Mortimer K, Reddel HK, Pitrez PM et al. Asthma management in low and middle income countries: case for change. Eur Respir J; 60. Epub ahead of print 15 Sept 2022. https://doi.org/10.1183/13993003.03179-2021

Wang J, Zhou Y, Zhang H, et al. Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduct Target Ther. 2023;8:138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Li L, Cai B, et al. Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma. Respir Res. 2024;25:76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reddel HK, Bacharier LB, Bateman ED, et al. Global Initiative for asthma strategy 2021: executive summary and rationale for key changes. Am J Respir Crit Care Med. 2022;205:17–35.

Article  PubMed  PubMed Central  Google Scholar 

Sharma S, Gerber AN, Kraft M et al. Asthma Pathogenesis: Phenotypes, Therapies, and Gaps: Summary of the Aspen Lung Conference 2023. Am J Respir Cell Mol Biol. 2024; 71: 154–168.

Sahnoon L, Bajbouj K, Mahboub B, et al. Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma. Clin Rev Allergy Immunol. 2025;68:44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodney D, Britt J, Ruwanpathirana A, Ford ML et al. Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma. Int J Mol Sci; 24. Epub ahead of print 21 June 2023. https://doi.org/10.3390/ijms241310451

Pelaia C, Heffler E, Crimi C et al. Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets. Front Pharmacol; 13. Epub ahead of print 8 March 2022. https://doi.org/10.3389/fphar.2022.851940

Komlósi ZI, van de Veen W, Kovács N, et al. Cellular and molecular mechanisms of allergic asthma. Mol Aspects Med. 2022;85:100995.

Article  PubMed  Google Scholar 

Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184:1469–85.

Article  CAS  PubMed  Google Scholar 

Pham DD, Kim T-B. Epithelial-derived cytokines in the pathogenesis of severe asthma. Front Allergy; 6. Epub ahead of print 15 Oct 2025. https://doi.org/10.3389/falgy.2025.1681147

Rodriguez-Rodriguez N, Gogoi M, McKenzie ANJ. Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma. Annu Rev Immunol. 2021;39:167–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aegerter H, Lambrecht BN, Jakubzick CV. Biology of lung macrophages in health and disease. Immunity. 2022;55:1564–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meloun A, Bachus H, Lewis C et al. Atypical pericapillary Ly6G+Nur77+ macrophages initiate type-2 immune responses to allergens in the mouse lung. Nat Commun. Epub ahead of print 22 Jan 2026. https://doi.org/10.1038/s41467-026-68652-5

Guilliams M, Svedberg FR. Does tissue imprinting restrict macrophage plasticity? Nat Immunol. 2021;22:118–27.

Article  CAS  PubMed  Google Scholar 

Misharin AV, Morales-Nebreda L, Reyfman PA, et al. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017;214:2387–404.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakarov S, Lim HY, Tan L, et al. Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science. 2019;363:eaau0964.

Article  CAS  PubMed  Google Scholar 

Niessen NM, Gibson PG, Baines KJ, et al. Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment. Allergy. 2021;76:2090–101.

Article  CAS  PubMed  Google Scholar 

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44:450–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vivier E, Artis D, Colonna M, et al. Innate lymphoid cells: 10 years on. Cell. 2018;174:1054–66.

Article  CAS  PubMed  Google Scholar 

Malewicz M. Studies on the role of Nur77 nuclear orphan receptors and Rel/NF-[kappa] B transcription factors in T cell receptor-mediated apoptosis. Forschungszentrum Karlsruhe; 2003.

Hussell T, Bell TJ. Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol. 2014;14:81–93.

Article  CAS  PubMed  Google Scholar 

Gibbings SL, Thomas SM, Atif SM, et al. Three unique interstitial macrophages in the murine lung at steady state. Am J Respir Cell Mol Biol. 2017;57:66–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11:723–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girodet P-O, Nguyen D, Mancini JD, et al. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016;55:467–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lehner C, Spitzer G, Gehwolf R, et al. Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1. Dis Model Mech. 2019;12:dmm041384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Satoh T, Nakagawa K, Sugihara F, et al. Identification of an atypical monocyte and committed progenitor involved in fibrosis. Nature. 2017;541:96–101.

Article  CAS  PubMed  Google Scholar 

Fukuda Y, Akimoto K, Homma T, et al. Virus-induced asthma exacerbations: SIRT1 targeted approach. J Clin Med. 2020;9:2623.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vanneste D, Bai Q, Hasan S, et al. MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. Nat Immunol. 2023;24:827–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruscitti C, Abinet J, Maréchal P, et al. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Sci Immunol. 2024;9:eado1227.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lith SC, Evers TMJ, Freire BM, et al. Nuclear receptor Nur77 regulates immunomechanics of macrophages. Eur J Cell Biol. 2024;103:151419.

Article  CAS  PubMed  Google Scholar 

Garabuczi É, Tarban N, Fige É et al. Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation. Front Immunol; 14. Epub ahead of print 3 March 2023. https://doi.org/10.3389/fimmu.2023.1139204

Hanna RN, Shaked I, Hubbeling HG, et al. NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis. Circ Res. 2012;110:416–27.

Article  CAS  PubMed  Google Scholar 

Kabata H, Moro K, Koyasu S. The group 2 innate lymphoid cell (ILC 2) regulatory network and its underlying mechanisms. Immunol Rev. 2018;286:37–52.

Article  CAS  PubMed  Google Scholar 

Saradna A, Do DC, Kumar S, et al. Macrophage polarization and allergic asthma. Transl Res. 2018;191:1–14.

Article  CAS  PubMed  Google Scholar 

Plantinga L, Bremner JD, Miller AH, et al. Association between posttraumatic stress disorder and inflammation: a twin study. Brain Behav Immun. 2013;30:125–32.

Article  CAS  PubMed  PubMed Central