rhinosinusitis with nasal polyps: a nationwide cohort study*. Rhinology. 2021. https://doi.org/10.4193/Rhin20.480.

Article  PubMed  Google Scholar 

Hellings PW, Verhoeven E, Fokkens WJ. State-of-the-art overview on biological treatment for CRSwNP. Rhinology. 2021;59:151–63. https://doi.org/10.4193/Rhin20.570.

Article  CAS  PubMed  Google Scholar 

Fokkens WJ, Backer V, Lund VJ, Barnes PJ, Bernal-Sprekelsen M, Bjermer L, et al. Pocket guide: biologics in upper and lower airways in adults. Rhinology. 2025;63:242–4. https://doi.org/10.4193/Rhin24.510.

Article  CAS  PubMed  Google Scholar 

De Prins L, Raap U, Mueller T, Schmid-Grendelmeier P, Haase CH, Backer V, et al. White paper on European patient needs and suggestions on chronic type 2 inflammation of airways and skin by EUFOREA. Front Allergy. 2022;3:1–12. https://doi.org/10.3389/falgy.2022.889221.

Article  Google Scholar 

Viskens A, Backer V. EPOS/EUFOREA update on indication and evaluation of biologics in chronic rhinosinusitis with nasal polyps 2023. Rhinology. 2023. https://doi.org/10.4193/rhin22.489.

Article  PubMed  Google Scholar 

Hopkins C, Mullol J, Khan AH, Lee SE, Wagenmann M, Hellings P, et al. Impact of Dupilumab on sinonasal symptoms and outcomes in severe chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg. 2024;170:1173–82. https://doi.org/10.1002/ohn.627.

Article  PubMed  Google Scholar 

Whitcroft KL, Altundag A, Balungwe P, Douglas R, Enecilla MLB, Fjaeldstad AW, et al. Position paper on olfactory dysfunction. Rhinology. 2023;61:1–108. https://doi.org/10.4193/Rhin22.483.

Article  CAS  PubMed  Google Scholar 

Soler ZM, Nash S, Lane AP, Patel ZM, Lee SE, Fokkens WJ, et al. Reduced sense of smell in patients with severe chronic rhinosinusitis and its implications for diagnosis and management: a narrative review. Adv Ther. 2024;41:4384–95. https://doi.org/10.1007/s12325-024-02984-w.

Article  PubMed  PubMed Central  Google Scholar 

Alobid I, Calvo-Henríquez C, Viveros-Díez P, López-Chacón M, Rojas-Lechuga M, Langdon C, et al. Validation of Visual Analogue Scale for loss of smell as a quick test in chronic rhinosinusitis with nasal polyps. J Investig Allergy Clin Immunol. 2023;34:377–84. https://doi.org/10.18176/jiaci.0937.

Peters AT, Tan BK, Stevens WW. Consultation for chronic rhinosinusitis with nasal polyps and asthma: clinical presentation, diagnostic workup, and treatment options. The Journal of Allergy and Clinical Immunology: In Practice. 2024;12:2898–905. https://doi.org/10.1016/j.jaip.2024.07.019.

Article  PubMed  PubMed Central  Google Scholar 

Fokkens WJ, De Corso E, Backer V, Bernal-Sprekelsen M, Bjermer L, von Buchwald C, et al. EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP. Rhinology. 2024;62:287–98. https://doi.org/10.4193/Rhin23.415.

Article  CAS  PubMed  Google Scholar 

Bech M, Jakobsen KK, Andersen ISB, Pedersen CK, Grønlund MW, von Buchwald C. Which is superior, the University of Pennsylvania Smell Identification Test or the threshold, discrimination and identification test for testing human olfaction? A systematic review. Acta Otolaryngol. 2025;145:241–4. https://doi.org/10.1080/00016489.2025.2458170.

Article  Google Scholar 

Hellings PW, Alobid I, Anselmo-Lima WT, Bernal-Sprekelsen M, Bjermer L, Caulley L, et al. EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care. Allergy. 2024;79:1123–33. https://doi.org/10.1111/all.15982.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:1–9. https://doi.org/10.1136/bmj.n71.

Article  Google Scholar 

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6. https://doi.org/10.1136/bmj.39489.470347.AD.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:1–8. https://doi.org/10.1136/bmj.l4898.

Article  Google Scholar 

Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet. 2019;394:1638–50. https://doi.org/10.1016/S0140-6736(19)31881-1.

Article  CAS  PubMed  Google Scholar 

Gevaert P, Omachi TA, Corren J, Mullol J, Han J, Lee SE, et al. Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials. J Allergy Clin Immunol. 2020;146:595–605. https://doi.org/10.1016/j.jaci.2020.05.032.

Article  CAS  PubMed  Google Scholar 

Han JK, Bachert C, Fokkens W, Desrosiers M, Wagenmann M, Lee SE, et al. Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021;9:1141–53. https://doi.org/10.1016/S2213-2600(21)00097-7.

Article  CAS  PubMed  Google Scholar 

Zheng M, Wu D, Piao Y, Tang J, Quan F, Guan B, et al. Efficacy and safety of GR1802 in uncontrolled chronic rhinosinusitis with nasal polyps: placebo-controlled phase 2 trial. J Allergy Clin Immunol. 2025;155:1575–83. https://doi.org/10.1016/j.jaci.2025.01.034.

Article  CAS  PubMed  Google Scholar 

Tversky J, Lane AP, Azar A. Benralizumab effect on severe chronic rhinosinusitis with nasal polyps (CRSwNP): a randomized double-blind placebo-controlled trial. Clin Exp Allergy. 2021;51:836–44. https://doi.org/10.1111/cea.13852.

Article  CAS  PubMed  Google Scholar 

Lipworth BJ, Han JK, Desrosiers M, Hopkins C, Lee SE, Mullol J, et al. Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps. N Engl J Med. 2025;392:1178–88. https://doi.org/10.1056/NEJMoa2414482.

Article  CAS  PubMed  Google Scholar 

Bachert C, Mannen L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA. 2016;315:469–79. https://doi.org/10.1001/jama.2015.19330.

Article  CAS  PubMed  Google Scholar 

La Mantia I, Grigaliute E, Ragusa M, Cocuzza S, Radulesco T, Saibene AM, et al. Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study. Eur Arch Otorhinolaryngol. 2024;281:219–26. https://doi.org/10.1007/s00405-023-08184-6.